Relation of Heart Rate Parameters During Exercise Test to Sudden Death and All-Cause Mortality in Asymptomatic Men
Open accessAbstract
Heart rate (HR) profile during exercise predicts all-cause mortality. However, less is known about its relation to sudden (vs nonsudden) death in asymptomatic people. The relation of exercise HR parameters (HR at rest, target HR achievement, HR increase, and HR recovery) with sudden death, coronary heart disease (CHD) death, myocardial infarction, and all-cause mortality was assessed in 12,555 men who participated in MRFIT. Subjects were 35 to 57 years old without clinical CHD, but with higher than average Framingham risk. Trial follow-up was 7 years, and extended follow-up after the trial for all-cause mortality was 25 years. After adjusting for cardiac risk factors, having to stop exercise before achieving 85% of age-specific maximal HR was associated with increased risk of sudden death (hazard ratio 1.8, 95% confidence interval [CI] 1.3 to 2.5, p = 0.001), CHD death (hazard ratio 1.4, 95% CI 1.2 to 1.5, p <0.001), and all-cause mortality (hazard ratio 1.3, 95% CI 1.2 to 1.4, p <0.001). Increased HR at rest (p = 0.001), attenuated HR increase (p = 0.02), delayed HR recovery (p = 0.04), and exercise duration (p <0.0001) were independent predictors of all-cause death in the overall study population and also in the subgroup that achieved target HR. In conclusion, middle-aged men without clinical CHD who stopped exercise before reaching 85% of maximal HR had a higher risk of sudden death. Other exercise HR parameters and exercise duration predicted all-cause mortality.
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The predictive value of various heart rate parameters during exercise tests and of ventricular conduction blocks and left anterior hemiblock were reconfirmed recently.
“The predictive value of various heart rate parameters during exercise tests 44 and of ventricular conduction blocks and left anterior hemiblock 45 were also reconfirmed recently.”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [44]
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The Year of 2008 in Electrocardiology
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- Authors
- Adabag, A. S., Grandits, G. A., Prineas, R. J., Crow, R. S., Bloomfield, H. E., & Neaton, J. D.
- Affiliations
- University of Minnesota (US)
- Wake Forest University (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 101
- Issue
- 10
- Pages
- 1437-1443
- ISSN
- 0002-9149 (ISSN-L)
- PMC
- PMC2440694
- OpenAlex
- W2097822166
- Cited by
- 85
- References
- 31
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 1 · 2013: 10 · 2012: 6
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL 68140, R01HL068140, R01HL043232)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- heart rate during exercise, exercise stress testing, sudden cardiac death, all-cause mortality, coronary heart disease mortality, myocardial infarction, asymptomatic men, maximal heart rate, heart rate recovery, heart rate increase, exercise duration
- MeSH terms
- Adult, Cause of Death, Coronary Disease, Exercise Test, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Time Factors, United States, Death, Sudden, Cardiac, Exercise Tolerance
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