Caffeine and miscarriage risk
Abstract
BACKGROUND: Coffee and caffeine have been inconsistently found to be associated with increased risk of clinical miscarriage-a potentially important association given the high prevalence of exposure. METHODS: Women were recruited before or early in pregnancy and interviewed regarding sources of caffeine, including assessment of changes over the perinatal period. We identified 2407 clinically-recognized pregnancies resulting in 258 pregnancy losses. We examined the relationship of coffee and caffeine intake with clinically-recognized pregnancy loss prior to 20 weeks' completed gestation, using a discrete-time continuation ratio logistic survival model. RESULTS: Coffee and caffeine consumption at all 3 time points were unrelated to total miscarriage risk and the risk of loss after the interview. Reported exposure at the time of the interview was associated with increased risk among those with losses before the interview. CONCLUSIONS: There is little indication of possible harmful effects of caffeine on miscarriage risk within the range of coffee and caffeine consumption reported, with a suggested reporting bias among women with losses before the interview. The results may reflect exposure misclassification and unmeasured heterogeneity of pregnancy losses.
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Savitz et al. reported no association among 2407 women who were interviewed regarding caffeine intake before experiencing spontaneous abortion.
“However, Savitz et al. (128) reported no association among 2407 women who were interviewed regarding caffeine intake before experiencing spontaneous abortion (128).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [128]
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- Authors
- Savitz, D. A., Chan, R. L., Herring, A. H., Howards, P. P., & Hartmann, K. E.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- National Institutes of Health (US)
- Vanderbilt University (US)
- Corresponding author
- Savitz, David A.
- Venue
- Epidemiology
- Published
- 2008-01
- Volume
- 19
- Issue
- 1
- Pages
- 55-62
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W1988293121
- Cited by
- 77
- References
- 23
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (ES 07018)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- caffeine, coffee consumption, miscarriage, perinatal exposure, exposure misclassification, reporting bias
- MeSH terms
- Abortion, Spontaneous, Adolescent, Adult, Caffeine, Coffee, Female, Humans, Interviews as Topic, Middle Aged, North Carolina, Nutrition Surveys, Pregnancy, Risk Factors, Tennessee, Texas, Odds Ratio
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