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The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.

Recent advancements in liposome technology

Filipczak, Nina, Pan, Jiayi, Yalamarty, Satya Siva Kishan, Torchilin, Vladimir P.·2020·Advanced Drug Delivery Reviews

Abstract

The liposomes have continued to be well-recognized as an important nano-sized drug delivery system with attractive properties, such a characteristic bilayer structure assembling the cellular membrane, easy-to-prepare and high bio-compatibility. Extensive effort has been devoted to the development of liposome-based drug delivery systems during the past few decades. Many drug candidates have been encapsulated in liposomes and investigated for reduced toxicity and extended duration of therapeutic effect. The liposomal encapsulation of hydrophilic and hydrophobic small molecule therapeutics as well as other large molecule biologics have been established among different academic and industrial research groups. To date, there has been an increasing number of FDA-approved liposomal-based therapeutics together with more and more undergoing clinical trials, which involve a wide range of applications in anticancer, antibacterial, and antiviral therapies. In order to meet the continuing demand for new drugs in clinics, more recent advancements have been investigated for optimizing liposomal-based drug delivery system with more reproducible preparation technique and a broadened application to novel modalities, including nucleic acid therapies, CRISPR/Cas9 therapies and immunotherapies. This review focuses on the recent liposome' preparation techniques, the excipients of liposomal formulations used in various novel studies and the routes of administration used to deliver liposomes to targeted areas of disease. It aims to update the research in liposomal delivery and highlights future nanotechnological approaches.

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Metadata

Authors
Filipczak, N., Pan, J., Yalamarty, S. S. K., & Torchilin, V. P.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2020
Volume
156
Pages
4-22
ISSN
0169-409X (ISSN-L)
OpenAlex
W3037359618
Cited by
592
References
175
FWCI
4.02
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Recent advancements in liposome technology. https://app.cochat.ai/papers/10.1016/j.addr.2020.06.022
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Filipczak, N., Pan, J., Yalamarty, S. S. K., & Torchilin, V. P. (2020). Recent advancements in liposome technology. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2020.06.022

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