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The “Great Obstetrical Syndromes” are associated with disorders of deep placentation
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Defective deep placentation has been associated with a spectrum of complications of pregnancy including preeclampsia, intrauterine growth restriction, preterm labor, preterm premature rupture of membranes, late spontaneous abortion, and abruptio placentae. The disease of the placental vascular bed that underpins these complications is commonly investigated with targeted biopsies. In this review, we critically evaluate the biopsy technique to summarize the salient types of defective deep placentation, and propose criteria for the classification of defective deep placentation into 3 types based on the degree of restriction of remodeling and the presence of obstructive lesions in the myometrial segment of the spiral arteries.
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“Inadequate placentation is seen in several common obstetrical syn dromes, including fetal growth restriction, spontaneous second trimester miscarriages, placental abruption, preterm birth, and hyper tensive disorders in pregnancy (Brosens et al., 2011).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Brosens et al., 2011
In the citing paper
“Failure of trophoblast invasion and arterial remodeling is associated with the 'Great Obstetrical Syndromes', including growth restriction, pre-eclampsia and late spontaneous abortion, due to impaired maternal perfusion (64).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [64]
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BackgroundNeutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss
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Preeclampsia: a link between trophoblast dysregulation and an antiangiogenic state
Romero, R. J., & Chaiworapongsa, T. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70431 · Cited by 143
Self-citationEmerging role for dysregulated decidualization in the genesis of preeclampsia
Conrad, K. P., Rabaglino, M. B., & Uiterweer, E. D. P. (2017) · Placenta · doi:10.1016/j.placenta.2017.06.005 · Cited by 146
Colson, A., Sonveaux, P., Debiève, F., & Sferruzzi-Perri, A. N. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa053 · Cited by 149
Huang, Z., Du, G., Huang, X., Li, H., Han, X., Xu, B., Zhang, Y., Yu, M., Qin, Y., Xia, Y., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.015 · Cited by 141
“The failure of transitions from progenitors to different trophoblast cells or compromised trophoblast function will cause significant adverse pregnancy outcomes, including URPL [24].”
BackgroundGenomic imprinting in the human placenta
Monk, D. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.06.032 · Cited by 147
Endometriosis increases the risk of obstetrical and neonatal complications
Berlac, J. F., Hartwell, D., Skovlund, C. W., Langhoff‐Roos, J., & Lidegaard, Ø. (2017) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13111 · Cited by 139
Redline, R. W., Roberts, D. J., Parast, M. M., Ernst, L. M., Morgan, T. K., Greene, M. F., Gyamfi‐Bannerman, C., Louis, J. M., Maltepe, E., Mestan, K. K. L., et al. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.08.010 · Cited by 148
Self-citationChaiworapongsa, T., Romero, R. J., Savasan, Z. A., Kusanovic, J. P., Oggè, G., Soto, E., Dong, Z., Tarca, A. L., Bhatti, G., & Hassan, S. S. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.589932 · Cited by 139
Self-citationWNT and NOTCH signaling in human trophoblast development and differentiation
Dietrich, B., Haider, S., Meinhardt, G., Pollheimer, J., & Knöfler, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04285-3 · Cited by 141
The cytotrophoblastic shell and complications of pregnancy
Burton, G. J., & Jauniaux, E. R. M. (2017) · Placenta · doi:10.1016/j.placenta.2017.06.007 · Cited by 138
Decidualization resistance in the origin of preeclampsia
Garrido‐Gómez, T., Castillo-Marco, N., Cordero, T., & Simón, C. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.09.039 · Cited by 136
The prediction of early preeclampsia: Results from a longitudinal proteomics study
Tarca, A. L., Romero, R. J., Benshalom-Tirosh, N., Than, N. G., Gudicha, D. W., Done, B., Pacora, P., Chaiworapongsa, T., Panaitescu, B., Tirosh, D., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217273 · Cited by 133
Self-citationBrosens, I., Pijnenborg, R., & Benagiano, G. (2013) · Placenta · doi:10.1016/j.placenta.2012.11.017 · Cited by 135
Risks of adverse pregnancy outcome in endometriosis
Brosens, I., Brosens, J. J., Fusi, L., Al-Sabbagh, M., Kuroda, K., & Benagiano, G. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.02.024 · Cited by 132
Maternal Vascular Malperfusion and Adverse Perinatal Outcomes in Low-Risk Nulliparous Women
Wright, E., Audette, M. C., Ye, X. Y., Keating, S. J., Hoffman, B., Lye, S. J., Shah, P. S., & Kingdom, J. C. (2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002264 · Cited by 133
Biology and pathology of the uterine microenvironment and its natural killer cells
Wang, F., Qualls, A., Marques-Fernandez, L., & Colucci, F. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00739-z · Cited by 139
“Specifically, preeclampsia (PE), FGR, preterm labor, preterm premature rupture of membranes, recurrent spontaneous abortion (RSA), and abruption placentae are all GOS responsible for maternal and perinatal morbidity [121].”
