Cited by 142Wound Healing and TreatmentsHydrogels: synthesis, properties, applicationsElectrospun Nanofibers in Biomedical Applications

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Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment

Li, Haisheng, Li, Buying, Lv, Dalun, Li, Wenhong, Lu, Yifei, Luo, Gaoxing·2023·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2023.114778

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Abstract

Wound healing is characterized by complex, orchestrated, spatiotemporal dynamic processes. Recent findings demonstrated suitable local microenvironments were necessities for wound healing. Wound microenvironments include various biological, biochemical and physical factors, which are produced and regulated by endogenous biomediators, exogenous drugs, and external environment. Successful drug delivery to wound is complicated, and need to overcome the destroyed blood supply, persistent inflammation and enzymes, spatiotemporal requirements of special supplements, and easy deactivation of drugs. Triggered by various factors from wound microenvironment itself or external elements, stimuli-responsive biomaterials have tremendous advantages of precise drug delivery and release. Here, we discuss recent advances of stimuli-responsive biomaterials to regulate local microenvironments during wound healing, emphasizing on the design and application of different biomaterials which respond to wound biological/biochemical microenvironments (ROS, pH, enzymes, glucose and glutathione), physical microenvironments (mechanical force, temperature, light, ultrasound, magnetic and electric field), and the combination modes. Moreover, several novel promising drug carriers (microbiota, metal-organic frameworks and microneedles) are also discussed.

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Authors: Li, H., Li, B., Lv, D., Li, W., Lu, Y., & Luo, G.
Affiliations: Army Medical University (CN)
First Affiliated Hospital of Wannan Medical College (CN)
Corresponding author: Lu, Yifei
Luo, Gaoxing
ORCID: Li, Haisheng
Li, Buying
Lv, Dalun
Li, Wenhong
Luo, Gaoxing
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2023-05
Volume: 196
Pages: 114778
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2023.114778
OpenAlex: W4324335398
Cited by: 142
References: 227
Citations by year: 2026: 35 · 2025: 53 · 2024: 39 · 2023: 15
FWCI: 4.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (82002036, SZYZTR02)
National Key Research and Development Program of China (2021YFA1101100)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: wound healing, stimuli-responsive biomaterials, drug delivery, wound microenvironment, reactive oxygen species, pH-responsive materials, enzyme-responsive materials, mechanical stimuli, temperature-responsive materials, photoresponsive materials, magnetic field-responsive materials, metal-organic frameworks, microneedles
MeSH terms: Metal-Organic Frameworks, Biocompatible Materials, Drug Carriers, Humans, Wound Healing, Drug Delivery Systems

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Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment

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