Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers
Abstract
Objective Obese women are at increased risk to deliver a large infant, however, the underlying mechanisms are poorly understood. Fetal glucose availability is critically dependent on placental transfer and is linked to fetal growth by regulating the release of fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and insulin levels and (2) placental glucose transporter (GLUT) expression and activity are positively correlated with early pregnancy maternal body mass index and infant birthweight.Study design Subjects in this prospective observational cohort study were nondiabetic predominantly Hispanic women delivered at term. Fasting maternal and umbilical vein glucose and insulin concentrations were determined in 29 women with varying early pregnancy body mass index (range, 18.0-54.3) who delivered infants with birthweights ranging from 2800-4402 g. We isolated syncytiotrophoblast microvillous and basal plasma membranes from 33 placentas and determined the expression of GLUT-1 and -9 (Western blot) and glucose uptake (radiolabeled glucose).Results Birthweight was positively correlated with umbilical vein glucose and insulin and maternal body mass index. Umbilical vein glucose levels were positively correlated with placental weight and maternal body mass index, but not with maternal fasting glucose. Basal plasma membranes GLUT-1 expression was positively correlated with birthweight. In contrast, syncytiotrophoblast microvillous GLUT-1 and -9, basal plasma membranes GLUT-9 expression and syncytiotrophoblast microvillous and basal plasma membranes glucose transport activity were not correlated with birthweight.Conclusion Because maternal fasting glucose levels and placental glucose transport capacity were not increased in obese women delivering larger infants, we speculate that increased placental size promotes glucose delivery to these fetuses.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In obese women delivering larger infants, placental GLUT1 expression and System A activity are higher in the basal and microvillous membranes, respectively, than in women with a lean BMI.
“By contrast, in obese women delivering larger infants, placental GLUT1 expression and System A activity are higher in the basal and microvillous membranes, respectively, than seen in women with a lean BMI (1,279).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [1]
Cites
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563 · see citing works
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303 · see citing works
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667 · see citing works
Catalano, P., & Ehrenberg, H. M. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00989.x · Cited by 828 · see citing works
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712 · see citing works
Fetuses of obese mothers develop insulin resistance in utero
Catalano, P. M., Presley, L., Minium, J., & Hauguel-de Mouzon, S. (2009) · Diabetes Care · doi:10.2337/dc08-2077 · Cited by 655 · see citing works
WEIGHT AND LENGTH AT BIRTH OF INFANTS OF DIABETIC MOTHERS
Pedersen, J. (1954) · European Journal of Endocrinology · doi:10.1530/acta.0.0160330 · Cited by 495 · see citing works
Management of Obesity in Pregnancy
Catalano, P. M. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000253311.44696.85 · Cited by 373 · see citing works
Jansson, T., Wennergren, M., & Illsley, N. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263141 · Cited by 320 · see citing works
Self-citationIdentification and Characterization of Human Glucose Transporter-like Protein-9 (GLUT9)
Augustin, R., Carayannopoulos, M. O., Dowd, L. O., Phay, J. E., Moley, J. F., & Moley, K. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312226200 · Cited by 284 · see citing works
Placental structure and inflammation in pregnancies associated with obesity
Roberts, K., Riley, S. C., Reynolds, R. M., Barr, S., Evans, M., Statham, A., Hor, K., Jabbour, H. N., Norman, J. E., & Denison, F. C. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.023 · Cited by 281 · see citing works
Jansson, T., Ylvén, K., Wennergren, M., & Powell, T. L. (2002) · Placenta · doi:10.1053/plac.2002.0826 · Cited by 218 · see citing works
Self-citationPlacental glucose transport and GLUT 1 expression in insulin-dependent diabetes
Jansson, T., Wennergren, M., & Powell, T. L. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70169-9 · Cited by 166 · see citing works
Self-citationShould we always choose a nonparametric test when comparing two apparently nonnormal distributions?
