Comparison of right and left ventricular function in obese and nonobese men
Abstract
We studied systolic and diastolic function of the left and right ventricles in obese male subjects. Obese subjects had increased left ventricular mass and normal left ventricular systolic and diastolic function. They also had impaired right ventricular relaxation and right ventricular filling.
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Many published studies have concluded that obesity is independently associated with LV hypertrophy.
“Many published studies have concluded that obesity is independently associated with LV hypertrophy (22, 28, 63, 72, 116, 235, 242, 266, 279, 284, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [266]
Available published data do not consistently support the hypothesis that RV enlargement results from obstructive sleep apnea and chronic pulmonary hypertension.
“Although it seems likely that RV enlargement could result from obstructive sleep apnea and chronic pulmonary hypertension (see below), the available published data surprisingly do not consistently support this hypothesis (266, 378).”
From Cardiac remodeling in obesity (2008) · cites this paper as [266]
Some studies have found reduced early diastolic (E-wave) velocities while others have found them unchanged in obese subjects.
“Some studies have found reduced early diastolic (E-wave) velocities (155) while others have found them to be unchanged (242, 266, 274, 279, 314).”
From Cardiac remodeling in obesity (2008) · cites this paper as [266]
Findings on LV ejection fraction in obese subjects are variable, with studies reporting depressed, normal, or supernormal EF.
“Various authors have reported depressed LV ejection fraction (EF) (15, 68, 100), normal EF (22, 111, 116, 191, 242, 266, 279, 377), and supernormal EF (28, 155, 274, 375) in obese subjects.”
From Cardiac remodeling in obesity (2008) · cites this paper as [266]
One of these studies did find altered RV diastolic filling characteristics.
“However, one of these did find altered RV diastolic filling characteristics (266).”
From Cardiac remodeling in obesity (2008) · cites this paper as [266]
Late diastolic (A-wave) velocities have been reported to be increased or unchanged in obese subjects.
“Lastly, late diastolic (A-wave) velocities have been reported to be increased (28, 155, 242) or unchanged (266, 274, 279, 314).”
From Cardiac remodeling in obesity (2008) · cites this paper as [266]
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Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications
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- Authors
- Otto, M. E., Belohlavek, M., Khandheria, B., Gilman, G., Svatikova, A., & Somers, V.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Somers, Virend
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 93
- Issue
- 12
- Pages
- 1569-1572
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2070546020
- Cited by
- 80
- References
- 24
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 7
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 68555, HL65176, R01HL073211, R01HL065176, HL61560, HL73211, HL 70302, R01HL070302, R01HL068555, R01HL061560)
- National Center for Research Resources (M01-RR00 585, M01RR000585)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- obesity, right ventricular function, left ventricular function, left ventricular mass, systolic function, diastolic function, right ventricular filling, male subjects
- MeSH terms
- Adult, Blood Flow Velocity, Humans, Male, Middle Aged, Obesity, Respiration, Body Mass Index, Case-Control Studies, Ventricular Function, Left, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Right, Echocardiography, Doppler, Pulsed
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