Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism

LIAO, Y; TAKASHIMA, S; MAEDA, N; OUCHI, N; KOMAMURA, K; SHIMOMURA, I; HORI, M; MATSUZAWA, Y; FUNAHASHI, T; KITAKAZE, M

doi:10.1016/j.cardiores.2005.04.018

Cited by 236Cardiac Fibrosis and RemodelingAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism

LIAO, Y, TAKASHIMA, S, MAEDA, N, OUCHI, N, KOMAMURA, K, SHIMOMURA, I, HORI, M, MATSUZAWA, Y +2 more·2005·Cardiovascular Research

DOI 10.1016/j.cardiores.2005.04.018

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Insulin resistance (IR) was reported to be associated with chronic heart failure (CHF). Adiponectin, an insulin-sensitizing hormone with anti-inflammatory activity, improves energy metabolism via AMP-activated protein kinase (AMPK). AMPK deficiency is associated with depressed cardiac function under stress conditions. However, it is not clear whether adiponectin plays an important role in CHF. We hypothesize that deficiency of adiponectin might result in deterioration of heart failure. METHODS: Using adiponectin null mice and their littermates, we examined the effects of adiponectin on LV pressure overload-induced cardiac hypertrophy and failure, and investigated the mechanisms involved. RESULTS: Three weeks after transverse aortic constriction (TAC), cardiac hypertrophy (evaluated from the heart-to-body weight ratio: 7.62+/-0.27 in wild-type (WT) mice, 9.97+/-1.13 in knockout (KO) mice, P<0.05) and pulmonary congestion (lung-to-body weight ratio: 9.05+/-1.49 in WT mice, 14.95+/-2.36 in KO mice, P<0.05) were significantly greater in adiponectin KO mice than WT mice. LV dimensions were also increased in KO mice. Compared with WT TAC mice, expression of AMPKalpha protein was lower, while IR was higher in KO TAC mice. CONCLUSION: These findings indicate that adiponectin deficiency leads to progressive cardiac remodeling in pressure overloaded condition mediated via lowing AMPK signaling and impaired glucose metabolism.

Integrity signals

Registry

Crossref · 10.1016/j.cardiores.2005.04.018

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Adiponectin deficiency enhanced progressive cardiac remodeling induced by surgical aortic constriction in adiponectin KO mice.
“With the use of adiponectin KO mice, it was shown that adiponectin deficiency enhanced progressive cardiac remodeling induced by surgical aortic constriction (208).”
From Cardiac remodeling in obesity (2008) · cites this paper as [208]