Skovlund, E., & Fenstad, G. U. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00264-x · Cited by 163 · see citing works
Gaither, K., Quraishi, A. N., & Illsley, N. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5438 · Cited by 149 · see citing works
Simultaneous preparation of paired, syncytial, microvillous and basal membranes from human placenta
Illsley, N. P., Wang, Z.-Q., Gray, A., Sellers, M. C., & Jacobs, M. M. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90157-j · Cited by 140 · see citing works
Localisation of proteins of iron metabolism in the human placenta and liver
Bastin, J. M., Drakesmith, H., REES, M. C. P., Sargent, I. L., & Townsend, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06216.x · Cited by 130 · see citing works
Protein Nitration in Placenta – Functional Significance
Webster, R. P., Roberts, V. H. J., & Myatt, L. (2008) · Placenta · doi:10.1016/j.placenta.2008.09.003 · Cited by 114 · see citing works
Localization of erythrocyte/HepG2-type glucose transporter (GLUT1) in human placental villi
Takata, K., Kasahara, T., Kasahara, M., Ezaki, O., & Hirano, H. (1992) · Cell and Tissue Research · doi:10.1007/bf00319362 · Cited by 109 · see citing works
Birth weight for gestational age of Mexican American infants born in the United States
Overpeck, M. D. (1999) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(98)00553-5 · Cited by 91 · see citing works
Maternal BMI, glucose tolerance, and adverse pregnancy outcomes
Stuebe, A., Landon, M., Lai, Y., Spong, C., Carpenter, M., Ramin, S., Casey, B., Wapner, R., Varner, M., Rouse, D., et al. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.04.035 · Cited by 81 · see citing works
Transepithelial Glucose Transport and Metabolism in BeWo Choriocarcinoma Cells
Vardhana, P. A., & Illsley, N. P. (2002) · Placenta · doi:10.1053/plac.2002.0857 · Cited by 78 · see citing works
Glucose transport across the basal plasma membrane of human placental syncytiotrophoblast
Johnson, L. W., & Smith, C. H. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90472-9 · Cited by 77 · see citing works
Stability of reference proteins in human placenta: General protein stains are the benchmark
Lanoix, D., St‐Pierre, J., Lacasse, A., Viau, M., Lafond, J., & Vaillancourt, C. (2012) · Placenta · doi:10.1016/j.placenta.2011.12.008 · Cited by 74 · see citing works
Bradley, J. L., Leibold, E. A., Harris, Z. L., Wobken, J. D., Clarke, S. L., Zumbrennen‐Bullough, K. B., Eisenstein, R. S., & Georgieff, M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00525.2003 · Cited by 74 · see citing works
Dennedy, M. C., Avalos, G., O’Reilly, M., O'Sullivan, E. P., Gaffney, G., & Dunne, F. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2674 · Cited by 63 · see citing works
Mouzon, S. H., Challier, J.-C., Cedard, L., & Olivé, G. (1983) · Pediatric Research · doi:10.1203/00006450-198309000-00009 · Cited by 62 · see citing works
Bibee, K., Illsley, N. P., & Moley, K. H. (2010) · Reproductive Sciences · doi:10.1177/1933719110380276 · Cited by 53 · see citing works
Increase in normal placental weights related to increase in maternal body mass index
Swanson, L. D., Bewtra, C., Swanson, L. D., & Bewtra, C. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701866963 · Cited by 52 · see citing works
Asymmetrical Transport of Glucose Across the In Vitro Perfused Human Placenta
Schneider, H., Reiber, W., Sager, R., & Malek, A. (2002) · Placenta · doi:10.1053/plac.2002.0869 · Cited by 48 · see citing works
The association of maternal and fetal glucose homeostasis with fetal adiposity and birthweight
Walsh, J., Mahony, R., Byrne, J., Foley, M., & McAuliffe, F. M. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.09.022 · Cited by 47 · see citing works
Desforges, M., Ditchfield, A., Hirst, C., Pegorie, C., Martyn-Smith, K., Sibley, C. P., & Greenwood, S. L. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6093-0_9 · Cited by 43 · see citing works
Glucose Production by the Human Placenta in Vivo
Prendergast, C. H., Parker, K. H., Gray, R., Venkatesan, S., Bannister, P. A., Castro-Soares, J., Murphy, K. W., Beard, R. W., Regan, L., Robinson, S., et al. (1999) · Placenta · doi:10.1053/plac.1999.0419 · Cited by 26 · see citing works
