Cited by 1,568Pregnancy and preeclampsia studiesReproductive System and PregnancyMaternal and fetal healthcare

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The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

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Brosens, Ivo, Pijnenborg, Robert, Vercruysse, Lisbeth, Romero, Roberto·2011·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2010.08.009PMC PMC3369813

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Abstract

Defective deep placentation has been associated with a spectrum of complications of pregnancy including preeclampsia, intrauterine growth restriction, preterm labor, preterm premature rupture of membranes, late spontaneous abortion, and abruptio placentae. The disease of the placental vascular bed that underpins these complications is commonly investigated with targeted biopsies. In this review, we critically evaluate the biopsy technique to summarize the salient types of defective deep placentation, and propose criteria for the classification of defective deep placentation into 3 types based on the degree of restriction of remodeling and the presence of obstructive lesions in the myometrial segment of the spiral arteries.

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Deep trophoblast invasion and spiral artery remodeling
Pijnenborg, R., & Brosens, I. A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511750847.012 · Cited by 14
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Fetal death: A condition with a dissociation in the concentrations of soluble vascular endothelial growth factor receptor-2 between the maternal and fetal compartments
Chaiworapongsa, T., Kusanovic, J. P., Savasan, Z. A., Mazaki‐Tovi, S., Kim, S. K., Vaisbuch, E., Tarca, A. L., Mittal, P., Oggè, G., Madan, I., et al. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050903410664 · Cited by 12
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[Spiral arterioles in the decidua basalis in hypertensive complications of pregnancy].
Renaer, M., & Brosens, I. A. (1963) · PubMed · Cited by 11
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Placental vascular remodelling
King, A., & Loke, Y. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62389-6 · Cited by 7
Relative contribution of interstitial and endovascular trophoblast to elastica breakdown in placental bed spiral arteries
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Self-citation

Research works printed but not linked: 2

Brosens, 1972, The role of the spiral arteries in the pathogenesis of preeclampsia, Obstet Gynecol Annu, 1, 177
Robson, 2001, Endovascular trophoblast invasion and spiral artery transformation: the ”two wave” theory revisited, Placenta, 22, A25

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“Obstructive lesions in the myometrial segment of spiral bed arteries have been found in 70% of the FGR cases associated with preeclampsia.(46) Noninfectious villitis, also called villitis of unknown etiology (VUE), has been described as a pattern of placental injury occurring predominantly in”
BackgroundInfluential
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Self-citation

See all 1,568

Authors: Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R.
Affiliations: Leuven Institute for Fertility and Embryology (BE)
Universitair Ziekenhuis Leuven (BE)
National Institutes of Health (US)
ORCID: Brosens, Ivo
Pijnenborg, Robert
Romero, Roberto
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2011-03
Volume: 204
Issue: 3
Pages: 193-201
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2010.08.009
PMC: PMC3369813
OpenAlex: W2034492080
Cited by: 1,568
References: 82
Citations by year: 2026: 123 · 2025: 126 · 2024: 128 · 2023: 147 · 2022: 153 · 2021: 155 · 2020: 145 · 2019: 121 · 2018: 91 · 2017: 79 · 2016: 61 · 2015: 69 · 2014: 66 · 2013: 49 · 2012: 30
FWCI: 4.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
U.S. Department of Health and Human Services
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
Keywords: great obstetrical syndromes, preeclampsia, fetal growth restriction, preterm labor, preterm premature rupture of membranes, miscarriage, placental abruption, spiral artery remodeling, placental biopsy
MeSH terms: Biopsy, Female, Humans, Placenta, Placenta Diseases, Pregnancy, Pregnancy Complications, Syndrome

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The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

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