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Cited by 32Neuroscience and Neuropharmacology ResearchPrenatal Substance Exposure EffectsNeurotransmitter Receptor Influence on Behavior

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Repeated ethanol treatment in adolescent rats alters cortical NMDA receptor

Sircar, Ratna, Sircar, Debashish·2006·Alcohol
DOI 10.1016/j.alcohol.2006.07.002
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Abstract

Earlier we have reported that repeated ethanol treatment during adolescence causes long-lasting impairments in spatial learning and memory. The present study was undertaken to determine the cellular mechanisms underlying the persistent ethanol-induced cognitive dysfunction in adolescent male rats. Since in adult animals ethanol is known to affect the N-methyl-d-aspartate (NMDA) receptor-gated ion channel, the hypothesis tested here was that adolescent ethanol exposure modulates NMDA receptor (NR) regulation in the brain. Adolescent male rats were injected daily with ethanol (2g/kg intraperitoneally) for 5 consecutive days. Control rats received isovolumetric saline for the same number of days. Groups of control and experimental rats were sacrificed 7 days after the last ethanol/saline administration, and NR activity was measured in specific brain regions (frontal cortex, hippocampus) using the [(3)H]MK-801 binding assay. In addition, some rats were sacrificed and their brains were used to investigate changes in NR pharmacology by measuring specific NR2 subunits immunohistochemically. Compared to saline-treated controls, ethanol-treated rats showed significant increases in [(3)H]MK-801 maximal binding in the frontal cortex. This was associated with increased cortical NR2B subunit protein. [(3)H]MK-801 binding in the hippocampus was minimally affected. These results indicate that ethanol exposure during the adolescent period produces brain region-specific alterations in NR acti…

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Research works printed but not linked: 70