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.
(2002) · Circulation · doi:10.1161/circ.106.25.3143 · Cited by 14,092 · see citing works
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033 · see citing works
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,086 · see citing works
Self-citation
Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults
Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,845 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
AMP‐activated protein kinase phosphorylation of endothelial NO synthase
Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
Russell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19297 · Cited by 738 · see citing works
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
Bråkenhielm, E., Veitonmäki, N., Cao, R., Kihara, S., Matsuzawa, Y., Zhivotovsky, B., Funahashi, T., & Cao, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308671100 · Cited by 734 · see citing works
Self-citation
Adiponectin-mediated modulation of hypertrophic signals in the heart
Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671 · see citing works
Self-citation
C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring Study
Rutter, M. K., Meigs, J. B., Sullivan, L. M., D’Agostino, R. B., & Wilson, P. W. F. (2004) · Circulation · doi:10.1161/01.cir.0000136581.59584.0e · Cited by 664 · see citing works
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
Nakae, J., Biggs, W., Kitamura, T., Cavenee, W. K., Wright, C. V. E., Arden, K. C., & Accili, D. (2002) · Nature Genetics · doi:10.1038/ng890 · Cited by 616 · see citing works
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Beilby, J. P. (2004) · PubMed Central · Cited by 613 · see citing works
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity
Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402367200 · Cited by 550 · see citing works
Adrenocortical, Autonomic, and Inflammatory Causes of the Metabolic Syndrome: Nested Case-Control Study
Brunner, E. J., Hemingway, H., Walker, B. R., Page, M., Clarke, P., Juneja, M., Shipley, M. J., Kumari, M., Andrew, R., Seckl, J. R., et al. (2002) · Circulation · doi:10.1161/01.cir.0000038364.26310.bd · Cited by 539 · see citing works
Insulin Resistance in Chronic Heart Failure: Relation to Severity and Etiology of Heart Failure
Swan, J. W., Anker, S. D., Walton, C., Godsland, I. F., Clark, A. L., Leyva, F., Stevenson, J. C., & Coats, A. J. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00185-x · Cited by 532 · see citing works
Impact of Glucose Intolerance and Insulin Resistance on Cardiac Structure and Function: Sex-Related Differences in the Framingham Heart Study
Rutter, M. K., Parise, H., Benjamin, E. J., Levy, D., Larson, M. G., Meigs, J. B., Nesto, R. W., Wilson, P. W. F., & Vasan, R. S. (2003) · Circulation · doi:10.1161/01.cir.0000045671.62860.98 · Cited by 511 · see citing works
Syndrome X and Mortality: A Population-based Study
Trevisan, M., Liu, J., Bahsas, F. B., & Menotti, A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009572 · Cited by 389 · see citing works
Role of Adipocytokines on the Pathogenesis of Atherosclerosis in Visceral Obesity.
Funahashi, T., Nakamura, T., Shimomura, I., Maeda, K., Kuriyama, H., Takahashi, M., ARITA, Y., Kihara, S., & Matsuzawa, Y. (1999) · Internal Medicine · doi:10.2169/internalmedicine.38.202 · Cited by 380 · see citing works
Self-citation
Genomic structure and mutations in adipose-specific gene, adiponectin
Takahashi, M., Arita, Y., Yamagata, K., Matsukawa, Y., Okutomi, K., Horie, M., Shimomura, I., Hotta, K., Kuriyama, H., Kihara, S., et al. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801244 · Cited by 374 · see citing works
Self-citation
Impact of anesthesia on cardiac function during echocardiography in mice
Roth, D. M., Swaney, J. S., Dalton, N. D., Gilpin, E. A., & ROSS, J. R. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00845.2001 · Cited by 351 · see citing works
Transgenic Mice Overexpressing Mutant PRKAG2 Define the Cause of Wolff-Parkinson-White Syndrome in Glycogen Storage Cardiomyopathy
Arad, M., Moskowitz, I. P. G., Patel, V. V., Ahmad, F., Pérez‐Atayde, A. R., Sawyer, D. B., Walter, M., Li, G. H., Burgon, P. G., Maguire, C. T., et al. (2003) · Circulation · doi:10.1161/01.cir.0000075270.13497.2b · Cited by 323 · see citing works
Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
Motoshima, H., Wu, X., Mahadev, K., & Goldstein, B. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.049 · Cited by 308 · see citing works
Increased Adenosine Monophosphate–Activated Protein Kinase Activity in Rat Hearts With Pressure-Overload Hypertrophy
Tian, R., Musi, N., D’Agostino, J., Hirshman, M. F., & Goodyear, L. J. (2001) · Circulation · doi:10.1161/hc4001.097183 · Cited by 308 · see citing works
Adiponectin gene expression is inhibited by β‐adrenergic stimulation via protein kinase A in 3T3‐L1 adipocytes
Faßhauer, M., Klein, J. C., Neumann, S., Eszlinger, M., & Paschke, R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02960-x · Cited by 263 · see citing works
Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo
Asakawa, M., Takano, H., Nagai, T., Uozumi, H., Hasegawa, H., Kubota, N., Saito, T., Masuda, Y., Kadowaki, T., & Komuro, I. (2002) · Circulation · doi:10.1161/hc1002.105225 · Cited by 255 · see citing works