Glucose transport from mother to fetus—A theoretical study
Barta, E., & Drugan, A. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.12.010 · Cited by 25 · see citing works
Flagged first, then by citations
2 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Influence of Maternal Obesity on the Long-Term Health of Offspring
Godfrey, K. M., Reynolds, R. M., Prescott, S. L., Nyirenda, M., Jaddoe, V. W. V., Eriksson, J. G., & Broekman, B. F. P. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30107-3 · Cited by 1,059 · see citing works
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 483 · see citing works
Self-citationEffects of maternal obesity on placental function and fetal development
Howell, K. R., & Powell, T. L. (2016) · Reproduction · doi:10.1530/rep-16-0495 · Cited by 354 · see citing works
Self-citationPlacental Function in Maternal Obesity
Kelly, A. C., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20190266 · Cited by 227 · see citing works
Self-citationMetabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Xie, S., Xu, S., Deng, W., & Tang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01378-8 · Cited by 185 · see citing works
Aye, I. L. M. H., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515484112 · Cited by 163 · see citing works
Self-citationMaternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring
Helle, E., & Priest, J. R. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.011541 · Cited by 151 · see citing works
Natale, B. V., Gustin, K., Lee, K., Holloway, A. C., Laviolette, S. R., Natale, D. R. C., & Hardy, D. B. (2020) · Scientific Reports · doi:10.1038/s41598-019-57318-6 · Cited by 125 · see citing works
Berntsen, S., & Pinborg, A. B. (2018) · Birth Defects Research · doi:10.1002/bdr2.1219 · Cited by 116 · see citing works
Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction
Dumolt, J. H., Powell, T. L., & Jansson, T. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2021.02.001 · Cited by 106 · see citing works
Self-citationMaternal-fetal cross-talk via the placenta: influence on offspring development and metabolism
Kramer, A. C., Jansson, T., Bale, T. L., & Powell, T. L. (2023) · Development · doi:10.1242/dev.202088 · Cited by 110 · see citing works
Self-citationReview: Placental transport and metabolism of energy substrates in maternal obesity and diabetes
Gallo, L. A., Barrett, H. L., & Nitert, M. D. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.006 · Cited by 88 · see citing works
Son, J. S., Liu, X., Tian, Q., Zhao, L., Chen, Y., Hu, Y., Chae, S. A., de Avila, J. M., Zhu, M. J., & Du, . (2019) · The Journal of Physiology · doi:10.1113/jp277698 · Cited by 86 · see citing works
Gaccioli, F., Aye, I. L. M. H., Roos, S., Lager, S., Ramirez, V. I., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0054-8 · Cited by 85 · see citing works
Self-citationShi, Y., Zhang, Y., Ran, F., Liu, J., Lin, J., Hao, X., Ding, L., & Ye, Q. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.09.012 · Cited by 83 · see citing works
Panchenko, P. E., Voisin, S. A. C., Jouin, M., Jouneau, L., Prézelin, A., Lecoutre, S., Breton, C., Jammes, H., Junien, C., & Gabory, A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0188-3 · Cited by 77 · see citing works
Lager, S., Ramirez, V. I., Gaccioli, F., Jang, B., Jansson, T., & Powell, T. L. (2016) · Placenta · doi:10.1016/j.placenta.2016.02.010 · Cited by 78 · see citing works
Self-citationStanirowski, P. J., Szukiewicz, D., Pyźlak, M., Abdalla, N., Sawicki, W., & Cendrowski, K. (2016) · Endocrine · doi:10.1007/s12020-016-1202-4 · Cited by 75 · see citing works
Wu, Y., Wang, F., Reece, E. A., & Yang, P. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.01.017 · Cited by 74 · see citing works
Michelsen, T. M., Holme, A. M., Holm, M. B., Roland, M. C. P., Haugen, G. N., Powell, T. L., Jansson, T., & Henriksen, T. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01154 · Cited by 74 · see citing works
Self-citationChassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 66 · see citing works
