The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
The “Great Obstetrical Syndromes” are associated with disorders of deep placentation
Open accessAbstract
Defective deep placentation has been associated with a spectrum of complications of pregnancy including preeclampsia, intrauterine growth restriction, preterm labor, preterm premature rupture of membranes, late spontaneous abortion, and abruptio placentae. The disease of the placental vascular bed that underpins these complications is commonly investigated with targeted biopsies. In this review, we critically evaluate the biopsy technique to summarize the salient types of defective deep placentation, and propose criteria for the classification of defective deep placentation into 3 types based on the degree of restriction of remodeling and the presence of obstructive lesions in the myometrial segment of the spiral arteries.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Inadequate placentation is seen in several common obstetrical syn dromes, including fetal growth restriction, spontaneous second trimester miscarriages, placental abruption, preterm birth, and hyper tensive disorders in pregnancy (Brosens et al., 2011).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Brosens et al., 2011
In the citing paper
“Failure of trophoblast invasion and arterial remodeling is associated with the 'Great Obstetrical Syndromes', including growth restriction, pre-eclampsia and late spontaneous abortion, due to impaired maternal perfusion (64).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Circulating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics and Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,623
Soluble endoglin contributes to the pathogenesis of preeclampsia
Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855
Self-citationSoluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia
Levine, R. J., Lam, C., Qian, C., Yu, K. F., Maynard, S. E., Sachs, B. P., Sibai, B. M., Epstein, F. H., Romero, R. J., Thadhani, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055352 · Cited by 1,823
Self-citationKHONG, T. Y., DE WOLF, F., ROBERTSON, W. B., & BROSENS, I. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07830.x · Cited by 1,591
Self-citationThe preterm parturition syndrome
Romero, R., Espinoza, J., Kusanovic, J., Gotsch, F., Hassan, S., Erez, O., Chaiworapongsa, T., & Mazor, M. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01120.x · Cited by 1,419
Self-citationAssociation of young maternal age with adverse reproductive outcomes.
Fraser, A., Brockert, J. E., & Ward, R. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504273321701 · Cited by 1,078
The role of the spiral arteries in the pathogenesis of pre-eclampsia.
Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1970) · PubMed · Cited by 953
Self-citationBoyd, J. D., & Hamilton, W. J. (1970) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-02807-8 · Cited by 948
Research works printed but not linked: 2
- Brosens, 1972, The role of the spiral arteries in the pathogenesis of preeclampsia, Obstet Gynecol Annu, 1, 177
- Robson, 2001, Endovascular trophoblast invasion and spiral artery transformation: the ”two wave” theory revisited, Placenta, 22, A25
Cited by
Sorted by citations
Items 901–999 of 999
Bujold, E., Rolnik, D. L., Poon, L. C., Syngelaki, A., Wright, D. E., & Nicolaides, K. H. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2025.10.032 · Cited by 7
Baschat, A., Darwin, K. C., & Vaught, A. “. J. (2023) · American Journal of Perinatology · doi:10.1055/a-2051-2127 · Cited by 8
“36 Placental ischemia resulting from abnormal spiral artery transformation is thought to lead to widespread activation of factors that promote vasoconstriction and vascular reactivity while vaso-dilators are downregulated.”
BackgroundYokouchi-Konishi, T., Liu, Y., & Feng, L. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad109 · Cited by 7
“Abnormal placental development is the primary defect in major pregnancy complications, such as pregnancy loss, preeclampsia, fetal growth restriction, and stillbirth [1].”
BackgroundChen, X., Gissler, M., & Lavebratt, C. (2023) · Human Reproduction Open · doi:10.1093/hropen/hoad048 · Cited by 7
“In mothers with pre-eclampsia, more preterm births were also expected for those with PCOS, as both disorders are associated with placental dysfunction and increased androgens (Brosens et al. , 2011; Kelley et al. , 2019).”
