Circadian Variation of Endothelial Function in Idiopathic Dilated Cardiomyopathy
Abstract
This study measured flow-mediated dilation (FMD) of the brachial artery 3 times a day (6:30 a.m., 11:30 a.m., and 9 p.m.) in 7 normal subjects and 14 patients with idiopathic dilated cardiomyopathy (7 in New York Heart Association [NYHA] functional class I or II and 7 in NYHA functional class III or IV). FMD in normal subjects and patients in NYHA class I or II showed a circadian variation, being lowest in the morning and highest at night. Compared with them, FMD in patients in NYHA class III or IV was lower and almost constant during the day, showing loss of significant circadian variation in endothelial function in patients with congestive heart failure.
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In people with severe heart failure, endothelial function is impaired at all times, with loss of daily variation in endothelial function.
“Interestingly, in people with severe heart failure, endothelial function is impaired at all times, with loss of daily variation in endothelial function (128).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [128]
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- Authors
- Maruo, T., Nakatani, S., Kanzaki, H., Kakuchi, H., Yamagishi, M., Kitakaze, M., Ohe, T., & Miyatake, K.
- Affiliations
- Okayama University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Corresponding author
- Nakatani, Satoshi
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 97
- Issue
- 5
- Pages
- 699-702
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W1980182391
- Cited by
- 35
- References
- 21
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2014: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- idiopathic dilated cardiomyopathy, circadian variation, endothelial function, flow-mediated dilation, brachial artery, congestive heart failure, NYHA functional class, endothelial dysfunction
- MeSH terms
- Adult, Blood Flow Velocity, Brachial Artery, Cardiomyopathy, Dilated, Circadian Rhythm, Endothelium, Vascular, Female, Forearm, Nitroglycerin, Heart Rate, Humans, Male, Middle Aged, Atrial Natriuretic Factor, Regional Blood Flow, Stroke Volume, Vasodilation, Vasodilator Agents, Biomarkers, Case-Control Studies, Treatment Outcome, Natriuretic Peptide, Brain
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