Self-citationArroyo‐Jousse, V., Jaramillo, A., Castaño‐Moreno, E., Lépez, M., Carrasco‐Negüe, K., & Casanello, P. C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165558 · Cited by 68 · see citing works
Bedell, S., Hutson, J. R., de Vrijer, B., & Eastabrook, G. D. M. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200616144512 · Cited by 94 · see citing works
Moreno-Sepulveda, J. A., Espinós, J. J., & Checa, M. Á. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.03.002 · Cited by 61 · see citing works
Melnik, B. C., John, S. M., & Schmitz, G. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-014-0377-9 · Cited by 56 · see citing works
James‐Allan, L. B., Arbet, J., Teal, S. B., Powell, T. L., & Jansson, T. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02778 · Cited by 55 · see citing works
Self-citationZhong, J., Reece, E. A., & Yang, P. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.024 · Cited by 52 · see citing works
RetractedWankhade, U. D., Thakali, K. M., & Shankar, K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.001 · Cited by 48 · see citing works
Nogues, P., Santos, E. D., Couturier-Tarrade, A., Berveiller, P., Arnould, L., Lamy, E., Grassin-Delyle, S., Vialard, F., & Dieudonné, M. (2020) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/clinem/dgaa660 · Cited by 42 · see citing works
Stanirowski, P. J., Szukiewicz, D., Pazura, M., Sawicki, W., & Cendrowski, K. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.04.008 · Cited by 45 · see citing works
Vaughan, O. R., Rosario, F. J., Chan, J., Cox, L. A., Ferchaud‐Roucher, V., Berry, K. A. Z., Reusch, J. E. B., Keller, A. C., Powell, T. L., & Jansson, T. (2022) · The Journal of Physiology · doi:10.1113/jp282462 · Cited by 44 · see citing works
Self-citationChen, Y. H., Li, L., Chen, W., Liu, Z. B., Ma, L., Gao, X., He, J. L., Wang, H., Zhao, M., Yang, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52018-7 · Cited by 43 · see citing works
Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming
Sureshchandra, S., Marshall, N., & Messaoudi, I. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0619-181r · Cited by 38 · see citing works
Lager, S., Ramirez, V. I., Acosta, O. M., Meireles, C. L., Miller, E., Gaccioli, F., Rosario, F. J., Gelfond, J. A. L., Hakala, K. W., Weintraub, S. T., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01384 · Cited by 39 · see citing works
Self-citationJohns, E. C., Denison, F. C., & Reynolds, R. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.025 · Cited by 41 · see citing works
Fetomaternal Expression of Glucose Transporters (GLUTs)—Biochemical, Cellular and Clinical Aspects
Sibiak, R., Ożegowska, K., Wender-Ożegowska, E., Gutaj, P., Mozdziak, P. E., & Kempisty, B. (2022) · Nutrients · doi:10.3390/nu14102025 · Cited by 40 · see citing works
Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters
Basak, S., Varma, S., & Duttaroy, A. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215353 · Cited by 39 · see citing works
Role of Placental Glucose Transporters in Determining Fetal Growth
Joshi, N. P., Mane, A. R., Sahay, A. S., Sundrani, D. P., Joshi, S., & Yajnik, C. S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00699-9 · Cited by 38 · see citing works
Korošec, S., Frangež, H. B., Steblovnik, L., Verdenik, I., & Bokal, E. V. (2015) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-015-0601-4 · Cited by 37 · see citing works
Paulsen, M. E., Rosario, F. J., Wesolowski, S. R., Powell, T. L., & Jansson, T. (2018) · The FASEB Journal · doi:10.1096/fj.201801015r · Cited by 35 · see citing works
Self-citationVaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0374-4 · Cited by 32 · see citing works
Self-citationStanirowski, P. J., Szukiewicz, D., Pyźlak, M., Abdalla, N., Sawicki, W., & Cendrowski, K. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1387897 · Cited by 32 · see citing works
HTLV-1 targets human placental trophoblasts in seropositive pregnant women
Tezuka, K., Fuchi, N., Okuma, K., Tsukiyama, T., Miura, S., Hasegawa, Y., Nagata, A., Komatsu, N., Hasegawa, H., Sasaki, D., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135525 · Cited by 31 · see citing works
