Detrimental effects of energy drink consumption on platelet and endothelial function
Abstract
Background Energy drink consumption has been anecdotally linked with sudden cardiac death and, more recently, myocardial infarction. As myocardial infarction is strongly associated with both platelet and endothelial dysfunction, we tested the hypothesis that energy drink consumption alters platelet and endothelial function.Methods Fifty healthy volunteers (34 male, aged 22+/-2 years) participated in the study. Platelet aggregation and endothelial function were tested before, and 1 hour after, the consumption of 250 mL (1 can) of a sugar-free energy drink. Platelet function was assessed by adenosine diphosphate-induced (1 micromol/L) optical aggregometry in platelet-rich plasma. Endothelial function was assessed via changes in peripheral arterial tonometry and expressed as the reactive hyperemia index (RHI).Results Compared with baseline values, there was a significant increase in platelet aggregation following energy drink consumption, while no change was observed with control (13.7+/-3.7% vs 0.3+/-0.8% aggregation, respectively, P <.01). Similarly, RHI decreased following energy drink consumption (-0.33+/-0.13 vs 0.07+/-0.12 RHI [control], P <.05). Mean arterial pressure significantly increased following energy drink consumption, compared with control (P <.05). Heart rate was unaffected by energy drink consumption.Conclusion Energy drink consumption acutely increases platelet aggregation and decreases endothelial function in healthy young adults.
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A study of 50 young adults found that consuming a sugar-free energy drink containing 80 mg of caffeine was associated with changes in platelet and endothelial function great enough to increase the risk for severe cardiac events in susceptible individuals.
“a study of 50 young adults found that consuming a sugar-free energy drink containing 80 mg of caffeine (slightly less than the caffeine contained in one cup of coffee) was associated with changes in platelet and endothelial function great enough to increase the risk for severe cardiac events in susceptible individuals (193).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [193]
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- Authors
- Worthley, M. I., Prabhu, A., De Sciscio, P., Schultz, C., Sanders, P., & Willoughby, S. R.
- Affiliations
- Royal Adelaide Hospital (AU)
- Corresponding author
- Willoughby, Scott R.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 123
- Issue
- 2
- Pages
- 184-187
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2074640646
- Cited by
- 179
- References
- 15
- Citations by year
- 2026: 10 · 2025: 2 · 2024: 7 · 2023: 15 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 16 · 2014: 19 · 2013: 17 · 2012: 16
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- energy drinks, platelet aggregation, endothelial function, reactive hyperemia index, sudden cardiac death, myocardial infarction, mean arterial pressure, cardiovascular risk
- MeSH terms
- Central Nervous System Stimulants, Beverages, Caffeine, Endothelium, Vascular, Female, Glucuronates, Humans, Male, Platelet Aggregation, Taurine, Cohort Studies, Young Adult
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