Cited by 190Gestational Diabetes Research and ManagementOvarian function and disordersReproductive Health and Technologies

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Current Knowledge of Obesity’s Effects in the Pre-and Periconceptional Periods and Avenues for Future Research

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Jungheim, Emily S., Moley, Kelle H.·2010·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2010.06.043PMC PMC3718032

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Abstract

The prevalence of obesity is growing among reproductive-age women. This is concerning because obesity has significant health-related consequences. Aside from the long-term risks of diabetes, heart disease, and some types of cancer, obesity poses immediate threats for young women including subfertility and adverse early and late pregnancy outcomes. Epidemiologic and experimental studies demonstrate associations between prepregnancy obesity and poor reproductive outcomes; however, the mechanisms involved are poorly understood. We discuss current knowledge of the pathophysiology of obesity in early reproductive events and how these events may affect reproductive outcomes including fertility and miscarriage risk. We also discuss avenues for future research and interventions to improve reproductive outcomes for obese women.

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Broughton, D. E., & Moley, K. H. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.017 · Cited by 845
Self-citation
Sex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513
Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis
Sermondade, N., Huberlant, S., Bourhis-Lefebvre, V., Arbo, E., Gallot, V., Colombani, M., & Fréour, T. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz011 · Cited by 397
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists
Cena, H., Chiovato, L., & Nappi, R. E. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa285 · Cited by 356
Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization
Shah, D. K., Missmer, S. A., Berry, K. F., Racowsky, C., & Ginsburg, E. S. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821fd360 · Cited by 275

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Authors: Jungheim, E. S., & Moley, K. H.
Affiliations: Washington University in St. Louis (US)
ORCID: Jungheim, Emily S.
Moley, Kelle H.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2010-12
Volume: 203
Issue: 6
Pages: 525-530
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2010.06.043
PMC: PMC3718032
OpenAlex: W1976745100
Cited by: 190
References: 90
Citations by year: 2026: 4 · 2025: 11 · 2024: 16 · 2023: 8 · 2022: 13 · 2021: 20 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 17 · 2014: 14 · 2013: 13 · 2012: 13
FWCI: 1.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (K12HD063086-01)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords: obesity, pre-pregnancy obesity, periconceptional period, female fertility, subfertility, miscarriage risk, adverse pregnancy outcomes, women of reproductive age, obesity pathophysiology
MeSH terms: Female, Fertility, Forecasting, Humans, Health Knowledge, Attitudes, Practice, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Research, Severity of Illness Index, Body Mass Index, Preconception Care, Risk Assessment, Reproductive Techniques, Assisted, Fetal Development

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Current Knowledge of Obesity’s Effects in the Pre-and Periconceptional Periods and Avenues for Future Research

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