James‐Allan, L. B., Teal, S. B., Powell, T. L., & Jansson, T. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00173-y · Cited by 30 · see citing works
Self-citationMadlala, H. P., Malaba, T. R., Newell, M., & Myer, L. (2020) · Tropical Medicine & International Health · doi:10.1111/tmi.13387 · Cited by 29 · see citing works
Maternal High Linoleic Acid Alters Placental Fatty Acid Composition
Shrestha, N., Holland, O. J., Kent, N. L., Perkins, A. V., McAinch, A. J., Cuffe, J. S. M., & Hryciw, D. H. (2020) · Nutrients · doi:10.3390/nu12082183 · Cited by 28 · see citing works
Richardson, B. S., Ruttinger, S., Brown, H. K., Regnault, T. R. H., & de Vrijer, B. (2017) · Early Human Development · doi:10.1016/j.earlhumdev.2017.06.009 · Cited by 27 · see citing works
Brett, K., Ferraro, Z. M., Holčı́k, M., & Adamo, K. B. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1049522 · Cited by 26 · see citing works
Adibi, J. J., Layden, A. J., Birru, R. L., Miragaia, A. S., Xun, X., Smith, M. C., Yin, Q., Millenson, M. E., O’Connor, T. G., Barrett, E. S., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa063 · Cited by 26 · see citing works
Castillo‐Castrejón, M., Jansson, T., & Powell, T. L. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2019 · Cited by 25 · see citing works
Self-citationCastillo‐Castrejón, M., Yamaguchi, K., Rodel, R. L., Erickson, K., Kramer, A. W., Hirsch, N. M., Rolloff, K. P., Jansson, T., Barbour, L. A., & Powell, T. L. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111319 · Cited by 24 · see citing works
Self-citationStanirowski, P. J., Lipa, M., Bomba-Opon, D. A., & Wielgoś, M. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.12.003 · Cited by 24 · see citing works
Mazaki‐Tovi, S., Vaisbuch, E., Tarca, A. L., Kusanovic, J. P., Than, N. G., Chaiworapongsa, T., Dong, Z., Hassan, S. S., & Romero, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143779 · Cited by 23 · see citing works
Thakali, K. M., Zhong, Y., Cleves, M., Andres, A., & Shankar, K. (2020) · Placenta · doi:10.1016/j.placenta.2020.02.018 · Cited by 26 · see citing works
Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study
Kodesh, A., Levine, S. Z., Khachadourian, V., Rahman, R., Schlessinger, A., O’Reilly, P. F., Grove, J., Schendel, D., Buxbaum, J. D., Croen, L., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721001021 · Cited by 22 · see citing works
García-Santillán, J.-A., Lazo-de-la-Vega-Monroy, M.-L., Rodriguez-Saldaña, G.-C., Solís‐Barbosa, M. A., Corona-Figueroa, M.-A., Gónzalez-Domínguez, M.-I., Gomez-Zapata, H.-M., Malacara, J. M., & Barbosa‐Sabanero, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.822527 · Cited by 24 · see citing works
Stanirowski, P. J., Szukiewicz, D., Majewska, A., Wątroba, M., Pyźlak, M., Bomba-Opon, D. A., & Wielgoś, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245833 · Cited by 19 · see citing works
Acosta‐Manzano, P., Leopold‐Posch, B., Simmons, D. S., Devlieger, R., Galjaard, S., Corcoy, R., Adelantado, J. M., Dunne, F., Harreiter, J., Kautzky‐Willer, A., et al. (2021) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16945 · Cited by 18 · see citing works
Salmeri, N., Seidenari, A., Cavoretto, P. I., Papale, M., Candiani, M., & Farina, A. (2024) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27659 · Cited by 18 · see citing works
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb
Diniz, M. S., Grilo, L. F., Tocantins, C., Falcão‐Pires, I., & Pereira, S. P. (2023) · Metabolites · doi:10.3390/metabo13070845 · Cited by 17 · see citing works
Basak, S., Vilasagaram, S., Naidu, K., & Duttaroy, A. K. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3396-7 · Cited by 15 · see citing works
Zhao, S., Wang, D., Li, Z., Xu, S., Chen, H., Ding, W., Yang, J., Zhao, W., Sun, B., & Wang, Z. (2021) · Placenta · doi:10.1016/j.placenta.2021.07.286 · Cited by 15 · see citing works
Differential Effects of Post-Weaning Diet and Maternal Obesity on Mouse Liver and Brain Metabolomes
Safi-Stibler, S., Thévenot, E., Jouneau, L., Jouin, M., Seyer, A., Jammes, H., Rousseau‐Ralliard, D., Baly, C., & Gabory, A. (2020) · Nutrients · doi:10.3390/nu12061572 · Cited by 14 · see citing works
The early life exposome and autism risk: a role for the maternal microbiome?
