The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Microbiome therapeutics — Advances and challenges
Open accessAbstract
The microbial community that lives on and in the human body exerts a major impact on human health, from metabolism to immunity. In order to leverage the close associations between microbes and their host, development of therapeutics targeting the microbiota has surged in recent years. Here, we discuss current additive and subtractive strategies to manipulate the microbiota, focusing on bacteria engineered to produce therapeutic payloads, consortia of natural organisms and selective antimicrobials. Further, we present challenges faced by the community in the development of microbiome therapeutics, including designing microbial therapies that are adapted for specific geographies in the body, stable colonization with microbial therapies, discovery of clinically relevant biosensors, robustness of engineered synthetic gene circuits and addressing safety and biocontainment concerns. Moving forward, collaboration between basic and applied researchers and clinicians to address these challenges will poise the field to herald an age of next-generation, cellular therapies that draw on novel findings in basic research to inform directed augmentation of the human microbiota.
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Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
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Microbiota and metabolic diseases
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Synthetic biology 2020–2030: six commercially-available products that are changing our world
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Metadata
- Authors
- Mimee, M., Citorik, R. J., & Lu, T. K.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 105
- Issue
- Pt A
- Pages
- 44-54
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2346027246
- Cited by
- 317
- References
- 178
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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