  1. Acheson, 1998, Impairment of semantic and figural memory by acute ethanol: age-dependent effects, Alcohol Clin Exp Res, 22, 1437, 10.1111/j.1530-0277.1998.tb03932.x · DOI
  2. Alele, 2005, Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats, Alcohol Clin Exp Res, 29, 1027, 10.1097/01.ALC.0000167743.96121.40 · DOI
  3. Allen, 2000, Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms, J Neurosci, 20, 3537, 10.1523/JNEUROSCI.20-10-03537.2000 · DOI
  4. Anisman, 1972, Fear reduction and active avoidance learning after alcohol administration during prior CS-shock exposure, Quart J Studies Alcohol, 33, 783, 10.15288/qjsa.1972.33.783 · DOI
  5. Becker, 1980, Neuroanatomical bases of spatial memory, Brain Res, 200, 307, 10.1016/0006-8993(80)90922-1 · DOI
  6. Brown, 2000, Neurocognitive functioning of adolescents: effects of protracted alcohol use, Alcohol Clin Exp Res, 24, 164, 10.1111/j.1530-0277.2000.tb04586.x · DOI
  7. Buller, 1993, Interaction of ethanol with recombinant heteromeric NMDA receptors expressed in Xenopus oocytes, Alcohol Clin Exp Res, 17, 475
  8. Crews, 2000, Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats, Alcohol Clin Exp Res, 24, 1712, 10.1111/j.1530-0277.2000.tb01973.x · DOI · Paper page
  9. Darstein, 2000, Changes in NMDA receptor subunit gene expression in the rat brain following withdrawal from forced long-term ethanol intake, Naunyn Schmiedebergs Arch Pharmacol, 361, 206, 10.1007/s002109900180 · DOI
  10. Devaud, 2004, Differential effects of chronic ethanol administration and withdrawal on gamma-aminobutyric acid type A and NMDA receptor subunit proteins in male and female rat brain, Alcohol Clin Exp Res, 28, 957, 10.1097/01.ALC.0000128225.83916.40 · DOI
  11. Devenport, 1983, Effects of ethanol on enforced spatial variability in the 8-arm radial maze, Pharmacol Biochem Behav, 18, 55, 10.1016/0091-3057(83)90251-4 · DOI
  12. Diaz-Granados, 1997, Effects of prenatal and early postnatal ethanol exposure on [3H]MK-801 binding in rat cortex and hippocampus, Alcohol Clin Exp Res, 21, 874, 10.1097/00000374-199708000-00016 · DOI
  13. Dutar, 2000, Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice, Neuroscience, 112, 455, 10.1016/S0306-4522(02)00074-X · DOI
  14. Follesa, 1995, Chronic ethanol treatment differentially regulates NMDA subunit receptor subunit mRNA expression in rat brain, Mol Brain Res, 29, 99, 10.1016/0169-328X(94)00235-7 · DOI
  15. Goodlett, 1987, Early postnatal alcohol exposure that produces high blood alcohol levels impairs development of spatial navigation learning, Psychobiology, 15, 64, 10.3758/BF03327265 · DOI
  16. Grant, 1990, Ethanol withdrawal seizures and the NMDA receptor complex, Eur J Pharmacol, 176, 289, 10.1016/0014-2999(90)90022-X · DOI
  17. Gulya, 1991, Brain regional specificity and time course of changes in the NMDA receptor ionophore complex during ethanol withdrawal, Brain Res, 547, 129, 10.1016/0006-8993(91)90125-F · DOI
  18. Haugbol, 2005, Upregulation of glutamate receptor subtypes during alcohol withdrawal in rats, Alcohol Alcohol, 40, 89, 10.1093/alcalc/agh117 · DOI
  19. Hoffman, 1996, Alcohol dependence: a commentary on mechanisms, Alcohol Clin Exp Res, 31, 333
  20. Hoffman, 1989, N-methyl-d-aspartate receptors and ethanol: inhibition of calcium flux and cGMP production, J Neurochem, 52, 1937, 10.1111/j.1471-4159.1989.tb07280.x · DOI
  21. Honse, 2003, Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil, Alcohol Clin Exp Res, 27, 1993, 10.1097/01.ALC.0000099029.55026.C6 · DOI
  22. Hughes, 1998, Effect of prenatal ethanol exposure on the developmental profile of the N-methyl-d-aspartate receptor subunits in rat forebrain and hippocampus, Alcohol Clin Exp Res, 22, 1255, 10.1111/j.1530-0277.1998.tb03906.x · DOI
  23. Jernigan, 1991, Maturation of human cerebrum observed in vivo during adolescence, Brain, 114, 2037, 10.1093/brain/114.5.2037 · DOI · Paper page
  24. Kalluri, 1998, Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatments, Mol Brain Res, 58, 221, 10.1016/S0169-328X(98)00112-0 · DOI
  25. Larsson, 2005, Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat, Alcohol Alcohol, 40, 349, 10.1093/alcalc/agh180 · DOI
  26. Laurie, 1994, Ligand affinities at recombinant N-methyl-d-aspartate receptors depend on subunit composition, Eur J Pharmacol, 268, 335, 10.1016/0922-4106(94)90058-2 · DOI
