Cited by 32Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studies

Gender-Related Differences in Gastroparesis

Gonzalez, Zorisadday, Loganathan, Priyadarshini, Sarosiek, Irene, McCallum, Richard W.·2020·The American Journal of the Medical Sciences

Abstract

Gastroparesis is a disorder where the stomach empties contents too slowly into the small intestine with associated symptoms of nausea, vomiting, postprandial fullness, bloating, early satiety and/or abdominal pain. It is a well-established fact that the female gender is more susceptible to developing gastroparesis compared to males, although the significance and rationale behind this gender inequality remains an unresolved mystery. Several hypotheses have been proposed including an intrinsically slower stomach in females, elevated levels of sex steroid hormones, loss of neuronal nitric oxide (nNOS) expression, and possibly due to altered serotonergic signaling. Recently, our group investigated gender-associated differences in the number of interstitial cells of Cajal in the antral and pyloric smooth muscle of diabetic patients with severe refractory gastroparesis and found there was no significant difference between the 2 genders. Targeting these gender-specific mechanisms may lead towards future therapeutic options that might alleviate and/or prevent gastroparesis. Furthermore, a better-understanding of the sex-related differences in gastroparesis can allow medical practitioners to better tailor treatment options for their patients. This article will attempt to explain why females are more vulnerable to developing gastroparesis by examining the pathogenesis and molecular basis of gender-related factors that have been identified to play a role in the gender disparity of this entity.

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Crossref · 10.1016/j.amjms.2020.04.018

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Authors
Gonzalez, Z., Loganathan, P., Sarosiek, I., & McCallum, R. W.
Affiliations
Texas Tech University Health Sciences Center (US)
Corresponding author
  • Gonzalez, Zorisadday
  • McCallum, Richard W.
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
2020-11
Volume
360
Issue
5
Pages
474-483
ISSN
0002-9629 (ISSN-L)
OpenAlex
W3017589319
Cited by
32
References
122
Citations by year
2026: 5 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 2
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Office of Faculty Development, Texas Tech University Health Sciences Center El Paso
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords
gastroparesis, sex differences, female susceptibility, diabetic gastroparesis, interstitial cells of Cajal, neuronal nitric oxide synthase, serotonergic signaling, sex hormones, gastric motility, pathogenesis
MeSH terms
Estrogens, Female, Gastric Emptying, Humans, Male, Nausea, Progesterone, Sex Characteristics, Vomiting, Gastroparesis

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