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle
Li, J., Hu, X., Selvakumar, P., Russell, R. R., Cushman, S. W., Holman, G. D., & Young, L. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00234.2004 · Cited by 197 · see citing works
Renin-Angiotensin System and Angiotensin Receptor Blockers in the Metabolic Syndrome
Prasad, A., & Quyyumi, A. A. (2004) · Circulation · doi:10.1161/01.cir.0000141736.76561.78 · Cited by 178 · see citing works
Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure
Paolisso, G., Riu, S. D., Marrazzo, G., Verza, M., Varricchio, M., & D’Onofrio, F. (1991) · Metabolism · doi:10.1016/0026-0495(91)90075-8 · Cited by 174 · see citing works
Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)**The views expressed here are those of the authors and do not necessarily reflect those of the Indian Health Service.
Chinali, M., Devereux, R. B., Howard, B. V., Roman, M. J., Bella, J. N., Liu, J. E., Resnick, H. E., Lee, E. T., Best, L. G., & de Simone, G. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.009 · Cited by 157 · see citing works
Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: necropsy validation
Liao, Y., Ishikura, F., Beppu, S., Asakura, M., Takashima, S., Asanuma, H., Sanada, S., Kim, J., Ogita, H., Kuzuya, T., et al. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00238.2001 · Cited by 137 · see citing works
Self-citation
Activation of Adenosine A 1 Receptor Attenuates Cardiac Hypertrophy and Prevents Heart Failure in Murine Left Ventricular Pressure-Overload Model
Liao, Y., Takashima, S., Asano, Y., Asakura, M., Ogai, A., Shintani, Y., Minamino, T., Asanuma, H., Sanada, S., Kim, J., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000094744.88220.62 · Cited by 128 · see citing works
Self-citation
Left Ventricular Concentric Remodeling Rather Than Left Ventricular Hypertrophy Is Related to the Insulin Resistance Syndrome in Elderly Men
Sundström, J., Lind, L., Nyström, N., Zethelius, B., Andrén, B., Hales, C. N., & Lithell, H. (2000) · Circulation · doi:10.1161/01.cir.101.22.2595 · Cited by 124 · see citing works
Myocardial Ischemia Differentially Regulates LKB1 and an Alternate 5′-AMP-activated Protein Kinase Kinase
Altarejos, J. Y., Taniguchi, M., Clanachan, A. S., & Lopaschuk, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411810200 · Cited by 106 · see citing works
Insulin Signalling and Resistance in Patients with Chronic Heart Failure
Kemppainen, J., Tsuchida, H., Stolen, K. Q., Karlsson, H., Björnholm, M., Heinonen, O. J., Nuutila, P., Krook, A., Knuuti, J. M., & Zierath, J. R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042648 · Cited by 65 · see citing works
Long-Acting Ca 2+ Blockers Prevent Myocardial Remodeling Induced by Chronic NO Inhibition in Rats
Sanada, S., Node, K., Minamino, T., Takashima, S., Ogai, A., Asanuma, H., Ogita, H., Liao, Y., Asakura, M., Kim, J., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000062881.36813.7a · Cited by 63 · see citing works
Self-citation
Myocardial Wall Thickness and Left Ventricular Geometry in Hypertensives Relationship With Insulin
Paolisso, G. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00262-8 · Cited by 58 · see citing works
Celiprolol, A Vasodilatory β-Blocker, Inhibits Pressure Overload–Induced Cardiac Hypertrophy and Prevents the Transition to Heart Failure via Nitric Oxide–Dependent Mechanisms in Mice
Liao, Y., Asakura, M., Takashima, S., Ogai, A., Asano, Y., Shintani, Y., Minamino, T., Asanuma, H., Sanada, S., Kim, J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000137831.08683.e1 · Cited by 57 · see citing works
Self-citation
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
Russell, R. R., Li, J., Coven, D. L., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419297 · Cited by 57 · see citing works
Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism
Kantor, P. F., Robertson, M. A., Coe, J. Y., & Lopaschuk, G. D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00063-7 · Cited by 50 · see citing works
Impact of glucose intolerance and insulin resistance on cardiac structure and function. sex-related differences in the Framingham heart study
Rutter, M. K., Parise, H., & Benjamin, E. J. (2003) · ACC Current Journal Review · doi:10.1016/s1062-1458(03)00160-0 · Cited by 47 · see citing works
Benidipine, a long-acting calcium channel blocker, inhibits cardiac remodeling in pressure-overloaded mice
Liao, Y., Asakura, M., Takashima, S., Ogai, A., ASANO, Y., Asanuma, H., Minamino, T., Tomoike, H., Hori, M., & Kitakaze, M. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.006 · Cited by 44 · see citing works
Self-citation
812-1 C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the framingham offspring study
Rutter, M. K., Meigs, J. B., SULLIVAN, L. M., D’Agostino, R. B., & Wilson, P. W. F. (2004) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(04)92008-6 · Cited by 22 · see citing works
Left ventricular mass in type 2 diabetes mellitus. A study employing a simple ECG index: The Cornell voltage
de Kreutzenberg, S. V., Avogaro, A., Tiengo, A., & Prato, S. D. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343696 · Cited by 8 · see citing works

