Cited by 280Coffee research and impactsPregnancy and Medication ImpactReproductive System and Pregnancy

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Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study

Weng, Xiaoping, Odouli, Roxana, Li, De-Kun·2008·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2007.10.803

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Abstract

Objective The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms.Study design This was a population-based prospective cohort study.Results An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94).Conclusion Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.

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Authors: Weng, X., Odouli, R., & Li, D.-K.
Affiliations: Kaiser Permanente (US)
Corresponding author: Li, De-Kun
ORCID: Li, De-Kun
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2008-03
Volume: 198
Issue: 3
Pages: 279.e1-279.e8
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2007.10.803
OpenAlex: W1973666876
Cited by: 279
References: 24
Citations by year: 2026: 5 · 2025: 7 · 2024: 14 · 2023: 10 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 35 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 10 · 2012: 15
FWCI: 16.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Funders: Kaiser Permanente
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: caffeine consumption, pregnancy, miscarriage, nausea and vomiting of pregnancy, history of miscarriage, maternal diet
MeSH terms: Abortion, Spontaneous, Adult, Beverages, Caffeine, Female, Humans, Pregnancy, Prospective Studies, Risk Factors

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Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study

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