Is There a ‘Regressive Phenotype’ of Autism Spectrum Disorder Associated with the Measles-Mumps-Rubella Vaccine? A CPEA Study
Abstract
A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.
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These findings support the potential of a subtype of ASD with comorbid SLI and unique underlying biological mechanisms.
“further supporting the potential of a subtype of ASD with comorbid SLI and unique underlying biological mechanisms [57].”
From DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes (2013) · cites this paper as [57]
Cites
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Self-citation
- Authors
- Richler, J., Luyster, R., Risi, S., Hsu, W.-L., Dawson, G., Bernier, R., Dunn, M., Hepburn, S., Hyman, S. L., McMahon, W. M., Goudie-Nice, J., Minshew, N., Rogers, S., Sigman, M., Spence, M. A., Goldberg, W. A., Tager-Flusberg, H., Volkmar, F. R., & Lord, C.
- Affiliations
- University of Michigan (US)
- University of Washington (US)
- Albert Einstein College of Medicine (US)
- University of Colorado Health (US)
- University of Rochester (US)
- University of Utah (US)
- University of Pittsburgh (US)
- University of California, Davis (US)
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- Boston University (US)
- Yale University (US)
- Corresponding author
- Lord, Catherine
- ORCID
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2006-04
- Volume
- 36
- Issue
- 3
- Pages
- 299-316
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2000764724
- Cited by
- 149
- References
- 2
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 2 · 2023: 5 · 2021: 10 · 2020: 1 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 13 · 2012: 16
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Los Angeles
- Medical Center, University of Rochester
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD35482, P01HD035482)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, regression analysis, MMR vaccine, vaccine safety, social reciprocity, verbal IQ, gastrointestinal symptoms, age of onset, atypical development
- MeSH terms
- Autistic Disorder, Child, Communication, Female, Humans, Male, Parents, Phenotype, Surveys and Questionnaires, Regression, Psychology, Social Behavior, Observer Variation, Measles-Mumps-Rubella Vaccine
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