Flagged first, then by citations

Sorted by citations

Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Self-citation
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
Elumalai, A., & Jain, S. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061321 · Cited by 1,172 · see citing works
Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 883 · see citing works
Self-citation
Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease
Fuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 669 · see citing works
Self-citation
Adiponectin regulation and function
Fang, H., & Judd, R. L. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170046 · Cited by 631 · see citing works
Adipokines: A link between obesity and cardiovascular disease
Nakamura, K., Fuster, J. J., & Walsh, K. X. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.11.006 · Cited by 582 · see citing works
Metabolic Mechanisms in Heart Failure
Ashrafian, H., Frenneaux, M. P., & Opie, L. H. (2007) · Circulation · doi:10.1161/circulationaha.107.702795 · Cited by 517 · see citing works
AMPK alterations in cardiac physiology and pathology: enemy or ally?
Dyck, J. R. B., & Lopaschuk, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109389 · Cited by 386 · see citing works
Inflammation and fibrosis in murine models of heart failure
Bacmeister, L., Schwarzl, M., Warnke, S., Stoffers, B., Blankenberg, S., Westermann, D., & Lindner, D. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0722-5 · Cited by 384 · see citing works
AMP-Activated Protein Kinase in the Heart
Arad, M., Seidman, C. E., & Seidman, J. G. (2007) · Circulation Research · doi:10.1161/01.res.0000258446.23525.37 · Cited by 356 · see citing works
Adiponectin actions in the cardiovascular system
Hopkins, T. A., Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.009 · Cited by 326 · see citing works
Self-citation
Cardiac Energy Metabolism in Obesity
Lopaschuk, G. D., Folmes, C. D. L., & Stanley, W. C. (2007) · Circulation Research · doi:10.1161/circresaha.107.150417 · Cited by 302 · see citing works
AMPK as a mediator of hormonal signalling
Lim, C. T., Kola, B., & Korbonits, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0063 · Cited by 298 · see citing works
Metformin Prevents Progression of Heart Failure in Dogs
Sasaki, H., Asanuma, H., Fujita, M., Takahama, H., Wakeno, M., Ito, S., Ogai, A., Asakura, M., Kim, J., Minamino, T., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.798561 · Cited by 287 · see citing works
Self-citation
Leptin-Aldosterone-Neprilysin Axis: Identification of Its Distinctive Role in the Pathogenesis of the Three Phenotypes of Heart Failure in People With Obesity
Packer, M. (2018) · Circulation · doi:10.1161/circulationaha.117.032474 · Cited by 263 · see citing works
Cardioprotection by Adiponectin
Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.03.001 · Cited by 257 · see citing works
Self-citation
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity
Patel, V. B., Mori, J., McLean, B. A., Basu, R., Das, S. K., Ramprasath, T., Parajuli, N., Penninger, J. M., Grant, M. B., Lopaschuk, G. D., et al. (2015) · Diabetes · doi:10.2337/db15-0399 · Cited by 257 · see citing works
Natriuretic Peptides Enhance the Production of Adiponectin in Human Adipocytes and in Patients With Chronic Heart Failure
Tsukamoto, O., Fujita, M., Kato, M., Yamazaki, S., Asano, Y., Ogai, A., Okazaki, H., Asai, M., Nagamachi, Y., Maeda, N., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.038 · Cited by 251 · see citing works
Self-citation
AMP-activated protein kinase, stress responses and cardiovascular diseases
Wang, S., Song, P., & Zou, M. (2012) · Clinical Science · doi:10.1042/cs20110625 · Cited by 243 · see citing works
Activation and Inhibition of Sodium-Hydrogen Exchanger Is a Mechanism That Links the Pathophysiology and Treatment of Diabetes Mellitus With That of Heart Failure
Packer, M. (2017) · Circulation · doi:10.1161/circulationaha.117.030418 · Cited by 231 · see citing works
Adiponectin and Cardiovascular Disease
Shibata, R., Ouchi, N., & Murohara, T. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0057 · Cited by 214 · see citing works
Self-citation
Adiponectin protects against the development of systolic dysfunction following myocardial infarction
Shibata, R., Izumiya, Y., Sato, K., Papanicolaou, K. N., Kihara, S., Colucci, W. S., Sam, F., Ouchi, N., & Walsh, K. X. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.03.808 · Cited by 213 · see citing works
Self-citation
Murine Models of Heart Failure With Preserved Ejection Fraction
Valero‐Muñoz, M., Backman, W., & Sam, F. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.013 · Cited by 207 · see citing works
Expanding role of AMPK in endocrinology
Kola, B., Boscaro, M., Rutter, G. A., Grossman, A. B., & Korbonits, M. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.05.006 · Cited by 200 · see citing works
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
Beauloye, C., Bertrand, L., Horman, S., & Hue, L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr034 · Cited by 185 · see citing works
AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice
Zhang, P., Hu, X., Xu, X. Y., Fassett, J., Zhu, G., Viollet, B., Xu, W. W., Wiczer, B. M., Bernlohr, D., Bache, R. J., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114702 · Cited by 186 · see citing works
Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α
Fujita, K., Maeda, N., Sonoda, M., Ohashi, K., Hibuse, T., Nishizawa, H., Nishida, M., Hiuge, A., Kurata, A., Kihara, S., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156687 · Cited by 185 · see citing works
Self-citation
The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 190 · see citing works
