The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain
Open accessAbstract
Epilepsy is considered as a common and diverse set of chronic neurological disorders and its symptoms can be controlled by antiepileptic drugs (AEDs). The presence of p-glycoprotein and multi-drug resistance transporters in the blood-brain barrier could prevent the entry of AEDs into the brain, causing drug resistant epilepsy. To overcome this problem, we propose using carboxymethyl chitosan nanoparticles as a carrier to deliver carbamazepine (CBZ) intra-nasally with the purpose to bypass the blood-brain barrier thus to enhance the brain drug concentration and the treatment efficacy. Results so far indicate that the developed CBZ-NPs have small particle size (218.76 ± 2.41 nm) with high drug loading (around 35%) and high entrapment efficiency (around 80%). The in vitro release profiles of CBZ from the NPs are in accordance with the Korsmeyer-peppas model. The in vivo results show that both encapsulation of CBZ in nanoparticles and the nasal route determined the enhancement of the drug bioavailability and brain targeting characteristics.
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Cites
Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies
Wu, W., He, Q., & Jiang, C. (2008) · Nanoscale Research Letters · doi:10.1007/s11671-008-9174-9 · Cited by 2,300
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107
Transport of drugs from the nasal cavity to the central nervous system
Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
Lockman, P. R., Mumper, R. J., Khan, M. A., & Allen, D. D. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120001481 · Cited by 592
Cited by
Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting
Garg, U., Chauhan, S., Nagaich, U., & Jain, N. (2019) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2019.023 · Cited by 505
Harugade, A., Sherje, A. P., & Pethe, A. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105634 · Cited by 474
Chitosan Based Materials in Cosmetic Applications: A Review
Kulka, K., & Sionkowska, A. (2023) · Molecules · doi:10.3390/molecules28041817 · Cited by 157
Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
Quispe, C., Herrera-Bravo, J., Javed, Z., Khan, K., Raza, S., Gulsunoglu-Konuskan, Z., Daştan, S. D., Sytar, O., Martorell, M., Sharifi-Rad, J., et al. (2022) · BioMed Research International · doi:10.1155/2022/1375892 · Cited by 92
Yee Kuen, C., & Masarudin, M. J. (2022) · Molecules · doi:10.3390/molecules27020473 · Cited by 78
Metadata
- Authors
- Liu, S., Yang, S., & Ho, P. C.
- Venue
- Asian Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 13
- Issue
- 1
- Pages
- 72-81
- ISSN
- 1818-0876 (ISSN-L)
- OpenAlex
- W2756173910
- Cited by
- 213
- References
- 4
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Liu, S., Yang, S., & Ho, P. C. (2018). Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain. Asian Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.ajps.2017.09.001
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