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Cited by 255Obstructive Sleep Apnea ResearchOrthodontics and Dentofacial OrthopedicsNasal Surgery and Airway Studies

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Craniofacial and upper airway morphology in pediatric sleep-disordered breathing: Systematic review and meta-analysis

Katyal, Vandana, Pamula, Yvonne, Martin, A. James, Daynes, Cathal N., Kennedy, J. Declan, Sampson, Wayne J.·2013·American Journal of Orthodontics and Dentofacial Orthopedics
DOI 10.1016/j.ajodo.2012.08.021
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Abstract

Introduction Pediatric sleep-disordered breathing is a continuum, with primary snoring at one end, and complete upper airway obstruction, hypoxemia, and obstructive hypoventilation at the other. The latter gives rise to obstructive sleep apnea. An important predisposing factor in the development and progression of pediatric sleep-disordered breathing might be craniofacial disharmony. The purpose of this systematic review and meta-analysis was to elucidate the association between craniofacial disharmony and pediatric sleep-disordered breathing.Methods Citations to potentially relevant published trials were located by searching PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials. The MetaRegister of controlled trials database was also searched to identify potentially relevant unpublished trials. Additionally, hand-searching, Google Scholar searches, and contact with experts in the area were undertaken to identify potentially relevant published and unpublished studies. Inclusion criteria were (1) randomized controlled trials, case-control trials, or cohort studies with controls; (2) studies in nonsyndromic children 0 to 18 years of age with a diagnosis of sleep-disordered breathing or obstructive sleep apnea by either a sleep disorders unit, screening questionnaire, or polysomnography; and (3) principal outcome measures of craniofacial or upper airway dimensions or proportions with various modalities of imaging for the craniofacial and neck regions. The quality of the studies selected was evaluated by assessing their methodologies. Treatment effects were combined by meta-analysis with the random-effects method.Results Children with obstructive sleep apnea and primary snoring show increased weighted mean differences in the ANB angle of 1.64° (P <0.0001) and 1.54° (P <0.00001), respectively, compared with the controls. An increased ANB angle was primarily due to a decreased SNB angle in children with primary snoring by 1.4° (P = 0.02). Children with obstructive sleep apnea had a distance from the posterior nasal spine to the nearest adenoid tissue measured along the PNS-basion line reduced by 4.17 mm (weighted mean difference) (P <0.00001) and a distance from the posterior nasal spine to the nearest adenoid tissue measured along the line perpendicular to the sella-basion line reduced by 3.12 mm (weighted mean difference) (P <0.0001) compared with the controls.Conclusions There is statistical support for an association between craniofacial disharmony and pediatric sleep-disordered breathing. However, an increased ANB angle of less than 2° in children with obstructive sleep apnea and primary snoring, compared with the controls, could be regarded as having marginal clinical significance. Therefore, evidence for a direct causal relationship between craniofacial structure and pediatric sleep-disordered breathing is unsupported by this meta-analysis. There is strong support for reduced upper airway width in children with obstructive sleep apnea. Larger well-controlled trials are required to address the relationship of craniofacial and upper airway morphology to pediatric sleep-disordered breathing in all 3 dimensions.

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  1. Pracharktam, 1994, Upright and supine cephalometric evaluation of obstructive sleep apnea syndrome and snoring subjects, Angle Orthod, 64, 63

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Metadata

Authors
Katyal, V., Pamula, Y., Martin, A. J., Daynes, C. N., Kennedy, J. D., & Sampson, W. J.
Affiliations
  • The University of Adelaide (AU)
  • Women's and Children's Hospital (AU)
  • The University of Sydney (AU)
ORCID
Venue
American Journal of Orthodontics and Dentofacial Orthopedics
Publisher
Elsevier BV
Published
2013-01
Volume
143
Issue
1
Pages
20-30.e3
ISSN
0889-5406 (ISSN-L)
DOI
10.1016/j.ajodo.2012.08.021
OpenAlex
W2060176797
Cited by
255
References
50
Citations by year
2026: 17 · 2025: 15 · 2024: 14 · 2023: 26 · 2022: 26 · 2021: 18 · 2020: 26 · 2019: 19 · 2018: 11 · 2017: 22 · 2016: 17 · 2015: 16 · 2014: 20 · 2013: 7
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Orthodontics and Dentofacial Orthopedics (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
  • Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
Keywords
pediatric sleep-disordered breathing, obstructive sleep apnea, upper airway morphology, primary snoring, ANB angle, SNB angle, posterior nasal spine, adenoids, airway obstruction, children, craniofacial imaging, posterior fossa volume, airway cross-sectional area
MeSH terms
Adenoids, Adolescent, Cephalometry, Child, Child, Preschool, Humans, Hypertrophy, Infant, Larynx, Nose, Pharynx, Sleep Apnea Syndromes, Likelihood Functions, Sleep Apnea, Obstructive

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