Increased Placental Nutrient Transport in a Novel Mouse Model of Maternal Obesity with Fetal Overgrowth

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Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes

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Regulation of Placental Nutrient Transport – A Review

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Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

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IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2

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Placental glucose transport and GLUT 1 expression in insulin-dependent diabetes

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Maternal hormones linking maternal body mass index and dietary intake to birth weight

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Review: Transport across the placenta of mice and women

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Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells

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Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.

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Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term

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Placental Glucose and Amino Acid Transport in Calorie-Restricted Wild-Type and Glut3 Null Heterozygous Mice

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Isolation of Plasma Membrane Vesicles from Mouse Placenta at Term and Measurement of System A and System β Amino Acid Transporter Activity

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Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas

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Effect of maternal dietary energy types on placenta nutrient transporter gene expressions and intrauterine fetal growth in rats

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Effects of maternal obesity on placental function and fetal development

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The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

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Placental Responses to Changes in the Maternal Environment Determine Fetal Growth

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Placental Function in Maternal Obesity

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Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

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Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth

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Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring

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Maternal pre-pregnancy body mass index, gestational weight gain influence birth weight

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Regulation of Placental Amino Acid Transport and Fetal Growth

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Parturition dysfunction in obesity: time to target the pathobiology

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Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring

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Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism

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Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation

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Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment

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Pregnancy‐induced changes in β‐cell function: what are the key players?

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A Western‐style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice

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Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis

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Activation of Placental Insulin and mTOR Signaling in a Mouse Model of Maternal Obesity Associated with Fetal Overgrowth

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Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice

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Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy

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Role of Obesity in Female Reproduction

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Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity

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Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions

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Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: Lessons from animal models

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Insulin Stimulates GLUT4 Trafficking to the Syncytiotrophoblast Basal Plasma Membrane in the Human Placenta

James‐Allan, L. B., Arbet, J., Teal, S. B., Powell, T. L., & Jansson, T. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02778 · Cited by 55 · see citing works

Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice†

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Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice

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Rodent models in placental research. Implications for fetal origins of adult disease

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Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner

Joselit, Y., Nanobashvili, K., Jack‐Roberts, C., Greenwald, E., Malysheva, O., Caudill, M. A., Saxena, A. D., & Jiang, X. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0035-z · Cited by 45 · see citing works

Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice

Vaughan, O. R., Rosario, F. J., Chan, J., Cox, L. A., Ferchaud‐Roucher, V., Berry, K. A. Z., Reusch, J. E. B., Keller, A. C., Powell, T. L., & Jansson, T. (2022) · The Journal of Physiology · doi:10.1113/jp282462 · Cited by 44 · see citing works

Effects of high-fat diets on fetal growth in rodents: a systematic review

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Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

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Regulation of placental amino acid transport in health and disease

Shimada, H., Powell, T. L., & Jansson, T. (2024) · Acta Physiologica · doi:10.1111/apha.14157 · Cited by 42 · see citing works

Role of Placental Glucose Transporters in Determining Fetal Growth

Joshi, N. P., Mane, A. R., Sahay, A. S., Sundrani, D. P., Joshi, S., & Yajnik, C. S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00699-9 · Cited by 38 · see citing works

Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring

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Antioxidants and Oxidative Stress: Focus in Obese Pregnancies

Alcalá, M., Gutiérrez-Vega, S., Castro, É., Guzmán‐Gutiérrez, E., Ramos, P., & Viana, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01569 · Cited by 36 · see citing works

Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin

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mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells

Rosario, F. J., Powell, T. L., Gupta, M. B., Cox, L. A., & Jansson, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.583801 · Cited by 34 · see citing works

Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring

Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0374-4 · Cited by 32 · see citing works

Effects of Maternal Obesity On Placental Phenotype

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The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams

Fornes, R., Maliqueo, M. A., Hu, M., Hadi, L., Jiménez‐Andrade, J. M., Ebefors, K., Nystrom, J. C., Labrie, F., Jansson, T., Benrick, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08559-w · Cited by 31 · see citing works

Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1)

Singh, N., Villoutreix, B. O., & Ecker, G. F. (2019) · Scientific Reports · doi:10.1038/s41598-019-51455-8 · Cited by 31 · see citing works

Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction

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Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies

Umano, G. R., Bellone, S., Buganza, R., Calcaterra, V., Corica, D., SANCTIS, L. D., Sessa, A. D., Faienza, M. F., Improda, N., Licenziati, M. R., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157388 · Cited by 37 · see citing works

Obesogenic diet exposure alters uterine natural killer cell biology and impairs vasculature remodeling in mice†

Baltayeva, J., Konwar, C., Castellana, B., Mara, D. L., Christians, J. K., & Beristain, A. G. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz163 · Cited by 29 · see citing works

Changes in Placental Nutrient Transporter Protein Expression and Activity Across Gestation in Normal and Obese Women

James‐Allan, L. B., Teal, S. B., Powell, T. L., & Jansson, T. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00173-y · Cited by 30 · see citing works

A maternal high-fat, high-sucrose diet has sex-specific effects on fetal glucocorticoids with little consequence for offspring metabolism and voluntary locomotor activity in mice

Chin, E. H., Schmidt, K. L., Martel, K. M., Wong, C. K., Hamden, J. E., Gibson, W. T., Soma, K. K., & Christians, J. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174030 · Cited by 28 · see citing works

Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model

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Childhood obesity from the genes to the epigenome

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Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3

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Normalization of maternal adiponectin in obese pregnant mice prevents programming of impaired glucose metabolism in adult offspring

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Adiponectin and Leptin during Pregnancy: A Systematic Review of Their Association with Pregnancy Disorders, Fetal Growth and Placental Function

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Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity

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Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring

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Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver

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Sex‐specific effects of leptin administration to pregnant mice on the placentae and the metabolic phenotypes of offspring

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N-acetylcysteine protects neonatal mice from ventricular hypertrophy induced by maternal obesity in a sex-specific manner

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Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations

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Lean maternal hyperglycemia alters offspring lipid metabolism and susceptibility to diet-induced obesity in mice†

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A mouse model of pre-pregnancy maternal obesity combined with offspring exposure to a high-fat diet resulted in cognitive impairment in male offspring

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Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity

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Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling

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Role of adipose tissue in regulating fetal growth in gestational diabetes mellitus

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Maternal High-Fat–High-Carbohydrate Diet-Induced Obesity Is Associated with Increased Appetite in Peripubertal Male but Not Female C57Bl/6J Mice

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METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

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Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse

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Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy

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Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome

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Transcriptomic responses are sex-dependent in the skeletal muscle and liver in offspring of obese mice

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Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism

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Cerebral Effects of Neonatal Dysglycemia

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Gestational exposure to BPA alters the expression of glucose and lipid metabolic mediators in the placenta: Role in programming offspring for obesity

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High-fat diet affects pregestational adiposity and glucose tolerance perturbing gestational placental macronutrient transporters culminating in an obese offspring in wild-type and glucose transporter isoform 3 heterozygous null mice

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Diet Modification before or during Pregnancy on Maternal and Foetal Outcomes in Rodent Models of Maternal Obesity

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Circular RNAs mediate the regulation of maternal placental nutrient transport and fetal development by sugar-sweetened beverages

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Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood

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Chemical Approaches for Studying the Biology and Pharmacology of Membrane Transporters: The Histidine/Large Amino Acid Transporter SLC7A5 as a Benchmark

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High early pregnancy body mass index is associated with alterations in first- and second-trimester angiogenic biomarkers

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Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit

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Trophoblast-specific overexpression of the LAT1 increases transplacental transport of essential amino acids and fetal growth in mice

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Reproductive and Behavior Dysfunction Induced by Maternal Androgen Exposure and Obesity Is Likely Not Gut Microbiome-Mediated

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Association between High-Fat Diet during Pregnancy and Heart Weight of the Offspring: A Multivariate and Mediation Analysis

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Amino Acid Composition of Amniotic Fluid during the Perinatal Period Reflects Mother’s Fat and Carbohydrate Intake

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Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in Mice

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Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences

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Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner

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Trophoblast‐specific overexpression of adiponectin receptor 2 causes fetal growth restriction in pregnant mice

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Ovarian inflammation mediated by Toll-like receptor 4 increased transcripts of maternal effect genes and decreased embryo development

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