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Cited by 32Neuroscience and Neuropharmacology ResearchPrenatal Substance Exposure EffectsNeurotransmitter Receptor Influence on Behavior

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Repeated ethanol treatment in adolescent rats alters cortical NMDA receptor

Sircar, Ratna, Sircar, Debashish·2006·Alcohol
DOI 10.1016/j.alcohol.2006.07.002
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Abstract

Earlier we have reported that repeated ethanol treatment during adolescence causes long-lasting impairments in spatial learning and memory. The present study was undertaken to determine the cellular mechanisms underlying the persistent ethanol-induced cognitive dysfunction in adolescent male rats. Since in adult animals ethanol is known to affect the N-methyl-d-aspartate (NMDA) receptor-gated ion channel, the hypothesis tested here was that adolescent ethanol exposure modulates NMDA receptor (NR) regulation in the brain. Adolescent male rats were injected daily with ethanol (2g/kg intraperitoneally) for 5 consecutive days. Control rats received isovolumetric saline for the same number of days. Groups of control and experimental rats were sacrificed 7 days after the last ethanol/saline administration, and NR activity was measured in specific brain regions (frontal cortex, hippocampus) using the [(3)H]MK-801 binding assay. In addition, some rats were sacrificed and their brains were used to investigate changes in NR pharmacology by measuring specific NR2 subunits immunohistochemically. Compared to saline-treated controls, ethanol-treated rats showed significant increases in [(3)H]MK-801 maximal binding in the frontal cortex. This was associated with increased cortical NR2B subunit protein. [(3)H]MK-801 binding in the hippocampus was minimally affected. These results indicate that ethanol exposure during the adolescent period produces brain region-specific alterations in NR acti…

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Metadata

Authors
Sircar, R., & Sircar, D.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Sircar, Ratna
ORCID
Sircar, Ratna
Venue
Alcohol
Publisher
Elsevier BV
Published
2006-05
Volume
39
Issue
1
Pages
51-58
ISSN
0741-8329 (ISSN-L)
DOI
10.1016/j.alcohol.2006.07.002
OpenAlex
W2058290849
Cited by
32
References
5
Citations by year
2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 2
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Alcohol (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R21AA013396, AA13396)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
adolescent ethanol exposure, NMDA receptor, NR2B subunit, frontal cortex, hippocampus, cognitive impairment, spatial learning and memory, brain development, alcohol sensitivity, MK-801 binding
MeSH terms
Aging, Ethanol, Animals, Cerebral Cortex, Hippocampus, Male, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Rats, Sprague-Dawley, Rats

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