The DOI matches its Crossref record; 88 of the 90 references it cites were found in a registry or an index.
Current Knowledge of Obesity’s Effects in the Pre-and Periconceptional Periods and Avenues for Future Research
Open accessAbstract
The prevalence of obesity is growing among reproductive-age women. This is concerning because obesity has significant health-related consequences. Aside from the long-term risks of diabetes, heart disease, and some types of cancer, obesity poses immediate threats for young women including subfertility and adverse early and late pregnancy outcomes. Epidemiologic and experimental studies demonstrate associations between prepregnancy obesity and poor reproductive outcomes; however, the mechanisms involved are poorly understood. We discuss current knowledge of the pathophysiology of obesity in early reproductive events and how these events may affect reproductive outcomes including fertility and miscarriage risk. We also discuss avenues for future research and interventions to improve reproductive outcomes for obese women.
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“Furthermore, adipocytes are responsible for the functional alteration of the hypothalamic-pituitary-ovarian (HPO) axis due to aromatization of androgens to estrogens, which by negative feedback loop, suppress gonadotropin production [84,86].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [86]
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(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132
Clinical gynecologic endocrinology and infertility
Fritz, M. A., & Speroff, L. (1983) · Cited by 2,099
Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M., Graubard, B. I., Williamson, D. F., & Gail, M. H. (2007) · JAMA · doi:10.1001/jama.298.17.2028 · Cited by 1,542
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61345-2 · Cited by 1,360
Maternal Morbid Obesity and the Risk of Adverse Pregnancy Outcome
Cedergren, M. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000107291.46159.00 · Cited by 1,352
Maternal Overweight and Obesity and the Risk of Congenital Anomalies
Stothard, K. J., Tennant, P. W. G., Bell, R., & Rankin, J. M. (2009) · JAMA · doi:10.1001/jama.2009.113 · Cited by 1,290
Obesity, obstetric complications and cesarean delivery rate–a population-based screening study
Weiss, J. L., Malone, F. D., Emig, D., Ball, R. H., Nyberg, D. A., Comstock, C. H., Saade, G. R., Eddleman, K. A., Carter, S. M., Craigo, S., et al. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2003.09.058 · Cited by 1,136
Research works printed but not linked: 1
- 2005, Obesity in pregnancy, Obstet Gynecol, 106, 671
Cited by
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Obesity and female infertility: potential mediators of obesity's impact
Broughton, D. E., & Moley, K. H. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.017 · Cited by 845
Self-citationSex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513
Sermondade, N., Huberlant, S., Bourhis-Lefebvre, V., Arbo, E., Gallot, V., Colombani, M., & Fréour, T. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz011 · Cited by 397
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists
Cena, H., Chiovato, L., & Nappi, R. E. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa285 · Cited by 356
Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization
Shah, D. K., Missmer, S. A., Berry, K. F., Racowsky, C., & Ginsburg, E. S. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821fd360 · Cited by 275
Metadata
- Authors
- Jungheim, E. S., & Moley, K. H.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 203
- Issue
- 6
- Pages
- 525-530
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3718032
- OpenAlex
- W1976745100
- Cited by
- 190
- References
- 90
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 16 · 2023: 8 · 2022: 13 · 2021: 20 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 17 · 2014: 14 · 2013: 13 · 2012: 13
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K12HD063086-01)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- obesity, pre-pregnancy obesity, periconceptional period, female fertility, subfertility, miscarriage risk, adverse pregnancy outcomes, women of reproductive age, obesity pathophysiology
- MeSH terms
- Female, Fertility, Forecasting, Humans, Health Knowledge, Attitudes, Practice, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Research, Severity of Illness Index, Body Mass Index, Preconception Care, Risk Assessment, Reproductive Techniques, Assisted, Fetal Development
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