Cited by 183Oral microbiology and periodontitis researchBlood Pressure and Hypertension StudiesPeriodontal Regeneration and Treatments

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Association between periodontitis and arterial hypertension: A systematic review and meta-analysis

Martin-Cabezas, Rodrigo, Seelam, Narendra, Petit, Catherine, Agossa, Kévimy, Gaertner, Sébastien, Tenenbaum, Henri, Davideau, Jean-Luc, Huck, Olivier·2016·American Heart Journal

DOI 10.1016/j.ahj.2016.07.018

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Abstract

Background Several studies have shown that periodontal diseases are associated with hypertension (HT). However, heterogeneity among populations, diagnosis criteria, and shared risk factors represent some difficulties in terms of interpretation. Therefore, the aim of this study was to determine the magnitude of the association between periodontal diseases and HT.Methods and results A systematic review and meta-analysis, including studies published up to June 2016, have been performed. Sixteen studies assessing the association between periodontal diseases and HT have been included. The meta-analysis considering all included studies (moderate to severe periodontitis) showed that the presence of HT was associated with the presence of periodontal diseases (OR, 1.50; 95% CI, 1.27-1.78). To reduce potential bias, a stratified analysis has been performed illustrating the impact of inclusion criteria and adjustments on the magnitude of the association. Interestingly, when only studies with secure diagnosis of severe periodontitis and HT were considered, an OR=1.64 (95% CI, 1.23-2.19) has been measured.Conclusions Periodontal diseases are associated with a higher risk of HT especially for severe periodontitis. However, no conclusions could be made regarding the causative involvement of periodontal diseases mainly due to the reduced number of available prospective studies and remaining questions regarding underlying biological mechanisms.