Gesù, C. M. D., & Buffington, S. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2385117 · Cited by 16 · see citing works
Ermini, L., Nuzzo, A. M., Ietta, F., Romagnoli, R., Moretti, L., Masturzo, B., Paulesu, L. R., & Rolfo, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126625 · Cited by 14 · see citing works
Wang, S., Ning, J., Huai, J., & Yang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158572 · Cited by 13 · see citing works
Kappen, C., Krüger, C., Jones, S., Herion, N. J., & Salbaum, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224754 · Cited by 13 · see citing works
Chi, X., Feng, C., Wang, X., & Jin, Z. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14429 · Cited by 13 · see citing works
Mouse models of preeclampsia with preexisting comorbidities
Waker, C. A., Hwang, A. E., Bowman-Gibson, S., Chandiramani, C. H., Linkous, B., Stone, M. L., Keoni, C., Kaufman, M. R., & Brown, T. L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1137058 · Cited by 12 · see citing works
Silva, M. H. (2021) · Current Research in Toxicology · doi:10.1016/j.crtox.2021.08.002 · Cited by 12 · see citing works
Alrumaihi, F., Al-Doaiss, A. A., Ullah, F., Alwanian, W. M., Alharbi, H. O., Alassaf, F. S., Alfifi, S. M., Alshabrmi, F. M., Alkhayl, F. F. A., & Alatawi, E. A. (2025) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2025.103056 · Cited by 10 · see citing works
Hu, M., Zhang, X., Gao, Y.-P., Hu, Y., Teng, T., Wang, S., & Tang, Q. (2024) · Aging and Disease · doi:10.14336/ad.2024.0113 · Cited by 9 · see citing works
Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in Mice
Shrestha, M. M., Wermelin, S., Stener‐Victorin, E., Asterholm, I. W., & Benrick, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094939 · Cited by 9 · see citing works
Mazaki‐Tovi, S., Tarca, A. L., Vaisbuch, E., Kusanovic, J. P., Than, N. G., Chaiworapongsa, T., Dong, Z., Hassan, S. S., & Romero, R. J. (2016) · Journal of Perinatal Medicine · doi:10.1515/jpm-2015-0259 · Cited by 8 · see citing works
Synthesis of phospholipids in human placenta
Powell, T. L., Ferchaud‐Roucher, V., Madi, L., Uhlson, C. L., Berry, K. A. Z., Kramer, A. C., Erickson, K., Palmer, C. E., Chassen, S. S., & Castillo‐Castrejón, M. (2024) · Placenta · doi:10.1016/j.placenta.2024.01.007 · Cited by 9 · see citing works
Self-citationThe impact of obesity on placental vascular development and function
Ramanlal, I., James, J. L., & Boss, A. L. (2026) · Molecular Human Reproduction · doi:10.1093/molehr/gaag002 · Cited by 7 · see citing works
Maternal obesity-related placental dysfunction: From peri-conception to late gestation
Amabebe, E., Ikumi, N. M., Pillay, K., Matjila, M. J., & Anumba, D. O. C. (2023) · Placenta and Reproductive Medicine · doi:10.54844/prm.2023.0361 · Cited by 6 · see citing works
Kakadia, J. H., Khalid, M. U., Heinemann, I. U., & Han, V. K. M. (2024) · Journal of Molecular Endocrinology · doi:10.1530/jme-23-0137 · Cited by 5 · see citing works
Maternal obesity attenuates PPARγ nuclear migration impairing offspring adipogenesis
de Sousa, É., & Rodrigues, A. C. (2023) · Journal of Molecular Endocrinology · doi:10.1530/jme-23-0050 · Cited by 5 · see citing works
Bayat, F. (2025) · EJNMMI Radiopharmacy and Chemistry · doi:10.1186/s41181-025-00346-7 · Cited by 4 · see citing works
Sibiak, R., Gutaj, P., Mantaj, U., Adamczak, Ł., Blatkiewicz, M., Ruciński, M., & Wender-Ożegowska, E. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14369 · Cited by 4 · see citing works
Ünek, G., Çetinkaya, B. D., Doğru, S., Dogum, K., Molbay, M., Özmen, A., Yanar, K., Kipmen‐Korgun, D., Köksoy, S., Sakıncı, M., et al. (2019) · Biologia · doi:10.2478/s11756-019-00350-8 · Cited by 3 · see citing works
