The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Macrophage-based therapeutic strategies in regenerative medicine
Open accessAbstract
Abstract Mounting evidence suggests that therapeutic cell and drug delivery strategies designed to actively harness the regenerative potential of the inflammatory response have great potential in regenerative medicine. In particular, macrophages have emerged as a primary target because of their critical roles in regulating multiple phases of tissue repair through their unique ability to rapidly shift phenotypes. Herein, we review macrophage‐based therapies, focusing on the translational potential for cell delivery of ex vivo‐activated macrophages and delivery of molecules and biomaterials to modulate accumulation and phenotype of endogenous macrophages. We also review current obstacles to progress in translating basic findings to therapeutic applications, including the need for improved understanding of context‐dependent macrophage functions and the myriad factors that regulate macrophage phenotype; potential species‐specific differences (e.g. humans versus mice); quality control issues; and the lack of standardized procedures and nomenclature for characterizing macrophages. Looking forward, the inherent plasticity of macrophages represents a daunting challenge for harnessing these cells in regenerative medicine therapies but also great opportunity for improving patient outcomes in a variety of pathological conditions. Graphical abstract Figure. No Caption available.
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Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · cited 1×
“It is now generally accepted that a wide variety of stimuli can influence macrophage phenotype, resulting in practically infinite numbers of phenotypes and a spectrum of diverse behaviors, particularly in vivo [21,22].”
BackgroundThe chemokine system in diverse forms of macrophage activation and polarization
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Foreign body reaction to biomaterials
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Macrophages in Tissue Repair, Regeneration, and Fibrosis
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Inflammation in Wound Repair: Molecular and Cellular Mechanisms
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Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107
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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
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Cited by
Therapeutic strategies for enhancing angiogenesis in wound healing
Veith, A. P., Henderson, K., Spencer, A., Sligar, A. D., & Baker, A. B. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.010 · Cited by 1,021
Falanga, V., Isseroff, R. R., Soulika, A. M., Romanelli, M., Margolis, D., Kapp, S., Granick, M., & Harding, K. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00377-3 · Cited by 1,020
Amani, H., Arzaghi, H., Bayandori, M., Dezfuli, A. S., Pazoki‐Toroudi, H., Shafiee, A., & Moradi, L. (2019) · Advanced Materials Interfaces · doi:10.1002/admi.201900572 · Cited by 436
Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis
Witherel, C. E., Abebayehu, D., Barker, T. H., & Spiller, K. L. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801451 · Cited by 374
Self-citationGong, Y., Wang, P., Cao, R., Wu, J., Ji, H., Wang, M., Hu, C., Huang, P., & Wang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c04556 · Cited by 291
Metadata
- Authors
- Spiller, K. L., & Koh, T. J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 122
- Pages
- 74-83
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2614841288
- Cited by
- 307
- References
- 39
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- green
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