BackgroundHua, Q., Li, Z., Zhou, Y., Wang, Y., Yu, Y., Sun, L., Ye, J., & Li, L. (2023) · Placenta · doi:10.1016/j.placenta.2023.12.022 · Cited by 7
Aspirin dosage for preeclampsia prophylaxis: an argument for 81-mg dosing
Balhotra, K. S., & Sibai, B. M. (2024) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2024.101568 · Cited by 8
Feng, H., Tian, C., Jiang, W., Sun, Z., Li, Y., Han, B., Chen, L., Wang, D., Xiang, H., Zhu, J., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140240 · Cited by 8
Placental Development, Evolution, and Epigenetics of Primate Pregnancies
Sterner, K. N., Jameson, N. M., & Wildman, D. E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4060-4_3 · Cited by 8
İncebıyık, A., Vural, M., Camuzcuoğlu, A., Camuzcuoğlu, H., Hilali, N. G., Taşkın, A., Aydın, H., & Aksoy, N. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3481-4 · Cited by 7
The Clinical Spectrum of Preeclampsia
Cunningham, F. G., Roberts, J. M., & Lindheimer, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374213-1.00002-1 · Cited by 7
Zamir, M., Nelson, D. M., & Ginosar, Y. (2018) · Placenta · doi:10.1016/j.placenta.2018.06.006 · Cited by 8
Preda, A. P., Caracostea, G. V., Ona, D., Zaharie, G. C., & Stamatian, F. V. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1517311 · Cited by 7
“This gene is implicated in angiogenic process and it is possible that angiogenesis may be involved in the occurrence of typical malperfusion lesions [37,38] and in preterm parturition [39].”
BackgroundBhorat, I. E., Pillay, M., & Reddy, T. (2018) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2018-036 · Cited by 7
“Placental-mediated disease, which is an umbrella term for describing different clinical phenotypes, including intra-uterine growth restriction (IUGR), pre-eclampsia (PE) and abruptio placentae, arises from a single pathophysiological event in the first trimester relating to placental maladaptation and lack of vascular…”
BackgroundVolodarsky‐Perel, A., Nu, T. N. T., Buckett, W. M., Machado-Gédéon, A., Cui, Y., Shaul, J., & Dahan, M. H. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.08.002 · Cited by 7
Kacerovský, M., Matulová, J., Andrýs, C., Mls, J., Hornychová, H., Kukla, R., Boštík, P., Burčková, H., Špaček, R., Jacobsson, B., et al. (2021) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2021.2017875 · Cited by 7
The effects of aspartame on the HTR8/SVneo extravillous trophoblast cell line
Rodrigues, H., Silva, C., & Martel, F. (2022) · Reproductive Biology · doi:10.1016/j.repbio.2022.100678 · Cited by 7
Hussein, S., Ju, W., Pizzella, S., Flory, M. J., Chu, C., Wang, Y., & Zhong, N. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1024587 · Cited by 7
Bai, L., Guo, Y., Gong, J., Li, Y., Huang, H., Meng, Y., & Liu, X. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1078166 · Cited by 7
“Decreased trophoblast cell invasion and vascular conversion resulting in poor placental perfusion may lead to the development of preeclampsia (Brosens et al., 2011).”
BackgroundThe impact of risk factors on aspirin's efficacy for the prevention of preterm birth
Nuss, E., Hoffman, M., Goudar, S. S., Kavi, A. J., Metgud, M. C., Somannavar, M. S., Okitawutshu, J., Lokangaka, A. L., Tshefu, A. K., Bauserman, M., et al. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.101095 · Cited by 7
Im, D. H., Kim, Y. N., Cho, H. J., Park, Y., Kim, D. H., Byun, J. M., Jeong, D. H., Lee, K. B., & Sung, M. S. (2020) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2020.1723147 · Cited by 7
Levy, M., Kovo, M., Feldstein, O., Dekalo, A., Schreiber, L., Levanon, O., Bar, J., & Weiner, E. (2020) · Placenta · doi:10.1016/j.placenta.2020.11.009 · Cited by 7
Weinberg, D. H. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.11.002 · Cited by 7
Liu, X., Su, L., Xu, B., Lei, J., & Zhang, H. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11319 · Cited by 7
“Normal trophoblast cells play a critical role in fetal growth, but failure in trophoblast transformation or impaired trophoblast function can lead to RSA (22).”
