Hemodynamic Mechanisms Underlying the Incomplete Tolerance to Caffeine's Pressor Effects
Abstract
Blood pressure (BP) and cardiovascular hemodynamics were assessed at baseline and after caffeine administration in a 4-week, placebo-controlled, double-blind, randomized, crossover trial of caffeine tolerance formation. Half of the subjects developed tolerance to the pressor effect of caffeine, whereas the other half continued to show increases in BP after caffeine ingestion (F = 16.7, p <0.0001). In the subjects who did not develop tolerance, peripheral resistance increased incrementally as the daily dose of caffeine increased (F = 2.8, p = 0.05).
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Some studies have shown that habitual consumption results in tolerance to the acute effects of caffeine, while others have found that some individuals continue to experience these acute effects with each drinking episode and that tolerance disappears after 12 hours of abstinence.
“Some studies have shown that habitual consumption results in a tolerance to the acute effects of caffeine, 18,19 while others have found that some individuals continue to experience these acute effects with each drinking episode 20,21 and that the tolerance disappears after 12 hours of abstinence.22”
From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [21]
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- Authors
- Farag, N. H., Vincent, A. S., McKey, B. S., Whitsett, T. L., & Lovallo, W. R.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Farag, Noha H.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 95
- Issue
- 11
- Pages
- 1389-1392
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2084966747
- Cited by
- 41
- References
- 18
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL32050, R01HL032050)
- National Center for Research Resources (M01 RR-14467, M01RR014467)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- caffeine, caffeine tolerance, pressor response, blood pressure, cardiovascular hemodynamics, systemic vascular resistance, dose-response relationship
- MeSH terms
- Adult, Blood Pressure, Caffeine, Double-Blind Method, Drug Tolerance, Female, Hemodynamics, Humans, Male, Vascular Resistance, Vasoconstrictor Agents, Cross-Over Studies
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