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Cited by 26Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietBariatric Surgery and Outcomes

Incremental weight loss improves cardiometabolic risk in extremely obese adults

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Johnson, William D., Brashear, Meghan M., Gupta, Alok K., Rood, Jennifer C., Ryan, Donna H.·2011·The American Journal of Medicine
DOI 10.1016/j.amjmed.2011.04.033
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Abstract

Objective Excessively obese adults often acquire many metabolic disorders that put them at high risk for developing type 2 diabetes mellitus and cardiovascular disease. We investigated the hypothesis that cardiometabolic risk in a primary care cohort of 208 excessively obese adults (body mass index 40-60 kg/m(2), 48 with type 2 diabetes mellitus) would deteriorate with additional weight gain and improve incrementally beginning with 5% weight reduction.Methods Further analysis of the Louisiana Obese Subjects Study of excessively obese patients enrolled and followed during 2005-2008 is reported.Results Weight loss correlated significantly with improvements in fasting plasma glucose, triglycerides, high- and low-density lipoprotein cholesterol, uric acid, alanine aminotransferase, lactate dehydrogenase, and high-sensitivity C-reactive protein. Most parameters deteriorated with weight gain and progressively improved with 5% or more weight loss. Except for low-density lipoprotein cholesterol, all risk factors significantly improved with ≥ 20% loss of body weight. Among patients who had not been diagnosed with type 2 diabetes mellitus and had normoglycemia at baseline, median fasting plasma glucose increased significantly (13%) with stable or gained weight at 1 year, but did not change significantly with reduced weight. Although glucose levels did not change significantly in patients with type 2 diabetes mellitus who gained weight, a decline beginning after 5% weight reduction culminated in 25% glucose reduction with ≥ 20% weight loss. Resting blood pressure declined independently of weight change.Conclusion Very obese adults can improve their cardiometabolic risk under primary care weight management. Incremental success may help motivate further therapeutic weight reduction.

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Authors
Johnson, W. D., Brashear, M. M., Gupta, A. K., Rood, J. C., & Ryan, D. H.
Affiliations
Pennington Biomedical Research Center (US)
Corresponding author
Johnson, William D.
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2011-10
Volume
124
Issue
10
Pages
931-938
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/j.amjmed.2011.04.033
OpenAlex
W2101227890
Semantic Scholar
36a9c43ea9a67f1cc5e96dd559f3fd23afc3c6c5
Cited by
26
References
19
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2018: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
2.62
Type
journal article
Language
en
Open access
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
weight loss, cardiometabolic risk, type 2 diabetes, fasting blood glucose, lipid profile, uric acid, alanine aminotransferase, C-reactive protein, blood pressure, weight gain
MeSH terms
Adult, Aged, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Obesity, Obesity, Morbid, Weight Loss

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