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Intermittent Fasting: A Heart Healthy Dietary Pattern?
Open accessAbstract
Dietary patterns, such as the Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean diet, have been shown to improve cardiac health. Intermittent fasting is another type of popular dietary pattern that is based on timed periods of fasting. Two different regimens are alternative day fasting and time-restricted eating. Although there are no large, randomized control trials examining the relationship between intermittent fasting and cardiovascular outcomes, current human studies that suggest this diet could reduce the risk for cardiovascular disease with improvement in weight control, hypertension, dyslipidemia, and diabetes. Intermittent fasting may exert its effects through multiple pathways, including reducing oxidative stress, optimization of circadian rhythms, and ketogenesis. This review evaluates current literature regarding the potential cardiovascular benefits of intermittent fasting and proposes directions for future research.
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Metadata
- Authors
- Dong, T. A., Sandesara, P. B., Dhindsa, D. S., Mehta, A., Arneson, L. C., Dollar, A. L., Taub, P. R., & Sperling, L. S.
- Affiliations
- Emory University (US)
- Northwestern University (US)
- University of California San Diego (US)
- Corresponding author
- Sperling, Laurence S.
- ORCID
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 133
- Issue
- 8
- Pages
- 901-907
- ISSN
- 0002-9343 (ISSN-L)
- PMC
- PMC7415631
- OpenAlex
- W3018101566
- Cited by
- 240
- References
- 40
- Citations by year
- 2026: 14 · 2025: 43 · 2024: 50 · 2023: 44 · 2022: 38 · 2021: 47 · 2020: 4
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK118278)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Keywords
- intermittent fasting, cardiovascular disease, time-restricted eating, dietary habits, hypertension, dyslipidemia, diabetes mellitus, weight management, oxidative stress, circadian rhythm, ketogenesis
- MeSH terms
- Cardiovascular Diseases, Circadian Rhythm, Diabetes Mellitus, Fasting, Humans, Hypertension, Ketone Bodies, Obesity, Risk Factors, Oxidative Stress, Risk Reduction Behavior, Dyslipidemias, Diet, Ketogenic
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