Soliman, A. T., Hamed, N., Alyafei, F., Alaaraj, N., Ahmad, S., Itani, M., & Soliman, N. A. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.17.2.0222 · Cited by 2 · see citing works
Dong, Z., Liu, H., Wan, D., Wu, X., & Yin, Y. (2023) · Food & Function · doi:10.1039/d3fo03733a · Cited by 2 · see citing works
Hu, M., Liang, S., Wu, Q., Lee, C. S., Lu, J., Bao, S., Wu, C., & Liang, Z. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111841 · Cited by 2 · see citing works
Aljani, B., Garbe, A. I., Sedlmeier, E., Lickert, R., Rost, F., Ziegler, A., Bonifacio, E. E., & Eugster, A. (2024) · Placenta · doi:10.1016/j.placenta.2024.10.008 · Cited by 2 · see citing works
The Potential Impact of Maternal Milk Consumption During Pregnancy on mTORC1-Driven Fetal Growth
Melnik, B. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-14874-8_18 · Cited by 2 · see citing works
James‐Allan, L. B., Powell, T. L., & Jansson, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64683-4 · Cited by 2 · see citing works
Self-citationGalindo-Solano, N., Trejo-Villarreal, X., Díaz-Olivares, G., Rea-Palomino, G., Montes-Aguirre, D., Villagrán-Santa-Cruz, M., & Gutiérrez‐Ospina, G. (2025) · Brain Sciences · doi:10.3390/brainsci16010052 · Cited by 1 · see citing works
Connor, K. L., Souza, N. I. S., dos Anjos, B. G., Matthews, S. G., & Bloise, E. (2026) · The Journal of Physiology · doi:10.1113/jp289627 · Cited by 1 · see citing works
Glucose and Amino Acid and Their Roles in Placentation
Duttaroy, A. K., & Basak, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-38804-5_3 · Cited by 1 · see citing works
Carbohydrate Metabolism During Pregnancy
Chu, A., & Devaskar, S. U. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00040-8
Holme, A. M. (2018) · NORA - Norwegian Open Research Archives
Junien, C., Panchenko, P. E., Lacroix, M. C., Jouin, M., Badonnel, K., Lemaire, M., Meunier, N., Safi-Stibler, S., Jammes, H., Breton, C., et al. (2020) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2020.09.042
Physical activity during pregnancy alters gene expression in neonatal tissue
Reynolds, L. J., Vsevolozhskaya, O. A., Rice, B. B., Chavan, N. R., Dugan, A. J., Maddox, H. F., Preston, J. D., DeHoff, L. B., O’Brien, J., & Pearson, K. J. (2021) · Physiology International · doi:10.1556/2060.2021.00003
James‐Allan, L. B., Powell, T. L., & Jansson, T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00085-7 · Cited by 1 · see citing works
Self-citationGalagudza, M. M., Uspensky, Y. P., Fominykh, Y. A., Butko, D. Y., & Komar, V. V. (2025) · Translational Medicine · doi:10.18705/2311-4495-2025-12-3-268-282
Komar, V. V., Galagudza, M. M., Успенский, Ю. П., & Насыров, Р. А. (2025) · University therapeutic journal · doi:10.56871/utj.2025.49.25.002
- Authors
- Acosta, O., Ramirez, V. I., Lager, S., Gaccioli, F., Dudley, D. J., Powell, T. L., & Jansson, T.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Acosta, Ometeotl
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 212
- Issue
- 2
- Pages
- 227.e1-227.e7
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2062280233
- Cited by
- 102
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 17 · 2019: 13 · 2018: 5 · 2017: 5 · 2016: 12 · 2015: 9
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989, DK089989)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal obesity, large for gestational age, birth weight, maternal body mass index, syncytiotrophoblast, placental size
- MeSH terms
- Adult, Birth Weight, Blood Glucose, Female, Fetal Macrosomia, Humans, Infant, Newborn, Insulin, Male, Maternal-Fetal Exchange, Obesity, Organ Size, Placenta, Placentation, Pregnancy, Pregnancy Complications, Prospective Studies, Trophoblasts, Umbilical Veins, Cohort Studies, Body Mass Index, Case-Control Studies, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review