The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Peptides for nucleic acid delivery
Open accessAbstract
Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells. To overcome this, many different drug delivery systems have been devised. Among others, short delivery peptides, called cell-penetrating peptides (CPPs), have been demonstrated to allow for efficient delivery of nucleic acids and their ON analogs, in both cell culture and animal models. In this review, we provide brief overview of the latest advances in nucleic acid delivery with CPPs, covering the two main vectorization strategies, covalent conjugation and nanoparticle formation-based approach. In conclusion, CPP-based drug delivery systems have the capacity to overcome the hurdle of delivery and thus have the potential to facilitate the clinical translation of nucleic acid-based therapeutics.
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Cites
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Antisense oligonucleotides: the next frontier for treatment of neurological disorders
Rinaldi, C., & Wood, M. J. A. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.148 · Cited by 788
Self-citationMulticomponent peptide assemblies
Raymond, D. M., & Nilsson, B. L. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00115d · Cited by 346
Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery
Ho, W., Gao, M., Li, F., Li, Z., Zhang, X., & Xu, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001812 · Cited by 261
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Gene Delivery Technologies with Applications in Microalgal Genetic Engineering
Gutiérrez, S., & Lauersen, K. J. (2021) · Biology · doi:10.3390/biology10040265 · Cited by 68
Metadata
- Authors
- Lehto, T., Ezzat, K., Wood, M. J. A., & EL Andaloussi, S.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 106
- Issue
- Pt A
- Pages
- 172-182
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2467743933
- Cited by
- 220
- References
- 6
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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