BackgroundThe role of ADAMTS genes in preeclampsia
Gökdemir, İ. E., Evliyaoğlu, Ö., & Çoşkun, B. (2016) · Journal of Turkish Society of Obstetric and Gynecology · doi:10.4274/tjod.57701 · Cited by 7
Interobserver Agreement in the Study of 2D and 3D Sonographic Criteria for Adenomyosis
Puente, J. M., Alcázar, J. L., Martínez-Ten, P., Bermejo, C., Troncoso, M. T., & García-Velasco, J. A. (2017) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/jeppd.5000295 · Cited by 7
Li, Y., Ge, L., Yang, X., Cui, L., & Chen, Z. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1248274 · Cited by 6
Liang, S., Chen, Y., Jia, T., Chang, Y., Li, W., Piao, Y., & Chen, X. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15876 · Cited by 6
How can artificial intelligence models advance placental biology?
Chou, T., & Goldstein, J. A. (2025) · Placenta · doi:10.1016/j.placenta.2025.03.010 · Cited by 6
Hypertensive disorders of pregnancy and neuroimaging markers of dementia risk: A pilot study
Alshikho, M. J., Haghighi, N., Ravi, R., Solomon, V. A., Rangel, E., Pyne, J. D., Bista, K. C., Chang, J. F., Lippert, R. V., Cotton‐Samuel, D., et al. (2025) · Pregnancy · doi:10.1002/pmf2.70020 · Cited by 7
“The additional adverse pregnancy outcomes were chosen as exclusion criteria due to their shared pathophysiological characteristics with HDP, specifically vascular placental dysfunction [36].”
The frequency of placental lesions and adverse pregnancy outcomes: a linked cohort study
Marijnen, M. C., Oudejans, C. J. M., Freedman, A. A., Ernst, L. M., Ganzevoort, W., Schoots, M. H., van der Meeren, L. E., & Gordijn, S. J. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2025.06.004 · Cited by 6
Bellissimo, C. J., Beristain, A. G., & Sloboda, D. M. (2025) · Reproduction · doi:10.1530/rep-24-0464 · Cited by 8
Qiu, Y., Chen, M., Lin, R. H., Chen, X., He, L., Yin, H., & Chen, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1703156 · Cited by 7
Bastías, C. S., Dean, M., & Luetkemeyer, C. M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.11.026 · Cited by 6
Engineering the Human Endometrial–Embryo Interface: Breakthroughs in 3D Uterine Models
Douglas, J. A., Higgins, J., Wimalasiri, D. H., Winship, A., & Fitzgerald, H. C. (2026) · Biomolecules · doi:10.3390/biom16030383 · Cited by 6
“Placental dysfunction contributes to pregnancy complications such as pre-eclampsia, fetal growth restriction, and pre-term labour, among others [125,126].”