BackgroundAnimal models of human pregnancy and placentation: alternatives to the mouse
Carter, A. M. (2020) · Reproduction · doi:10.1530/rep-20-0354 · Cited by 130
Roberge, S., Bujold, E., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.238 · Cited by 135
“(<100 and 100 mg) and the gestational age at the onset of therapy ( 16 and >16 I weeks of pregnancy is associated with increased risk of the subsequent development of preeclampsia, birth of smallfor-gestational-age neonates, and placental abruption.(1-6) Numerous randomized controlled trials have investigated the pote…”
Menon, R., Behnia, F., Polettini, J., & Richardson, L. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00808-x · Cited by 131
Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection
Jabrane‐Ferrat, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01397 · Cited by 130
“Flaws in EVT invasion and arteries’ remodeling can lead to placental dysfunction andmajor pregnancy disorders such as preeclampsia, fetal growth restriction (FGR) and recurrent miscarriage (30).”
BackgroundUterine natural killer cells: from foe to friend in reproduction
Díaz-Hernández, I., Alecsandru, D., García-Velasco, J. A., & Domı́nguez, F. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa062 · Cited by 136
Hyperemesis gravidarum and risks of placental dysfunction disorders: a population‐based cohort study
Bolin, M., Åkerud, H., Cnattingius, S., Stephansson, O., & Wikström, A. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12132 · Cited by 127
Tissue stiffness at the human maternal–fetal interface
Abbas, Y., Carnicer‐Lombarte, A., Gardner, L., Thomas, J. R., Brosens, J. J., Moffett, A., Sharkey, A., Franze, K., Burton, G. J., & Oyen, M. L. (2019) · Human Reproduction · doi:10.1093/humrep/dez139 · Cited by 127
“fetal growth restriction, and stillbirth (Brosens et al., 2011).”
Cindrova-Davies, T., Fogarty, N. M. E., Jones, C. J. P., Kingdom, J., & Burton, G. J. (2018) · Placenta · doi:10.1016/j.placenta.2018.06.307 · Cited by 127
Januar, V., Desoyé, G., Novakovic, B., Cvitic, S., & Saffery, R. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.07.011 · Cited by 127
Metadata
- Authors
- Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R.
- Affiliations
- Leuven Institute for Fertility and Embryology (BE)
- Universitair Ziekenhuis Leuven (BE)
- National Institutes of Health (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 204
- Issue
- 3
- Pages
- 193-201
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3369813
- OpenAlex
- W2034492080
- Cited by
- 1,568
- References
- 82
- Citations by year
- 2026: 123 · 2025: 126 · 2024: 128 · 2023: 147 · 2022: 153 · 2021: 155 · 2020: 145 · 2019: 121 · 2018: 91 · 2017: 79 · 2016: 61 · 2015: 69 · 2014: 66 · 2013: 49 · 2012: 30
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Institutes of Health
- U.S. Department of Health and Human Services
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- great obstetrical syndromes, preeclampsia, fetal growth restriction, preterm labor, preterm premature rupture of membranes, miscarriage, placental abruption, spiral artery remodeling, placental biopsy
- MeSH terms
- Biopsy, Female, Humans, Placenta, Placenta Diseases, Pregnancy, Pregnancy Complications, Syndrome
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