A comparison of the effects of medial prefrontal, cingulate cortex, and cingulum bundle lesions on tests of spatial memory: evidence of a double dissociation between frontal and cingulum bundle contributions
Open accessAbstract
Rats were trained on an automated delayed nonmatching-to-position (DNMP) task. They then received cytotoxic lesions in either the medial prefrontal cortex (n = 13) or the cingulate and retrosplenial cortices (n = 8), or radiofrequency lesions in either the fornix (n = 6) or the cingulum bundle (n = 8). Twelve animals served as surgical controls. Only the fornical and medial prefrontal lesions disrupted DNMP performance, both groups showing a loss of accuracy and an increase in bias. The rats were then trained on a lever discrimination and reversal task, the medial prefrontal and fornical groups showing evidence of an increase in bias when compared with the cingulate cortex group. Finally, the rats were trained on a forced alternation task in a T- maze. Marked deficits were observed in the fornix and cingulum bundle groups, but the medial prefrontal and cingulate groups were unimpaired. The double dissociation between the effects of the prefrontal and cingulum bundle lesions highlights the very different nature of the two spatial tasks (DNMP and T-maze alternation), even though both involved a nonmatching rule. These findings may reflect the involvement of divergent outputs from the fornix-anterior thalamic pathway. One possibility is that anterior thalamic projections to the medial prefrontal cortex are concerned with processing egocentric information, while anterior thalamic projections to temporal regions via the cingulum bundle are concerned with allocentric information. The results also indicate that the effects of conventional lesions in the cingulate cortex and medial prefrontal cortex may be compromised by additional damage to the cingulum bundle.
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Fornix and anterior thalamic lesions, as well as hippocampal and medial prefrontal lesions, persistently impair delayed nonmatching-to-position.
“In contrast, both fornix and anterior thalamic lesions, as well as hippocampal and medial prefrontal lesions (Aggleton et al., 1992, 1995), persistently impair this task.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Aggleton et al., 1995
The introduction reports that hippocampal, fornix, and anterior thalamic lesions produce severe deficits on spatial tasks including delayed nonmatching-to-position. The paper also reports fornix and medial prefrontal DNMP deficits when rats were retested about six weeks after surgery (Subjects; Comparisons among animals with medial prefrontal lesions). It does not establish that the hippocampal and anterior thalamic deficits persist, so the claim’s persistence qualifier is not supported for all four lesion types. (LLM, conf=0.82)
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- Authors
- Aggleton, J., Neave, N., Nagle, S., & Sahgal, A.
- Affiliations
- Durham University (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-11-01
- Volume
- 15
- Issue
- 11
- Pages
- 7270-7281
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6578066
- OpenAlex
- W2129684141
- Cited by
- 196
- References
- 34
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Northumbria Research Link (Northumbria University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- spatial memory, medial prefrontal cortex, cingulate cortex, cingulum, fornix, double dissociation, reversal learning, T-maze, retrosplenial cortex
- MeSH terms
- Animals, Discrimination, Psychological, Gyrus Cinguli, Hippocampus, Male, Memory, Rats, Inbred Strains, Space Perception, Prefrontal Cortex, Maze Learning, Rats
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