Feasibility of three dimensional power Doppler ultrasonography methods to assess placental perfusion
Schiffer, V. M. M. M., Pellaers, D., Hoenen, J. L. J. M., van Kuijk, S. M. J., Spaanderman, M. E. A., & Al‐Nasiry, S. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.08.006 · Cited by 6
Placental histopathology and pregnancy outcome in placental abruption
Kovo, M., & Schreiber, L. (2021) · Thrombosis Update · doi:10.1016/j.tru.2021.100087 · Cited by 8
Resta, S., Scandella, G., Mappa, I., Pietrolucci, M. E., Maqina, P., & Rizzo, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195793 · Cited by 6
“Recent meta-analysis studies have confirmed how pregnancies obtained from IVF techniques are associated with an increased risk of poor obstetric outcome including: miscarriage, chromosomal abnormalities, PE, PTB, FGR), placenta previa, abruptio placentae, post-partum haemorrhages, as well as peri and postnatal complic…”
BackgroundInfluentialYi, J., Chen, L., Meng, X., & Chen, Y. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2144642 · Cited by 6
“ondary to defective remodelling of the uterine spiral arteries [8], in contrast, the LP is characterized by an”
BackgroundSong, W., Li, C., Wu, T., Wang, Z., Dang, Y., Ding, L., & Qin, Y. (2023) · Human Reproduction · doi:10.1093/humrep/dead220 · Cited by 6
Tu, Y., Li, Y., Fan, X., Gui, Z., Dai, J., Fang, Q., Qiu, T., Bai, J., & Liu, Y. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111092 · Cited by 6
Palma, C., Lai, A., Scholz‐Romero, K., Chittoory, H., Haeringen, B. V., Carrión, F., Handberg, A., Lappas, M., Lakhani, S. R., Reed, A. E. M., et al. (2024) · Journal of Extracellular Biology · doi:10.1002/jex2.135 · Cited by 5
“However, communication can be profoundly disturbed by factors affecting placentation, which can lead to the development of pregnancy complications (Baschat, 2011; Brosens et al., 2011; Burton et al., 2009; Jauniaux et al., 2003; Jauniaux et al., 2006).”
BackgroundKim, Y., Sung, J., Cha, H., & Oh, S. (2024) · Obstetrics & Gynecology Science · doi:10.5468/ogs.23252 · Cited by 9
“Brosens et al. [9] referred to these as “great obstetric syndromes” and focused on the key role of placentation.”
BackgroundPalanisamy, T. B., & Arumugam, M. (2024) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2024.104236 · Cited by 6
Omoto, T., Kyozuka, H., Murata, T., Fukuda, T., Isogami, H., Okoshi, C., Yasuda, S., Yamaguchi, A., Satô, A., Ogata, Y., et al. (2024) · Pregnancy Hypertension · doi:10.1016/j.preghy.2024.101139 · Cited by 6
Sadiku, E., Sun, L., Macgowan, C. K., Seed, M., & Morrison, J. L. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1426593 · Cited by 6
“As such, variable hemodynamic forces caused by faulty fetoplacental vasculature formation may hinder necessary regulatory mechanisms to prevent FGR and CHD, among other developmental abnormalities (5, 8, 13).”
BackgroundWei, L., Zhang, Q., Ni, M., Li, B., Chen, Z., Shen, Q., Lin, Z., Cheng, C.-Y., Yao, D., Qi, S., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05467-x · Cited by 6
“Consequently, the use of assisted reproductive and invasion of trophoblasts would lead to irregular spiral artery remodeling and impaired material exchange between the fetus and mother [7– 10 ].”
Papastefanou, I., Chen, Y.-Y., Nguyen‐Hoang, L., Nguyen, D., Dinh, L. T., Pooh, R. K., Shiozaki, A., Zheng, M., Hu, Y., Wu, Y.-P., et al. (2025) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.18211 · Cited by 6
Erkenekli, K., İskender, C., Öztaş, E., Ozgu-Erdinc, A. S., Yücel, A., & Uygur, D. (2015) · Hypertension in Pregnancy · doi:10.3109/10641955.2015.1090580 · Cited by 6
Endometriosis and obstetric syndromes: early diagnosis must become a priority
Brosens, I. A., Benagiano, G., & Brosens, J. J. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.010 · Cited by 6
Self-citationThe role of endothelial dysfunction in fetal growth restriction
Башмакова, Н. В., Tsyv’yan, P. B., Chistyakova, G. N., Dankova, I. V., Trapeznikova, Y. M., & Chukanova, A. N. (2017) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush201717321-26 · Cited by 6
Uterine Artery Pulsatility Index Assessment at <11 Weeks’ Gestation: A Prospective Study
Taylor, T. J., Quinton, A. E., de Vries, B. S., & Hyett, J. A. (2019) · Fetal Diagnosis and Therapy · doi:10.1159/000500776 · Cited by 6
Genetic hypothesis for the developmental origins of health and disease theory
Zhao, X. (2020) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000056 · Cited by 6
Tairy, D., Weiner, E., Kovo, M., Zamir, A. M., Gandelsman, E., Levy, M., Herman, H. G., Volpert, E., Schreiber, L., Bar, J., et al. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00373-6 · Cited by 6
The implications of the purinergic signaling throughout pregnancy
Sagrillo‐Fagundes, L., Paim, T. C., Pretto, L., Bertaco, I., Zanatelli, C., Vaillancourt, C., & Wink, M. R. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30594 · Cited by 6
“Pre‐eclampsia and gestational diabetes mellitus (GDM) are part of the “great obstetrical syndromes,” common complications of pregnancy, that are associated with defective placentation (Brosens et al., 2011; Jarmuzek et al., 2015).”
