The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia
Open accessAbstract
OBJECTIVE To examine associations of fasting C-peptide, BMI, and maternal glucose with risk of preeclampsia, in a multicenter multinational study. STUDY DESIGN Secondary analysis of blinded observational cohort study. Subjects underwent a 75-g OGTT at 24–32 weeks gestation. Associations of preeclampsia with fasting C-peptide, BMI, and maternal glucose were assessed using multiple logistic regression analyses, adjusting for potential confounders. RESULTS Of 21,364 women included in analyses, 5.2% developed preeclampsia. Adjusted odds ratios (OR) for preeclampsia for 1 SD higher fasting C-peptide (0.87 ug/L), BMI (5.1 kg/m2), fasting (6.9 mg/dl), 1-hour (30.9 mg/dl), and 2-hour plasma glucose (23.5 mg/dl) were 1.28 (1.20, 1.36), 1.60 (95% CI 1.60–1.71), 1.08 (95% CI 1.00–1.16), 1.19 (95% CI 1.11–1.28), and 1.21 (1.13–1.30), respectively. CONCLUSION Results indicate strong, independent associations of fasting C-peptide and BMI with preeclampsia. Maternal glucose levels (below diabetes) had weaker associations with preeclampsia, particularly after adjustment for fasting C-peptide and BMI.
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“Some secondary outcomes, including risks of shoulder dystocia and/or birth injury and preeclampsia, were also associated with maternal glycemia (257).”
From Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus (2023) · cites this paper as [257]
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Cites
(2000) · PubMed · Cited by 13,173
Obesity : Preventing and managing the global epidemic
Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J.-L., Bray, G. A., Carroll, K. N., Chitson, P., Chen, C., Dietz, W. H., Hill, J. O., et al. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 12,945
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563
International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010) · Diabetes Care · doi:10.2337/dc09-1848 · Cited by 5,390
Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes
Crowther, C. A., Hiller, J. E., Moss, J. R., McPhee, A. J., Jeffries, W. S., & Robinson, J. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042973 · Cited by 3,159
The Global Impact of Pre-eclampsia and Eclampsia
Duley, L. (2009) · Seminars in Perinatology · doi:10.1053/j.semperi.2009.02.010 · Cited by 2,866
M-Type Phospholipase A 2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy
Beck, L. H., Bonegio, R. G. B., Lambeau, G., Beck, D. M., Powell, D. W., Cummins, T. D., Klein, J. B., & Salant, D. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810457 · Cited by 2,347
A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes
Landon, M. B., Spong, C. Y., Thom, E., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902430 · Cited by 2,122
Onuegbu, A. J., Olisekodiaka, J. M., Udo, J., Umeononihu, O. S., Amah, U. K., Okwara, J. E., & Atuegbu, C. (2015) · Medical Principles and Practice · doi:10.1159/000381778 · Cited by 2,057
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Preeclampsia, a Disease of the Maternal Endothelium
Powe, C. E., Levine, R. J., & Karumanchi, S. A. (2011) · Circulation · doi:10.1161/circulationaha.109.853127 · Cited by 987
(2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.10.012 · Cited by 914
The Hyperglycemia and Adverse Pregnancy Outcome Study
Catalano, P. M., McIntyre, H. D., Cruickshank, J. K., McCance, D. R., Dyer, A. R., Metzger, B. E., Lowe, L. P., Trimble, E. R., Coustan, D. R., Hadden, D. R., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1790 · Cited by 954
Self-citationWendland, E. M., Torloni, M. R., Falavigna, M., Trujillo, J., Dode, M. A., Campos, M. A., Duncan, B. B., & Schmidt, M. I. (2012) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-12-23 · Cited by 626
Lee, K. W., Ching, S. M., Ramachandran, V., Yee, A., Hoo, F. K., Chia, Y. C., Wan Sulaiman, W. A., Suppiah, S., Mohamed, M. H., & Veettil, S. K. (2018) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-018-2131-4 · Cited by 546
Metadata
- Authors
- Yogev, Chen, Hod, Coustan, Oats, McIntyre, D. H., Metzger, Löwe, Dyer, Dooley, Trimble, McCance, Hadden, Persson, & Rogers
- Affiliations
- Tel Aviv University (IL)
- ORCID
- David H. McIntyre
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 202
- Issue
- 3
- Pages
- 255.e1-255.e7
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC2836485
- OpenAlex
- W17552291
- Semantic Scholar
- 34ba55362b70dc07b0d905a30c069b1248740e6f
- Cited by
- 155
- References
- 38
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 14 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 14
- FWCI
- 15.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- National Center for Research Resources (M01-RR00048, M01-RR00080)
- Royal College of Physicians of Edinburgh
- Diabetes UK (RD04/0002756)
- American Diabetes Association
- Novo Nordisk
- National Institute of Child Health and Human Development
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-HD34242, R01-HD34243)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- preeclampsia, fasting C-peptide, body mass index, maternal blood glucose, oral glucose tolerance test, hyperglycemia, adverse pregnancy outcomes, insulin resistance, gestational diabetes mellitus
- MeSH terms
- Adult, Blood Glucose, C-Peptide, Fasting, Female, Glucose Tolerance Test, Humans, Hyperglycemia, Pre-Eclampsia, Pregnancy, Cohort Studies, Body Mass Index, Logistic Models
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