  27. Lee, 2003, Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory, J Neurosci, 23, 1517, 10.1523/JNEUROSCI.23-04-01517.2003 · DOI
  28. Li, 2002, Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats, J Neurophysiol, 87, 705, 10.1152/jn.00433.2001 · DOI
  29. Little, 1996, Differential effects of ethanol in adolescent and adult rats, Alcohol Clin Exp Res, 20, 1346, 10.1111/j.1530-0277.1996.tb01133.x · DOI
  30. Lovinger, 1989, Ethanol inhibits NMDA–activated ion current in hippocampal neurons, Science, 243, 1721, 10.1126/science.2467382 · DOI
  31. Lynch, 2004, Long-term potentiation, Physiol Rev, 84, 87, 10.1152/physrev.00014.2003 · DOI
  32. Ma, 2003, Dissociation of egocentric and allocentric spatial processing in prefrontal cortex, Neuroreport, 14, 1737, 10.1097/00001756-200309150-00016 · DOI
  33. Magnusson, 1998, Aging of glutamate receptors: correlations between binding and spatial memory performance in mice, Mech Ageing Dev, 104, 227, 10.1016/S0047-6374(98)00076-1 · DOI
  34. Markwiese, 1998, Differential effects of ethanol on memory in adolescent and adult rats, Alcohol Clin Exp Res, 22, 416, 10.1111/j.1530-0277.1998.tb03668.x · DOI · Paper page
  35. Matthews, 1995, Acute ethanol impairs spatial memory but not stimulus/response memory in the rat, Alcohol Clin Exp Res, 19, 902, 10.1111/j.1530-0277.1995.tb00965.x · DOI
  36. Maylor, 1988, Effects of alcohol on lexical access, Psycopharmacology (Berl), 95, 119
  37. Mehta, 2005, Effect of chronic administration of ethanol on GABAA receptor assemblies derived from α2-, α3-, β2- and γ2-subunits in the rat cerebral cortex, Brain Res, 1031, 134, 10.1016/j.brainres.2004.11.001 · DOI
  38. Melia, 1996, Hippocampal-dependent learning and experience-dependent activation of the hippocampus are preferentially disrupted by ethanol, Neuroscience, 74, 313, 10.1016/0306-4522(96)00138-8 · DOI
  39. Miotto, 1996, Spatial working memory and strategy formation in patients with frontal lobe excisions, Cortex, 32, 613, 10.1016/S0010-9452(96)80034-7 · DOI
  40. Monyer, 1994, Developmental and regional expression in the rat brain and functional properties of four NMDA receptors, Neuron, 12, 529, 10.1016/0896-6273(94)90210-0 · DOI · Paper page
  41. O'Keefe, 1979, A review of the hippocampal place cells, Prog Neurobiol, 13, 419, 10.1016/0301-0082(79)90005-4 · DOI
  42. Omari, 2005, CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis, Brain, 128, 1003, 10.1093/brain/awh479 · DOI
  43. Parsons, 1977, Neuropsychological deficits in alcoholics: facts and fancies, Alcohol Clin Exp Res, 1, 51, 10.1111/j.1530-0277.1977.tb05767.x · DOI
  44. Piyapali, 1999, Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation, Alcohol, 19, 107, 10.1016/S0741-8329(99)00021-X · DOI
  45. Qiang, 2005, Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons, J Neurochem, 95, 1332, 10.1111/j.1471-4159.2005.03464.x · DOI
  46. Ramoa, 1997, Retinal activity regulates developmental switches in functional properties and ifenprodil sensitivity of NMDA receptors in the lateral geniculate nucleus, Dev Brain Res, 101, 165, 10.1016/S0165-3806(97)00061-8 · DOI
  47. Riekkinen, 1992, Effects of tetrahydroaminoacridine on spatial navigation of nucleus-basalis- and frontal-cortex-lesioned rats, Pharmacol Biochem Behav, 41, 637, 10.1016/0091-3057(92)90385-S · DOI
  48. Rossetti, 1999, Glutamate-induced increase of extracellular glutamate through N-methyl-D-aspartate receptors in ethanol withdrawal, Neuroscience, 93, 1135, 10.1016/S0306-4522(99)00250-X · DOI · Paper page
  49. Savage, 1991, Prenatal ethanol exposure decreases hippocampal NMDA–sensitive [3H] glutamate binding site density in 45-day-old rats, Alcohol, 8, 193, 10.1016/0741-8329(91)90806-8 · DOI
  50. Savage, 1991, Prenatal ethanol exposure during the last third of gestation in rat reduces hippocampal NMDA agonist binding site density in 45-day-old offspring, Alcohol, 9, 37, 10.1016/0741-8329(92)90007-W · DOI
  51. Schuster, 1997, Comparison of the behavioral and morphological effects of colchicine- or neutral fluid-induced destruction of granule cells in the dentate gyrus of the rat, Neurobiol Learn Mem, 68, 86, 10.1006/nlme.1997.3775 · DOI