BackgroundLi, Y., Feng, J., Bian, Y., Cheng, W., & Qiao, C. (2022) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2022.0001 · Cited by 6
“Human pregnancy is characterized by deep placentation, in which trophoblast cells in the placental bed invade not only the decidua but also one-third the thickness of the myometrium [14].”
BackgroundObstetric and perinatal outcomes in women with endometriosis
Rafi, J., Pathiraja, P. D. M., Gelson, E., Brown, R. N., & Alleemudder, D. I. (2022) · The Obstetrician & Gynaecologist · doi:10.1111/tog.12831 · Cited by 7
A 41-Year-Old Woman with Spontaneous Hemoperitoneum in Pregnancy at 28 Weeks
Kato, M., Miyazaki, Y., Kawamura, H., Orisaka, M., Kurokawa, T., & Yoshida, Y. (2023) · American Journal of Case Reports · doi:10.12659/ajcr.939330 · Cited by 6
“Junctional zone thickening in adenomyosis is believed to cause placental hypoplasia, leading to late miscarriage, preterm delivery, fetal growth restriction, and preeclampsia [15].”
BackgroundLin, M., Chen, Y., Xia, S., He, Z., Yu, X., Huang, L., Lin, S., Liang, B., Huang, Z., Mei, S.-Q., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1128082 · Cited by 6
Early pregnancy imaging predicts ischemic placental disease
Lee, B., Janzen, C., Aliabadi, A., Lei, M. Y. Y., Wu, H. H., Liu, D., Vangala, S. S., Devaskar, S. U., & Sung, K. (2023) · Placenta · doi:10.1016/j.placenta.2023.07.297 · Cited by 6
Karaca, E., Ercan, C. C., Akdemir, C., Sivrikoz, T. S., Salmaslıoğlu, A., Verit, F. F., Gürdöl, F., & Ömer, B. (2023) · Angiology · doi:10.1177/00033197231183228 · Cited by 6
Chatzakis, C., Eleftheriades, M. I., Demertzidou, E., Eleftheriades, A., Koletsos, N., LAVASIDIS, L. G., Zikopoulos, A., Dinas, K. D., & Sotiriadis, A. (2023) · Biomedicines · doi:10.3390/biomedicines11123106 · Cited by 6
“This transformation is essential to ensuring a sufficient blood supply to the developing fetus [3,4].”
