Caffeine reduces myocardial blood flow during exercise

Higgins, John P.; Babu, Kavita M.

doi:10.1016/j.amjmed.2012.12.023

Cited by 86Coffee research and impactsThermoregulation and physiological responsesCardiovascular and exercise physiology

Caffeine reduces myocardial blood flow during exercise

Higgins, John P., Babu, Kavita M.·2013·The American Journal of Medicine

DOI 10.1016/j.amjmed.2012.12.023

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Abstract

Caffeine consumption has been receiving increased interest from both the medical and lay press, especially given the increased amounts now available in energy products. Acute ingestion of caffeine usually increases cardiac work; however, caffeine impairs the expected proportional increase in myocardial blood flow to match this increased work of the heart, most notably during exercise. This appears to be mainly due to caffeine's effect on blocking adenosine-induced vasodilatation in the coronary arteries in normal healthy subjects. This review summarizes the available medical literature specifically relating to pure caffeine tablet ingestion and reduced exercise coronary blood flow, and suggests possible mechanisms. Further studies are needed to evaluate this effect for other common caffeine-delivery systems, including coffee, energy beverages, and energy gels, which are often used for exercise performance enhancement, especially in teenagers and young athletes.

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Indirect laboratory measures indicate that caffeine consumed immediately before exercising substantially reduces myocardial blood flow in healthy individuals.
“Indirect laboratory measures indicate that caffeine consumed immediately before exercising substantially reduces myocardial blood flow in healthy individuals (114).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [114]

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Authors: Higgins, J. P., & Babu, K. M.
Affiliations: Memorial Hermann (US)
UMass Memorial Medical Center (US)
Corresponding author: Higgins, John P.
ORCID: Babu, Kavita M.
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 2013-08
Volume: 126
Issue: 8
Pages: 730.e1-730.e8
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/j.amjmed.2012.12.023
OpenAlex: W2043403655
Cited by: 85
References: 50
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 3
FWCI: 1.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: caffeine, myocardial blood flow, physical activity, coronary blood flow, adenosine, coronary vasodilation, energy gels, cardiac work, exercise performance enhancement, youth athletes
MeSH terms: Caffeine, Coronary Vessels, Heart, Hemodynamics, Humans, Phosphodiesterase Inhibitors, Exercise

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Caffeine reduces myocardial blood flow during exercise

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