Adipokines, Myokines and Cardiovascular Disease
Walsh, K. X. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0961 · Cited by 177 · see citing works
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease
Wong, A., Howie, J., Petrie, J. R., & Lang, C. C. (2009) · Clinical Science · doi:10.1042/cs20080066 · Cited by 164 · see citing works
Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
Viollet, B., Mounier, R., Leclerc, J., Yazigi, A., Foretz, M., & Andréelli, F. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.10.004 · Cited by 165 · see citing works
Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy
Guo, R., Zhang, Y., Turdi, S., & Ren, J. T. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.013 · Cited by 163 · see citing works
AMPK: A cellular metabolic and redox sensor. A minireview
Shirwany, N. A. (2014) · Frontiers in bioscience · doi:10.2741/4218 · Cited by 140 · see citing works
AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin
Wang, Y., Gao, E., Tao, L., Lau, W. B., Yuan, Y., Goldstein, B. J., Lopez, B. L., Christopher, T. A., Tian, R., Koch, W. J., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.815043 · Cited by 136 · see citing works
Adiponectin as a potential biomarker of vascular disease
Mohammadi, S., Arefhosseini, S. R., Ebrahimi‐Mameghani, M., Fallah, P., & Bazi, Z. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s48753 · Cited by 129 · see citing works
Role of adiponectin in the regulation of carbohydrate and lipid metabolism.
Karbowska, J., & Kochan, Z. (2006) · PubMed · Cited by 126 · see citing works
Adiponectin in Cardiovascular Inflammation and Obesity
Aprahamian, T. R., & Sam, F. (2011) · International Journal of Inflammation · doi:10.4061/2011/376909 · Cited by 122 · see citing works
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
Chakaroun, R., Olsson, L. M., & Bäckhed, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00771-0 · Cited by 122 · see citing works
Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance
Amin, R., Mathews, S. T., Camp, H. S., Ding, L., & Leff, T. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2009 · Cited by 118 · see citing works
Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart
Karmazyn, M., Purdham, D. M., Rajapurohitam, V., & Zeidan, A. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn115 · Cited by 118 · see citing works
Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes
PALANIVEL, R., FANG, X., PARK, M., EGUCHI, M., PALLAN, S., DEGIROLAMO, S., LIU, Y., WANG, Y., XU, A., & SWEENEY, G. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.011 · Cited by 117 · see citing works
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
Fang, X., Palanivel, R., Cresser, J., Schram, K., Ganguly, R., Thong, F. S. L., Tuinei, J., Xu, A., Abel, E. D., & Sweeney, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00086.2010 · Cited by 117 · see citing works
Adiponectin Regulation and Function
Fang, H., & Judd, R. L. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00036.x · Cited by 116 · see citing works
Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling
Essick, E. E., Ouchi, N., Wilson, R. M., Ohashi, K., Ghobrial, J. M., Shibata, R., Pimentel, D. R., & Sam, F. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00428.2011 · Cited by 110 · see citing works
Self-citation
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?
Elrakaybi, A., Laubner, K., Zhou, Q., Hug, M. J., & Seufert, J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101549 · Cited by 114 · see citing works
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
Shimano, M., Ouchi, N., Shibata, R., Ohashi, K., Pimentel, D. R., Murohara, T., & Walsh, K. X. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.021 · Cited by 109 · see citing works
Self-citation
Dietary supplementation with ω-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload
Duda, M. K., O’Shea, K. M., LEI, B., Barrows, B. R., Azimzadeh, A., McElfresh, T. A., Hoit, B. D., Kop, W. J., & Stanley, W. C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.07.002 · Cited by 105 · see citing works
Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways
Kang, S., Chemaly, E. R., Hajjar, R. J., & Lebeche, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200022 · Cited by 108 · see citing works
AMP-Activated Protein Kinase and Metabolic Control
Viollet, B., & Andréelli, F. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_13 · Cited by 106 · see citing works
Remodeling and Fibrosis of the Cardiac Muscle in the Course of Obesity—Pathogenesis and Involvement of the Extracellular Matrix
Kruszewska, J., Cudnoch‐Jędrzejewska, A., & Czarzasta, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084195 · Cited by 110 · see citing works
Adiponectin resistance in skeletal muscle: Pathophysiological implications in chronic heart failure
Sente, T., Van Berendoncks, A. M., Hoymans, V. Y., & Vrints, C. J. (2016) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12086 · Cited by 95 · see citing works
The Role of AMP-Activated Protein Kinase in Obesity
Kola, B., Grossman, A. B., & Korbonits, M. (2008) · KARGER eBooks · doi:10.1159/000115366 · Cited by 100 · see citing works
Adiponectin Action: A Combination of Endocrine and Autocrine/Paracrine Effects
Dadson, K., Liu, Y., & Sweeney, G. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00062 · Cited by 97 · see citing works
Macrophage Migration Inhibitory Factor Deletion Exacerbates Pressure Overload–Induced Cardiac Hypertrophy Through Mitigating Autophagy
Xu, X., Hua, Y., Nair, S., Bucala, R., & Ren, J. T. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02219 · Cited by 97 · see citing works
Metformin protects against doxorubicin-induced cardiotoxicity: Involvement of the adiponectin cardiac system