BackgroundDoria-Borrell, P., & Pérez-García, V. (2024) · Communications Biology · doi:10.1038/s42003-024-06689-2 · Cited by 6
Placental deposition of C-reactive protein is a common feature of human pregnancy
Kim, E. N., Yoon, B. H., Jeon, E. J., Lee, J., Hong, J.-S., Lee, J., Hwang, D., Kim, K. C., Kim, J.-S., & Kim, C. J. (2015) · Placenta · doi:10.1016/j.placenta.2015.03.006 · Cited by 6
Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia
Bujold, E. (2015) · Evidence-Based Nursing · doi:10.1136/ebnurs-2014-101915 · Cited by 6
THROMBOPHILIAS IN OBSTETRICIAN AND GYNECOLOGICAL PRACTICE, HEPARIN PREVENTION
Momot, A. P., & Nikolaeva, M. G. (2017) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2017-13-71-78 · Cited by 6
Boutin, A., Dembickaja, R., Campanero, M., Nicolaides, K. H., & Demers, S. (2018) · American Journal of Perinatology · doi:10.1055/s-0038-1632369 · Cited by 6
Maternal serum TXNDC5 levels and thiol/disulfide homeostasis in preeclamptic pregnancies
Kaya, B., Turhan, U., Sezer, S., Bestel, A., Okumuş, Z. G., Dağ, İ., & Erel, Ö. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1557140 · Cited by 6
Cytotoxic effects of Shiga toxin-2 on human extravillous trophoblast cell lines
Scalise, M. L., Amaral, M. M., Reppetti, J., Damiano, A. E., Ibarra, C., & Sacerdoti, F. (2019) · Reproduction · doi:10.1530/rep-18-0581 · Cited by 6
Possibilities for prediction of preeclampsia complications (a review)
Navolotskaya, V. K., Lyashko, E. S., Shifman, E. M., Владимировна, К. О., Kulikov, A. V., Arustamyan, R. R., & Pylaeva, N. Y. (2019) · Russian Journal of Human Reproduction · doi:10.17116/repro20192501187 · Cited by 6
Gleason, R. L., & Sedaghati, F. (2022) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-021-01555-0 · Cited by 6
The Role of the Coagulation System in Preterm Parturition
Klaitman, V., Wiesel, R. B., Rafaeli, T., Mazor, M., & Erez, O. (2013) · InTech eBooks · doi:10.5772/54843 · Cited by 6
Akbaş, M., Koyuncu, F. M., Ülkümen, B. A., & Akbas, G. (2020) · Journal of Perinatal Medicine · doi:10.1515/jpm-2020-0464 · Cited by 6
Pala, A., D’Elia, P., Spampinato, G., Pittaluga, E., & Benagiano, G. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.629258 · Cited by 6
Anto, E. O., Boadu, W. I. O., Gyamfi, L. K., Korsah, E. E., Ansah, E., Frimpong, J., Tamakloe, V. C. K. T., Tawiah, A., Aboagye, E., Etwi‐Mensah, A., et al. (2024) · Public Health Challenges · doi:10.1002/puh2.154 · Cited by 5
“The underlying pathophysiology of preeclampsia has been proposed to be a result of an abnormal trophoblastic invasion during placental implantation, leading to placenta ischemia and insufficiency, with subsequent endothelial injury [7–9].”
Liu, X., Xin, S., Xu, F., Zhou, M., Ying, X., Zeng, Y., Zeng, X., & Zou, Y. (2024) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2024.2361278 · Cited by 5
“Defects in the human placenta during early pregnancy can result in miscarriage and complications in late pregnancy, such as preeclampsia, intrauterine growth restriction, and placenta accreta, which can affect the long-term health of both the fetus and its mother [17,18].”
Pattamathamakul, S., Duangkum, C., Chaiyarach, S., Kongwattanakul, K., Saksiriwuttho, P., Komwilaisak, R., Chantanavilai, S., Pongsamakthai, M., & Sirikarn, P. (2024) · Journal of Pregnancy · doi:10.1155/2024/9968509 · Cited by 5
“Consequently, this reduction in villous volume and surface area results in chronic fetal hypoxia and stress [9, 12 – 14].”
BackgroundEvaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy
Li, W., Zhang, S., Ye, S., Fang, X., Yu, X., Wang, X., Ma, Y., & Wang, Y.-L. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf108 · Cited by 5
“SAR is a critical placentation event essential for safeguarding maternal and fetal health, as impaired SAR is strongly associated with severe obstetric complications such as early pregnancy loss, preeclampsia, and fetal growth restriction [6].”
