Population-Based Incidence of Uveal Melanoma in Various Races and Ethnic Groups
Abstract
Purpose To investigate racial/ethnic differences in the development of uveal malignant melanoma in a large population-based study.Design Observational cross-sectional study.Methods With the 1992 to 2000 data that was provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program, we calculated age-adjusted incidence rates of uveal melanoma in various racial/ethnic groups (black, Asian and Pacific Islander, Hispanic, and non-Hispanic white). In addition, we calculated the standard incidence ratio (risk ratio) and 95% confidence interval to describe the differences within these racial/ethnic groups.Results From 1992 to 2000, there were a total of 1352 uveal melanomas that were diagnosed in 11 Surveillance, Epidemiology, and End Results registries with known racial/ethnic groups. The annual age-adjusted incidence (per million population) of uveal melanoma was 0.31 (black), 0.38 (Asian), 1.67 (Hispanic), and 6.02 (non-Hispanic white). The difference in the incidence of uveal melanoma between each racial/ethnic group was highly statistically significant, with the exception of the black versus the Asian population in which there was no statistically significant difference.Conclusion The relative risk of uveal melanoma was 1.2 for Asian and Pacific Islander patients, 5.4 for Hispanic patients, and 19.2 for non-Hispanic white patients as compared with the black patients. If the non-Hispanic white population and the Hispanic population were combined, then the overall white:black ratio was 18:1.
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Melanoma is associated with UV light exposure and European ancestry, occurring at very low rates in Africans, African Americans, and light-skinned Asians.
“Incidentally, melanoma is not only associated with UV light exposure but also with European ancestry, occurring at very low rates in Africans, African Americans, and even light-skinned Asians (32)(33)(34).”
From Evidence for recent, population-specific evolution of the human mutation rate (2015) · cites this paper as [33]
Melanoma incidence in admixed Hispanics is strongly correlated with European ancestry.
“Melanoma incidence in admixed Hispanics is strongly correlated with European ancestry (33)(34)(35).”
From Evidence for recent, population-specific evolution of the human mutation rate (2015) · cites this paper as [33]
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- Authors
- Hu, D.-N., Yu, G.-P., McCormick, S. A., Schneider, S., & Finger, P. T.
- Affiliations
- New York Eye and Ear Infirmary (US)
- New York Medical College (US)
- Corresponding author
- Hu, Dan-Ning
- Venue
- American Journal of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 140
- Issue
- 4
- Pages
- 612.e1-612.e8
- ISSN
- 0002-9394 (ISSN-L)
- OpenAlex
- W2061857205
- Cited by
- 238
- References
- 36
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 17 · 2023: 17 · 2022: 16 · 2021: 15 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 14 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 17 · 2012: 11
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- uveal melanoma, racial and ethnic differences, cancer incidence, age-adjusted incidence, Hispanic population, Asian and Pacific Islander populations, Black population, non-Hispanic whites, SEER database, relative risk
- MeSH terms
- Cross-Sectional Studies, Ethnicity, Female, Humans, Male, Melanoma, Risk Factors, United States, Uveal Neoplasms, Incidence, SEER Program, Racial Groups
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