Lopez, M., Lax, A., Pascual-Figal, D. A., Valdés, M., & Sánchez‐Más, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.015 · Cited by 97 · see citing works
Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment
Shibata, R., Sato, K., Kumada, M., Izumiya, Y., Sonoda, M., Kihara, S., Ouchi, N., & Walsh, K. X. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.010 · Cited by 92 · see citing works
Self-citation
Adipocytokines, cardiovascular pathophysiology and myocardial protection
Smith, C., & Yellon, D. M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.003 · Cited by 90 · see citing works
Serum Adiponectin Level as an Independent Predictor of Mortality in Patients With Congestive Heart Failure
Tamura, T., Furukawa, Y., Taniguchi, R., Sato, Y., Ono, K., Horiuchi, H., Nakagawa, Y., Kita, T., & Kimura, T. (2007) · Circulation Journal · doi:10.1253/circj.71.623 · Cited by 91 · see citing works
Impact of a Single Intracoronary Administration of Adiponectin on Myocardial Ischemia/Reperfusion Injury in a Pig Model
Kondo, K., Shibata, R., Unno, K., Shimano, M., Ishii, M., Kito, T., Shintani, S., Walsh, K. X., Ouchi, N., & Murohara, T. (2010) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.109.872044 · Cited by 89 · see citing works
Self-citation
Metformin improves cardiac function in rats via activation of AMP‐activated protein kinase
Wang, X., Zhang, J., Li, L., Zhao, X., Tao, H., & Zhang, L. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05470.x · Cited by 89 · see citing works
Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy
Skurk, C., Wittchen, F., Suckau, L., Witt, H., Noutsias, M., Fechner, H., Schultheiss, H.-P., & Poller, W. C. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn136 · Cited by 86 · see citing works
Association of Hyperadiponectinemia With Severity of Ventricular Dysfunction in Congestive Heart Failure
Nakamura, T., Funayama, H., Kubo, N., Yasu, T., Kawakami, M., Saito, M., Momomura, S.-I., & Ishikawa, S.-E. (2006) · Circulation Journal · doi:10.1253/circj.70.1557 · Cited by 84 · see citing works
Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction
Varjabedian, L., Bourji, M., Pourafkari, L., & Nader, N. D. (2018) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-018-0266-3 · Cited by 83 · see citing works
Metformin action on AMP‐activated protein kinase: a translational research approach to understanding a potential new therapeutic target
Boyle, J. G., Salt, I. P., & McKay, G. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03098.x · Cited by 82 · see citing works
A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload
Raher, M. J., Thibault, H., Buys, E. S., Kuruppu, D., Shimizu, N., Brownell, A., Blake, S. L., Rieusset, J., Kaneki, M., Dérumeaux, G., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00139.2008 · Cited by 80 · see citing works
Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes
Liu, G., Ding, M., Chiuve, S. E., Rimm, E. B., Franks, P. W., Meigs, J. B., Hu, F. B., & Sun, Q. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308320 · Cited by 80 · see citing works
Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space
Rosa, S. C. D. S., Liu, M., & Sweeney, G. (2021) · Physiology · doi:10.1152/physiol.00031.2020 · Cited by 79 · see citing works
Direct effects of adipokines on the heart: focus on adiponectin
Park, M. S., & Sweeney, G. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9337-8 · Cited by 79 · see citing works
Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats
Guo, Z., Xia, Z., Yuen, V. G., & McNeill, J. H. (2007) · Metabolism · doi:10.1016/j.metabol.2007.05.005 · Cited by 76 · see citing works
AMPK isoform expression in the normal and failing hearts
Kim, M., Shen, M., Ngoy, S., Karamanlidis, G., Liao, R., & Tian, R. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.01.016 · Cited by 73 · see citing works
Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice
Sharma, A. X., Quittner-Strom, E. B., Lee, Y., Johnson, J. A., Martin, S. A., Yu, X., Li, J., Lu, J., Cai, Z. P., Chen, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.065 · Cited by 72 · see citing works
Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality
Molinaro, A., Nemet, I., Lassen, P. B., Chakaroun, R., Nielsen, T., Aron‐Wisnewsky, J., Bergh, P., Li, L., Henricsson, M., Køber, L., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.03.008 · Cited by 70 · see citing works
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
SHARMA, N., Okere, I. C., Duda, M. K., Chess, D. J., O’Shea, K. M., & Stanley, W. C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.007 · Cited by 69 · see citing works
Adipocytokines and obesity-linked disorders.
Ouchi, N., Ohashi, K., Shibata, R., & Murohara, T. (2012) · PubMed Central · doi:10.18999/nagjms.74.1-2.19 · Cited by 67 · see citing works
Self-citation
Relations of Circulating Resistin and Adiponectin and Cardiac Structure and Function: The Framingham Offspring Study
McManus, D. D., Lyass, A., Ingelsson, E., Massaro, J. M., Meigs, J. B., Aragam, J. R., Benjamin, E. J., & Vasan, R. S. (2011) · Obesity · doi:10.1038/oby.2011.32 · Cited by 68 · see citing works
Resistin, an adipocytokine, offers protection against acute myocardial infarction
Gao, J., Chua, C. C., Chen, Z., Wang, H., Xu, X., Hamdy, R. C., McMullen, J. R., Shioi, T., Izumo, S., & Chua, B. H. L. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.009 · Cited by 67 · see citing works
Metabolic Shifts during Aging and Pathology
Ma, Y., & Li, J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140041 · Cited by 73 · see citing works
Effects of Adiponectin on Calcium-Handling Proteins in Heart Failure With Preserved Ejection Fraction