Ohtani, T., Ichinose, M., Ariyoshi, Y., Irie, M., Toshimitsu, M., Sayama, S., Seyama, T., Muto, H., Shitara, Y., Ito, A., et al. (2025) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.70075 · Cited by 5
“32,33 Although the overall frequency of HDP did not significantly differ between the groups in this study, six of seven (86”
Large-Scale Proteomics Reveals New Candidate Biomarkers for Late-Onset Preeclampsia
Andresen, I. J., Romero, R. J., Westerberg, A. C., Than, N. G., Gomez‐Lopez, N., Bhatti, G., Ahmodu, O., Gudicha, D. W., Meyyazhagan, A., Awonuga, A. O., et al. (2025) · Hypertension · doi:10.1161/hypertensionaha.125.25189 · Cited by 6
Self-citationThe Etiopathogenesis of Preeclampsia: Where Do We Stand Now?
Laskowska, M., Bednarek, A., & Stworowski, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14227992 · Cited by 5
“This results in the extensive remodeling of the maternal spiral arterioles into low-resistance, high-capacity, high-flow vessels [5,30,32,33].”
Zhu, X., Jiang, Y., Wang, L., Jiang, P., Zhong, Z., Li, H., Zheng, C., Chen, L., Wei, J., Lin, X., et al. (2025) · Physiological Genomics · doi:10.1152/physiolgenomics.00185.2025 · Cited by 5
Park, I. Y., Wie, J. H., Park, J. H., & Kwon, J. Y. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14781 · Cited by 5
“The disturbance of this initial process leads to inadequate coordination of vascular and inflammatory processes between mother and fetus, which can cause SGA pregnancy, preterm delivery, and a hypertensive disorder as various other factors are added during pregnancy.(19) This prospective study explored whether first t…”
BackgroundInfluentialGeneration of Knockout Mouse Trophoblast Stem Cells by CRISPR/Cas9
Doria-Borrell, P., Moya-Navamuel, M., Hemberger, M., & Pérez-García, V. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3746-3_8 · Cited by 5
Ip, P. N. P., Nguyen‐Hoang, L., Chaemsaithong, P., Guo, J., Wang, X., Sahota, D. S., Chung, J. P. W., & Poon, L. C. (2024) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2023.09.023 · Cited by 7
Liu, J., Li, W., Wang, J., Bai, L., Xu, J., Chen, X., Wang, S., Li, L., & Xu, X. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae118 · Cited by 5
“Many studies had showed that shallow EVTs invasion into the decidua accompanied by the insufficient remodeling of uterine spiral artery in patients with preeclampsia, which has been suggested to be major contributing factors of preeclampsia [12, 13].”
Establishment of human trophoblast stem cells from term smooth chorion
Hoshiyama, T., Muto, M., Matsumoto, S., Okamura, E., Jargalsaikhan, B.-E., Murakami, T., Tsuji, S., & Ema, M. (2025) · Placenta · doi:10.1016/j.placenta.2025.07.090 · Cited by 5
Live birth after uterine transplantation remains challenging
Donnez, J. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.1988 · Cited by 5
An efficient and combined placental T1‐ADC acquisition in pregnancies with and without pre‐eclampsia
Hutter, J. M., Ho, A., Jackson, L. H., Slator, P. J., Chappell, L. C., Hajnal, J. V., & Rutherford, M. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28809 · Cited by 5
“The mean results from the healthy cohort for the combined ADC-T 1 fit (Equation 2), displayed in Figure 5A,B show a downward trend over gestation for both T 1 (slope −11.3, P .”
