The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regression in Autism: Prevalence and Associated Factors in the CHARGE Study
Abstract
Objective The aim of this study was to examine the prevalence of regressive autism and associated demographic, medical, and developmental factors by using 2 different definitions of regression based on the Autism Diagnostic Interview, Revised. Methods Subjects were aged 2 to 5 years, with autism (AU) or autism spectrum disorder (ASD) confirmed by standardized measures. Children with regression, defined as a) loss of both language and social skills or b) loss of either language or social skills, were compared with each other and to children with AU or ASD with no reported loss of skills on developmental and adaptive functioning. Parents reported on seizure, gastrointestinal, and sleep concerns. Results Fifteen percent (50/333) of the combined AU-ASD group lost both language and social skills; 41% (138/333) lost either language or social skills. No differences were found between the 2 samples of children with regression. Few developmental, demographic, or medical differences were found between the combined regression group and children without loss of skills, in both the larger AU-ASD sample and the more homogeneous AU-only sample. Children with regression had significantly lower communication scores than children without regression. Conclusions The prevalence of regression in a large sample of young children with AU and ASD varies depending on the definition used; requiring loss of language significantly underestimates the frequency of developmental regression. Children with r…
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“A recent meta-analysis suggested a mean prevalence of parentreported regression of 32% (Barger et al. 2013), but rates vary depending on how stringent a definition is employed (Hansen et al. 2008, Stefanatos 2008).”
From Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder (2015) · cites this paper as Hansen et al. 2008
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Cited by
Sorted by citations
A Prospective Study of the Emergence of Early Behavioral Signs of Autism
Ozonoff, S., Iosif, A.-M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., Rogers, S. J., Rozga, A., Sangha, S., Sigman, M., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.11.009 · Cited by 1,011
Self-citationAshwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940
“Children confirmed as ASD were divided into subgroups of nonregressive or regressive autism based on the stage of development the child began to display autistic behavior (Hansen et al., 2008).”
BackgroundSelf-citationDevelopmental pathways to autism: A review of prospective studies of infants at risk
Jones, E. J. H., Gliga, T., Bedford, R., Charman, T., & Johnson, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.001 · Cited by 607
Geschwind, D. H. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.053107.121225 · Cited by 512
Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., Loth, E., McAlonan, G. M., McCracken, J. T., Parr, J. R., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117741766 · Cited by 342
“However, it is noteworthy that not all head circumference or magnetic resonance imaging (MRI) volumetric studies support this model (Hansen et al., 2008; Raznahan et al., 2013a,b; Rogers, 2004).”
Metadata
- Authors
- Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., Deprey, L. J., Le, D.-N., Croen, L. A., & Hertz-Picciotto, I.
- Affiliations
- University of California Davis Medical Center (US)
- University of California, Davis (US)
- Venue
- Ambulatory Pediatrics
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 8
- Issue
- 1
- Pages
- 25-31
- ISSN
- 1530-1567 (ISSN-L)
- OpenAlex
- W2094395178
- Cited by
- 164
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 12 · 2018: 4 · 2017: 14 · 2016: 6 · 2015: 6 · 2014: 12 · 2013: 20 · 2012: 18
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ambulatory Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (1 P01-ES11269, R01ES015359, P01ES011269)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- regressive autism, developmental regression, autism spectrum disorder, language loss, communication outcomes, young children, CHARGE study, gastrointestinal symptoms, seizures, sleep disorders
- MeSH terms
- Adaptation, Psychological, Autistic Disorder, Child, Preschool, Female, Humans, Language Disorders, Male, Regression, Psychology, Social Behavior Disorders, Prevalence
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