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A potential risk factor of periodontal disease for chronic bronchitis: A nationwide population-based cohort studyPreprint
Shin, H., Hong, M.-H., Moon, J.-Y., & Sim, S. (2024) · Research Square · doi:10.21203/rs.3.rs-3955733/v1
The role of periodontal treatment in comprehensive cardiac rehabilitation
Caloian, C. S., Pop, D., Caloian, B., Ciurea, A., Stanomir, A., Micu, I. C., Șoancă, A., & Roman, A. (2024) · Balneo and PRM Research Journal · doi:10.12680/balneo.2024.675
“The nonsurgical treatment (subgingival mechanical instrumentation) of periodontitis targets to dramatically reduce local infection, and inflammation and thus to decrease the general deleterious effects of periodontitis and improve CVD parameters as some studies reported [23, 24, 25].”
Result
Association of Periodontal Disease with Hypertension in Nigerian Patients: A Comparative Study
Umeizudike, K. A., Abah, A., Umeizudike, T. I., & Amira, C. O. (2024) · PubMed Central · doi:10.60787/nmj-63-3-101
“[8,19] The significant contribution of periodontal disease to systemic inflammatory burden,[1] may amplify the effect/role of inflammation in the pathogenesis of hypertension, and propagate the periodontal-hypertension link.”
Background
Associação entre diabetes e doença periodontal em fases precoces do ciclo vital: revisão narrativa da literatura
Melo, A. B., dos Santos, J. M. V., Morais, E. P. S., Ferreira, E. C. P., Pinheiro, A. M. D. S., Costa, S. A., & Ladeira, L. L. C. (2025) · Caderno Pedagógico · doi:10.54033/cadpedv22n3-005
Additional file 1 of Chronic periodontal disease is related with newly developing hypertension: a nationwide cohort study
Park, J.-H., Kang, M. K., Leem, G. H., Kim, J.-W., & Song, T.-J. (2024) · Figshare · doi:10.6084/m9.figshare.27140881
Additional file 2 of Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study
Čolak, D., Cmok Kučič, A., Pintar, T., Gašpirc, B., & Gašperšič, R. (2022) · Figshare · doi:10.6084/m9.figshare.19766280
Additional file 3 of Cross-sectional study on the association of periodontitis with arterial hypertension in the Hamburg City Health Study
Könnecke, H., Schnabel, R. B., Walther, C., Lamprecht, R., Heydecke, G., Seedorf, U., Jagodzinski, A., Borof, K., Zeller, T., Beikler, T., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151445
Additional file 2 of Chronic periodontal disease is related with newly developing hypertension: a nationwide cohort study
Park, J.-H., Kang, M. K., Leem, G. H., Kim, J.-W., & Song, T.-J. (2024) · Figshare · doi:10.6084/m9.figshare.27140884
Additional file 2 of Cross-sectional study on the association of periodontitis with arterial hypertension in the Hamburg City Health Study
Könnecke, H., Schnabel, R. B., Walther, C., Lamprecht, R., Heydecke, G., Seedorf, U., Jagodzinski, A., Borof, K., Zeller, T., Beikler, T., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151442
Additional file 1 of Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study
Čolak, D., Cmok Kučič, A., Pintar, T., Gašpirc, B., & Gašperšič, R. (2022) · Figshare · doi:10.6084/m9.figshare.19766277
Additional file 1 of Cross-sectional study on the association of periodontitis with arterial hypertension in the Hamburg City Health Study
Könnecke, H., Schnabel, R. B., Walther, C., Lamprecht, R., Heydecke, G., Seedorf, U., Jagodzinski, A., Borof, K., Zeller, T., Beikler, T., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151439
Immune Mechanisms in Cardiac Physiology
deKay, J. T., Tsibulnikov, S. V., Peterson, S. M., Roberts, D. J., & Ryzhov, S. V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00062-5
Inflammations orales et infection par le virus d’Epstein-Barr : vers un nouveau paradigme en pathogenèse orale
Olivieri, C.-V. (2018) · theses.fr (ABES) · doi:10.70675/ce1fe865za4bdz43c1za3f9z7755587225cf
Développement de stratégies de régénération parodontale basées sur le contrôle et la résolution de l'inflammation : études in vivo et in vitro
Petit, C. (2021) · theses.fr (ABES) · doi:10.70675/3bcd4220z1710z4e83za78bz1fe76e0aba56
Causal relationship between oral diseases and hypertension: a Mendelian randomization study
Qian, B., & Fang, Z. (2026) · Experimental Biology and Medicine · doi:10.3389/ebm.2026.10922
Oral Health and Cardiovascular Disease Among Hypertensive Medicated Adults With Uncontrolled Blood Pressure
Kikuchi, Y., Tanaka, F., Tanno, K., Onoda, T., Ohsawa, M., Sakata, K., Omama, S., Ogasawara, K., Yonekura, Y., Kuribayashi, T., et al. (2026) · Journal of Clinical Hypertension · doi:10.1111/jch.70224
“Previous cross-sectional and longitudinal studies have demonstrated associations of periodontal disease and tooth loss with elevated blood pressure (BP) [ 4, 5 ].”
Periodontitis and the risk of elevated blood pressure and hypertension: A two-sample univariable and multivariable Mendelian randomization study
Chen, Y., Li, Y., Xia, L., Yan, Y., Ma, D., Li, Y., Xie, W., Leng, W., & Ma, B. (2026) · Journal of Clinical Insight · doi:10.1016/j.jci.2026.100007
Association Between Arterial Hypertension and Periodontitis: A Systematic Review and Meta-Analysis
Matinyan-Hakobyan, A., González-Navarro, B., Egido‐Moreno, S., Mazza-Padrón, F., Oliveras, A., & López‐López, J. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15155930
“Martin-Cabezas et al. (2016) [10], pooling 16 studies, reported OR 1.50 (95% CI: 1.27–1.78), concluding that periodontitis was significantly associated with increased odds of hypertension, although with substantial heterogeneity and limitations inherent to observational designs.”
Influential
Parodontite de stadeIV gradeC associée à l'hypertension artérielle, au surpoids et au stress
Bessou, L., Tavernier, B., Fontanille, I., & Carra, M. C. (2025) · Elsevier eBooks · doi:10.1016/b978-2-294-78188-9.00005-x
Periodontal Disease and Incident Chronic Bronchitis: A Nationwide Population-Based Cohort Study
Sim, S., Moon, J.-Y., Shin, H., Hong, M.-H., & Kim, S.-M. (2026) · Biomedicines · doi:10.3390/biomedicines14091999
“The clustering of periodontal disease with socioeconomic and cardiometabolic factors highlights the importance of controlling for shared determinants when evaluating periodontal-respiratory associations [9,10,24,25].”

Authors: Martin-Cabezas, R., Seelam, N., Petit, C., Agossa, K., Gaertner, S., Tenenbaum, H., Davideau, J.-L., & Huck, O.
Affiliations: Université de Strasbourg (FR)
Université de Lille (FR)
Hôpitaux Universitaires de Strasbourg (FR)
Inserm (FR)
Corresponding author: Huck, Olivier
ORCID: Petit, Catherine
Agossa, Kévimy
Tenenbaum, Henri
Davideau, Jean-Luc
Huck, Olivier
Venue: American Heart Journal
Publisher: Elsevier BV
Published: 2016-10
Volume: 180
Pages: 98-112
ISSN: 0002-8703 (ISSN-L)
DOI: 10.1016/j.ahj.2016.07.018
OpenAlex: W2487600428
Cited by: 183
References: 58
Citations by year: 2026: 7 · 2025: 6 · 2024: 16 · 2023: 27 · 2022: 25 · 2021: 27 · 2020: 30 · 2019: 18 · 2018: 13 · 2017: 14
FWCI: 2.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Heart Journal (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: periodontitis, hypertension, periodontal disease, severe periodontitis, cardiovascular risk factors, shared risk factors, associative strength
MeSH terms: Humans, Hypertension, Periodontitis, Risk Factors

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Association between periodontitis and arterial hypertension: A systematic review and meta-analysis

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