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Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment
Abstract
Wound healing is characterized by complex, orchestrated, spatiotemporal dynamic processes. Recent findings demonstrated suitable local microenvironments were necessities for wound healing. Wound microenvironments include various biological, biochemical and physical factors, which are produced and regulated by endogenous biomediators, exogenous drugs, and external environment. Successful drug delivery to wound is complicated, and need to overcome the destroyed blood supply, persistent inflammation and enzymes, spatiotemporal requirements of special supplements, and easy deactivation of drugs. Triggered by various factors from wound microenvironment itself or external elements, stimuli-responsive biomaterials have tremendous advantages of precise drug delivery and release. Here, we discuss recent advances of stimuli-responsive biomaterials to regulate local microenvironments during wound healing, emphasizing on the design and application of different biomaterials which respond to wound biological/biochemical microenvironments (ROS, pH, enzymes, glucose and glutathione), physical microenvironments (mechanical force, temperature, light, ultrasound, magnetic and electric field), and the combination modes. Moreover, several novel promising drug carriers (microbiota, metal-organic frameworks and microneedles) are also discussed.
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“However, PLCL itself is relatively simple and can only provide a mechanical barrier for the wound healing process, so it is necessary to further improve the overall performance of the wound dressing by loading other materials or biological factors [141, 142].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [142]
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Metadata
- Authors
- Li, H., Li, B., Lv, D., Li, W., Lu, Y., & Luo, G.
- Affiliations
- Army Medical University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
- Corresponding author
- Lu, Yifei
- Luo, Gaoxing
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2023-05
- Volume
- 196
- Pages
- 114778
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W4324335398
- Cited by
- 142
- References
- 227
- Citations by year
- 2026: 35 · 2025: 53 · 2024: 39 · 2023: 15
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82002036, SZYZTR02)
- National Key Research and Development Program of China (2021YFA1101100)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- wound healing, stimuli-responsive biomaterials, drug delivery, wound microenvironment, reactive oxygen species, pH-responsive materials, enzyme-responsive materials, mechanical stimuli, temperature-responsive materials, photoresponsive materials, magnetic field-responsive materials, metal-organic frameworks, microneedles
- MeSH terms
- Metal-Organic Frameworks, Biocompatible Materials, Drug Carriers, Humans, Wound Healing, Drug Delivery Systems
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