  52. Sheng, 1994, Changing subunit composition of heteromeric NMDA receptors during development of rat cortex, Nature, 368, 144, 10.1038/368144a0 · DOI · Paper page
  53. Silveri, 1998, Decreased sensitivity to the hypnotic effects of ethanol early in ontogeny, Alcohol Clin Exp Res, 22, 670, 10.1111/j.1530-0277.1998.tb04310.x · DOI
  54. Silveri, 2000, Ontogeny of ethanol elimination and ethanol-induced hypothermia, Alcohol, 20, 45, 10.1016/S0741-8329(99)00055-5 · DOI
  55. Sircar, 2000, Developmental maturation of the N-methyl-d-aspartic acid receptor channel complex in postnatal rat brain, Int J Dev Neurosci, 18, 121, 10.1016/S0736-5748(99)00069-6 · DOI
  56. Sircar, 2004, Adolescent γ-hydroxybutyric acid exposure decreases cortical N-methyl-d-aspartate receptor and impairs spatial learning, Pharmacol Biochem Behav, 79, 701, 10.1016/j.pbb.2004.09.022 · DOI
  57. Sircar, 1996, Chronic neonatal PCP differentially regulates mRNA levels for NMDA receptor subunits, Mol Brain Res, 40, 214, 10.1016/0169-328X(96)00051-4 · DOI
  58. Sircar, 1987, The novel anticonvulsant MK-801: a potent and specific ligand of the brain phencyclidine/σ receptor, Brain Res, 435, 235, 10.1016/0006-8993(87)91606-4 · DOI
  59. Sircar, 2005, Adolescent rats exposed to repeated ethanol treatment show lingering behavioral impairments, Alcohol Clin Exp Res, 29, 1402, 10.1097/01.alc.0000175012.77756.d9 · DOI
  60. Snell, 2001, Chronic ethanol exposure delays the ‘developmental switch’ of the NMDA receptor 2A and 2B subunits in cultured cerebellar granule neurons, J Neurochem, 78, 396, 10.1046/j.1471-4159.2001.00424.x · DOI
  61. Snell, 1996, Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion, Mol Brain Res, 40, 71, 10.1016/0169-328X(96)00038-1 · DOI
  62. Spuhler-Phillips, 1995, Alteration of [3H]MK-801 binding associated with the N-methyl-d-aspartate receptor complex by acute ethanol in rat cortex and hippocampus in vitro, Alcohol Clin Exp Res, 19, 305, 10.1111/j.1530-0277.1995.tb01507.x · DOI
  63. Swartzwelder, 1998, Developmental differences in the acquisition of tolerance to ethanol, Alcohol, 15, 311, 10.1016/S0741-8329(97)00135-3 · DOI
  64. Swartzwelder, 1995, Differential sensitivity on NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus, Alcohol Clin Exp Res, 19, 320, 10.1111/j.1530-0277.1995.tb01509.x · DOI
  65. Tang, 1999, Genetic enhancement of learning and memory in mice, Nature, 401, 63, 10.1038/43432 · DOI
  66. Trevisan, 1994, Chronic ingestion of ethanol upregulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus, J Neurochem, 62, 1635, 10.1046/j.1471-4159.1994.62041635.x · DOI
  67. Valles, 1995, Alcohol exposure during development reduces [3H]MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus, Life Sci, 56, 1373, 10.1016/0024-3205(95)00101-8 · DOI
  68. Valverius, 1990, NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures, Eur J Pharmacol, 184, 185, 10.1016/0014-2999(90)90681-U · DOI
  69. White, 2004, Hippocampal function during adolescence: a unique target of ethanol effects, Ann NY Acad Sci, 1021, 206, 10.1196/annals.1308.026 · DOI
  70. Williams, 1993, Developmental switch in the expression of NMDA receptors occurs in in vivo and in vitro, Neuron, 10, 267, 10.1016/0896-6273(93)90317-K · DOI

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Metadata

Authors
Sircar, R., & Sircar, D.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Sircar, Ratna
ORCID
Sircar, Ratna
Venue
Alcohol
Publisher
Elsevier BV
Published
2006-05
Volume
39
Issue
1
Pages
51-58
ISSN
0741-8329 (ISSN-L)
DOI
10.1016/j.alcohol.2006.07.002
OpenAlex
W2058290849
Cited by
32
References
5
Citations by year
2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 2
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Alcohol (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R21AA013396, AA13396)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
adolescent ethanol exposure, NMDA receptor, NR2B subunit, frontal cortex, hippocampus, cognitive impairment, spatial learning and memory, brain development, alcohol sensitivity, MK-801 binding
MeSH terms
Aging, Ethanol, Animals, Cerebral Cortex, Hippocampus, Male, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Rats, Sprague-Dawley, Rats

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