BackgroundMethodInfluentialNeurologic Sequelae Associated with Hypertensive Disorders of Pregnancy
Scher, M. S. (2021) · Children · doi:10.3390/children8110945 · Cited by 5
Maternal Vascular Malperfusion and Associated Maternal Diseases
Dahlstrom, J. E., Subramaniam, A., & Faye-Petersen, O. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_19 · Cited by 6
Gusar, V. A., Timofeeva, A. V., Chagovets, V., Кан, Н. Е., Vysokikh, M. Y., Marey, M. V., Овиковна, К. А., Baev, B. O. R., & Sukhikh, G. T. (2022) · Life · doi:10.3390/life12010101 · Cited by 7
Decidual Natural Killer Cells Are Essential for a Successful Pregnancy (Review)
Elagab, E. A. M., Alshahrani, M. S., Elbadawi, A. A. A., Aedh, A. I., Osman, A. M., & Osman, H. M. (2022) · Advances in Reproductive Sciences · doi:10.4236/arsci.2022.103008 · Cited by 6
Short communication: Is there any benefit of initiating aspirin before the 11th week of gestation?
Ghesquière, L., Vachon‐Marceau, C., Kingdom, J. C., Ferreira, E., Côté, S., Guerby, P., Maheux‐Lacroix, S., & Bujold, E. (2022) · Pregnancy Hypertension · doi:10.1016/j.preghy.2022.10.009 · Cited by 5
Deep-learning based segmentation of the placenta and uterine cavity on prenatal MR images
Huang, J., Do, Q. N., Shahedi, M., Xi, Y., Lewis, M. A., Herrera, C. L., Owen, D. M., Spong, C. Y., Madhuranthakam, A. J., Twickler, D. M., et al. (2023) · SPIE Medical Imaging: Computer-Aided Diagnosis · doi:10.1117/12.2653659 · Cited by 5
“Abnormal placenta growth and development results in adverse pregnancy complications, such as preeclampsia, fetal growth restriction, and stillbirth [3].”
BackgroundComprehensive Review of Hypertensive Disorders Related to Pregnancy
Bangi, E. F., Yousuf, M. H., Upadhyay, S., Jain, P., & Jain, R. (2023) · Southern Medical Journal · doi:10.14423/smj.0000000000001571 · Cited by 5
de Vos, E. S., van der Meeren, L. E., Koning, A. H. J., Nikkels, P. G. J., Steegers, E. A. P., Steegers‐Theunissen, R. P. M., & Mulders, A. G. M. G. J. (2024) · Placenta · doi:10.1016/j.placenta.2024.01.019 · Cited by 6
Hinchliffe, E., & Heazell, A. E. P. (2025) · Journal of Chromatography B · doi:10.1016/j.jchromb.2025.124541 · Cited by 5
Can prenatal screening reduce the adverse obstetric outcomes related to abnormal placentation?
Ghidini, A., & Gratacós, E. (2014) · Prenatal Diagnosis · doi:10.1002/pd.4423 · Cited by 5
PP13, Decidual Zones of Necrosis, and Spiral Artery Remodeling—Preeclampsia Revisited?
Than, N. G. (2012) · Reproductive Sciences · doi:10.1177/1933719111431678 · Cited by 5
Metadata
- Authors
- Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R.
- Affiliations
- Leuven Institute for Fertility and Embryology (BE)
- Universitair Ziekenhuis Leuven (BE)
- National Institutes of Health (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 204
- Issue
- 3
- Pages
- 193-201
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3369813
- OpenAlex
- W2034492080
- Cited by
- 1,568
- References
- 82
- Citations by year
- 2026: 123 · 2025: 126 · 2024: 128 · 2023: 147 · 2022: 153 · 2021: 155 · 2020: 145 · 2019: 121 · 2018: 91 · 2017: 79 · 2016: 61 · 2015: 69 · 2014: 66 · 2013: 49 · 2012: 30
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Institutes of Health
- U.S. Department of Health and Human Services
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- great obstetrical syndromes, preeclampsia, fetal growth restriction, preterm labor, preterm premature rupture of membranes, miscarriage, placental abruption, spiral artery remodeling, placental biopsy
- MeSH terms
- Biopsy, Female, Humans, Placenta, Placenta Diseases, Pregnancy, Pregnancy Complications, Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
