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Cited by 157Cardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)**The views expressed here are those of the authors and do not necessarily reflect those of the Indian Health Service.

Chinali, Marcello, Devereux, Richard B, Howard, Barbara V, Roman, Mary J, Bella, Jonathan N, Liu, Jennifer E, Resnick, Helaine E, Lee, Elisa T +2 more·2004·The American Journal of Cardiology
DOI 10.1016/j.amjcard.2003.09.009
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Abstract

The metabolic syndrome (MS) is linked to cardiovascular risk. Recently, the Adult Treatment Panel (ATP) III provided new criteria for the definition of the MS. We analyzed the impact of the MS on cardiac structure and function and the independent association of the 5 different components of the ATP III-defined MS with cardiac markers of preclinical disease. Echocardiographic examination was performed in 612 nondiabetic participants with ATP III-defined MS and in 824 participants without the MS. Participants with the MS were more often women (p <0.001) and had similar ages compared with those without the MS. After controlling for confounders, participants with the MS had greater left ventricular (LV) dimension, mass, and relative wall thickness, and left atrial diameter (all p </=0.01), and a higher prevalence of LV hypertrophy (p <0.001), with lower ejection fraction (p <0.05), midwall shortening (p <0.001), and mitral E/A ratio (p <0.05) than participants who did not have the MS. In multiple regression modeling, high blood pressure (BP) and abdominal obesity were the only components of the MS associated with increased LV diameter; only high BP was associated with increased LV mass and prevalence of LV hypertrophy (both p <0.001). When high to normal BP was present in the absence of hypertension, the MS exhibited LV geometry similar to hypertensive participants without the MS. Therefore, abnormal LV geometry and function are related to the MS. Increased BP is the component of the MS most strongly associated with cardiac markers of preclinical disease, even in the absence of traditionally defined hypertension.

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  • Stroke volume and cardiac output are both increased in obese individuals.

    “In addition, stroke volume and cardiac output are both increased (13, 49, 165, 170, 284).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [49]

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Authors
Chinali, M., Devereux, R. B., Howard, B. V., Roman, M. J., Bella, J. N., Liu, J. E., Resnick, H. E., Lee, E. T., Best, L. G., & de Simone, G.
Affiliations
  • NewYork–Presbyterian Hospital (US)
  • MedStar Health Research Institute (US)
  • University of Oklahoma (US)
  • Missouri Breaks Industries Research (United States) (US)
Corresponding author
Devereux, Richard B
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2004-01
Volume
93
Issue
1
Pages
40-44
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/j.amjcard.2003.09.009
OpenAlex
W2024404644
Cited by
157
References
24
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 12 · 2014: 12 · 2013: 7 · 2012: 3
FWCI
5.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (U01HL041652, U01HL041654, U01 HL-41642, U01HL 41652, U01HL41654, U01HL041642)
  • National Center for Research Resources (M10RR0047-34)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
metabolic syndrome, Native Americans, left ventricular hypertrophy, left ventricular geometry, left ventricular function, left atrial diameter, ejection fraction, systolic dysfunction, hypertension, abdominal obesity, preclinical cardiovascular disease, Strong Heart Study
MeSH terms
Aged, Arizona, Body Composition, Echocardiography, Female, Heart Ventricles, Humans, Indians, North American, Male, Middle Aged, Risk Factors, Midwestern United States, Prevalence, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Genetic Predisposition to Disease, Metabolic Syndrome

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