Tanaka, K., Wilson, R. M., Essick, E. E., Duffen, J., Scherer, P. E., Ouchi, N., & Sam, F. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001279 · Cited by 67 · see citing works
Self-citation
Cardiometabolic effects of adiponectin
Parker, J., & Walsh, K. X. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.001 · Cited by 64 · see citing works
Diabetic cardiomyopathy: signaling defects and therapeutic approaches
Dobrin, J. S., & Lebeche, D. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.17 · Cited by 63 · see citing works
Adiponectin Level and Left Ventricular Hypertrophy in Japanese Men
Mitsuhashi, H., Yatsuya, H., Tamakoshi, K., Matsushita, K., Otsuka, R., Wada, K., Sugiura, K., Takefuji, S., Hotta, Y., Kondo, T., et al. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.079509 · Cited by 63 · see citing works
Adiponectin--an adipokine with unique metabolic properties
Wiecek, A., Adamczak, M., & Chudek, J. T. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl814 · Cited by 62 · see citing works
Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice
Takahashi, A., Asakura, M., Ito, S., Min, K.-D., Shindo, K., Yan, Y., Liao, Y., Yamazaki, S., Sanada, S., Asano, Y., et al. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00454.2012 · Cited by 61 · see citing works
Self-citation
Back to the heart: The protective role of adiponectin
Caselli, C., D’Amico, A., Cabiati, M., Prescimone, T., Ry, S. D., & Giannessi, D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.03.003 · Cited by 61 · see citing works
Insulin decreases myocardial adiponectin receptor 1 expression via PI3K/Akt and FoxO1 pathway
Cui, X., Wang, C., Li, L., Dong, F., Zhou, Y., Wu, D., Cui, Q., Fu, F.-Y., & Wu, L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr273 · Cited by 59 · see citing works
Usefulness of Adiponectin to Predict Myocardial Salvage Following Successful Reperfusion in Patients With Acute Myocardial Infarction
Shibata, R., Numaguchi, Y., Matsushita, K., Sone, T., Kubota, R., Ohashi, T., Ishii, M., Kihara, S., Walsh, K. X., Ouchi, N., et al. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.057 · Cited by 59 · see citing works
Self-citation
Circulating Adiponectin Levels in Patients With Atrial Fibrillation
Shimano, M., Shibata, R., Tsuji, Y., Kamiya, H., Uchikawa, T., Harata, S., Muto, M., Ouchi, N., Inden, Y., & Murohara, T. (2008) · Circulation Journal · doi:10.1253/circj.72.1120 · Cited by 58 · see citing works
Self-citation
Metabolic Disorders and Adipose Tissue Insulin Responsiveness in Neonatally STZ-Induced Diabetic Rats Are Improved by Long-Term Melatonin Treatment
de Oliveira, A. C., Andreotti, S., de Farias, T. D. S. M., Torres‐Leal, F. L., de Proença, A. R. G., Campaña, A. B., de Souza, A. H., Sertié, R. A. L., Carpinelli, Â. R., Cipolla‐Neto, J., et al. (2012) · Endocrinology · doi:10.1210/en.2011-1675 · Cited by 55 · see citing works
Obesity and Pulmonary Arterial Hypertension: Is Adiponectin the Molecular Link between these Conditions?
Summer, R. S., Walsh, K. X., & Medoff, B. D. (2011) · Pulmonary Circulation · doi:10.4103/2045-8932.93542 · Cited by 52 · see citing works
Adiponectin expression in patients with inflammatory cardiomyopathy indicates favourable outcome and inflammation control
Bobbert, P., Scheibenbogen, C., Jenke, A., Kania, G., Wilk, S., Krohn, S., Stehr, J., Kühl, U., Rauch, U., Eriksson, U., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq498 · Cited by 53 · see citing works
The cardio-protective signaling and mechanisms of adiponectin.
Nanayakkara, G., Kariharan, T., Wang, L., Zhong, J., & Amin, R. (2012) · PubMed Central · Cited by 51 · see citing works
G-Protein–Coupled Receptor Kinase 2–Mediated Desensitization of Adiponectin Receptor 1 in Failing Heart
Wang, Y., Gao, E., Lau, W. B., Wang, Y., Liu, G., Li, J., Wang, X., Yuan, Y., Koch, W. J., & Ma, X. (2015) · Circulation · doi:10.1161/circulationaha.114.015248 · Cited by 50 · see citing works
Effect of Atrial Natriuretic Peptide on Adiponectin in Patients with Heart Failure
Tanaka, T., Tsutamoto, T., Sakai, H., Nishiyama, K., Fujii, M., Yamamoto, T., & Horie, M. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.02.005 · Cited by 50 · see citing works
Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study
Reis, J. P., Allen, N. B., Gibbs, B. B., Gidding, S. S., Lee, J. M., Lewis, C. E., Lima, J. A. C., Lloyd‐Jones, D. M., Loria, C. M., Powell‐Wiley, T. M., et al. (2014) · Obesity · doi:10.1002/oby.20865 · Cited by 48 · see citing works
Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes
Bjornstad, P., Truong, U. T., Dorosz, J. L., Cree‐Green, M., Baumgartner, A., Coe, G. V., Pyle, L., Regensteiner, J. G., Reusch, J. E. B., & Nadeau, K. J. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002804 · Cited by 47 · see citing works
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload
Zhang, N., Wei, W., Liao, H.-H., Yang, Z., Hu, C., Wang, S., Deng, W., & Tang, Q. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1696-8 · Cited by 48 · see citing works
Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice
Suffee, N., Baptista, E., Piquereau, J., Ponnaiah, M., Doisne, N., Ichou, F., Lhomme, M., Pichard, C., Galand, V., Mougenot, N., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab367 · Cited by 47 · see citing works
Adiponectin and Risk of Congestive Heart Failure
Ingelsson, E., Risérus, U., Berne, C., Frystyk, J., Flyvbjerg, A., Axelsson, T., Lundmark, P., & Zethelius, B. (2006) · JAMA · doi:10.1001/jama.295.15.1772-c · Cited by 47 · see citing works
Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPARγ-dependent autocrine mechanism
Amin, R., Mathews, S. T., Alli, A., & Leff, T. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01032.2009 · Cited by 45 · see citing works

Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload
O’Shea, K. M., Chess, D. J., Khairallah, R. J., Rastogi, S., Hecker, P. A., Sabbah, H. N., Walsh, K. X., & Stanley, W. C. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00957.2009 · Cited by 31 · see citing works
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
Shimano, M., Ouchi, N., Shibata, R., Ohashi, K., Pimentel, D. R., Murohara, T., & Walsh, K. X. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.021 · Cited by 109 · see citing works
Self-citation
Adiponectin-mediated modulation of hypertrophic signals in the heart
Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671 · see citing works
Self-citation
Adiponectin Deficiency and Heart Failure
Funahashi, T. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.029
Self-citation
Adiponectin protects against the development of systolic dysfunction following myocardial infarction
Shibata, R., Izumiya, Y., Sato, K., Papanicolaou, K. N., Kihara, S., Colucci, W. S., Sam, F., Ouchi, N., & Walsh, K. X. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.03.808 · Cited by 213 · see citing works
Self-citation

Authors: LIAO, Y., TAKASHIMA, S., MAEDA, N., OUCHI, N., KOMAMURA, K., SHIMOMURA, I., HORI, M., MATSUZAWA, Y., FUNAHASHI, T., & KITAKAZE, M.
Affiliations: The University of Osaka (JP)
National Cerebral and Cardiovascular Center (JP)
Corresponding author: KITAKAZE, M
ORCID: LIAO, Y
TAKASHIMA, S
OUCHI, N
KOMAMURA, K
SHIMOMURA, I
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2005-09-01
Volume: 67
Issue: 4
Pages: 705-713
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/j.cardiores.2005.04.018
OpenAlex: W2148710672
Cited by: 236
References: 48
Citations by year: 2026: 1 · 2025: 6 · 2024: 1 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 15 · 2014: 13 · 2013: 10 · 2012: 16
FWCI: 13.45
Type: journal article
Language: en
Open access: closed
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, heart failure, AMPK, AMPKα, insulin resistance, glucose metabolism, cardiac hypertrophy, pressure overload, transverse aortic constriction, cardiac remodeling, adiponectin knockout mice, pulmonary congestion
MeSH terms: Adenylate Kinase, Animals, Blood Glucose, Echocardiography, Fasting, Heart Failure, Insulin, Insulin Resistance, Male, Myocardium, Blotting, Western, Mice, Knockout, Mice, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks