Cited by 252Seaweed-derived Bioactive CompoundsMicrobial Metabolites in Food BiotechnologyGut microbiota and health

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In vitro fermentation and prebiotic potential of novel low molecular weight polysaccharides derived from agar and alginate seaweeds

Ramnani, Priya, Chitarrari, Roberto, Tuohy, Kieran, Grant, John, Hotchkiss, Sarah, Philp, Kevin, Campbell, Ross, Gill, Chris, Rowland, Ian·2012·Anaerobe

DOI 10.1016/j.anaerobe.2011.08.003

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Abstract

Fermentation properties and prebiotic potential of novel low molecular weight polysaccharides (LMWPs) derived from agar and alginate bearing seaweeds was investigated. Ten LMWPs were supplemented to pH, temperature controlled anaerobic batch cultures inoculated with human feces from three donors, in triplicate. Microbiota changes were monitored using Fluorescent in-situ hybridization and short chain fatty acids, the fermentation end products were analysed using gas chromatography. Of the ten LMWPs tested, Gelidium seaweed CC2253 of molecular weight 64.64 KDa showed a significant increase in bifidobacterial populations from log(10) 8.06 at 0 h to log(10) 8.55 at 24 h (p = 0.018). For total bacterial populations, alginate powder CC2238 produced a significant increase from log(10) 9.01 at 0 h to log(10) 9.58 at 24 h (p = 0.032). No changes were observed in the other bacterial groups tested viz. Bacteroides, Lactobacilli/Enterococci, Eubacterium rectale/Clostridium coccoides and Clostridium histolyticum. The polysaccharides also showed significant increases in total SCFA production, particularly acetic and propionic acids, indicating that they were readily fermented. In conclusion, some LMWPs derived from agar and alginate bearing seaweeds were fermented by gut bacteria and exhibited potential to be used a novel source of prebiotics.

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Authors: Ramnani, P., Chitarrari, R., Tuohy, K., Grant, J., Hotchkiss, S., Philp, K., Campbell, R., Gill, C., & Rowland, I.
Affiliations: University of Reading (GB)
Fondazione Edmund Mach (IT)
CyberColloids (IE)
University of Ulster (GB)
Corresponding author: Ramnani, Priya
ORCID: Tuohy, Kieran
Gill, Chris
Rowland, Ian
Venue: Anaerobe
Publisher: Elsevier BV
Published: 2012-02
Volume: 18
Issue: 1
Pages: 1-6
ISSN: 1075-9964 (ISSN-L)
DOI: 10.1016/j.anaerobe.2011.08.003
OpenAlex: W2145123908
Cited by: 252
References: 32
Citations by year: 2026: 10 · 2025: 19 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 21 · 2020: 26 · 2019: 20 · 2018: 16 · 2017: 21 · 2016: 19 · 2015: 13 · 2014: 13 · 2013: 6 · 2012: 9
FWCI: 13.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Anaerobe (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutional Research Information System (Fondazione Edmund Mach) (submittedVersion)
Funders: European Commission
Research Executive Agency
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: low molecular weight polysaccharides, agar, alginate, seaweed, prebiotics, human fecal microbiota, short-chain fatty acids, Bifidobacterium, anaerobic batch culture, Gelidium, Bacteroides, Clostridium histolyticum
MeSH terms: Adult, Agar, Fatty Acids, Volatile, Feces, Female, Fermentation, Humans, Male, Molecular Weight, Polysaccharides, Seaweed, Time Factors, Gastrointestinal Tract, Metagenome, Prebiotics, Batch Cell Culture Techniques

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In vitro fermentation and prebiotic potential of novel low molecular weight polysaccharides derived from agar and alginate seaweeds

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