In vitro fermentation of sulfated polysaccharides from E. prolifera and L. japonica by human fecal microbiota
Abstract
In vitro fermentation of the sulfated polysaccharides from seaweeds Enteromorpha prolifera and Laminaria japonica and their prebiotic effects on human fecal microbiota were investigated in this study. The sulfated polysaccharides were fermented in vitro for 48h by human fecal cultures. When 0.8g MWCOL (polysaccharides MWCO<30kD) from L. japonica was fermented, the pH in fecal cultures decreased from 6.5 to 5.1 and the levels of short chain fatty acids, such as acetic, butyric and lactic acids all significantly increased. After 48h fermentation, 0.8g MWCOL showed good effect on modulating the gut microflora balance, because the beneficial strains (Lactobacillus and Bifidobacterium) were both significantly higher than those in control group (p<0.05). As far as we know, this is the first report that consumption of sulfated polysaccharides from E. prolifera and L. japonica is beneficial to the ecosystem of the intestinal tract by increasing the populations of probiotics and short chain fatty acids. Furthermore, our reports indicated that molecular weight of sulfated polysaccharide from marine algae is related to its prebiotic effects.
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Green algae Enteromorpha prolifera and Laminaria japonica can be fermented by intestinal microbiota.
“In turn, green algae, such as Enteromorpha prolifera and Laminaria japonica, spread all over the Chinese Qingdao coast, can also be fermented by intestinal microbiota [140].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [140]
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- Authors
- Kong, Q., Dong, S., Gao, J., & Jiang, C.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Kong, Qing
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 91
- Pages
- 867-871
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2425822924
- Cited by
- 126
- References
- 28
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 21 · 2023: 11 · 2022: 15 · 2021: 21 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 6
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shinan District Municipal Science and Technology Commision (2013-12-003-YY)
- National Natural Science Foundation of China (31471657)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- sulfated polysaccharides, Enteromorpha prolifera, Laminaria japonica, seaweed polysaccharides, prebiotic activity, human fecal microbiota, in vitro fermentation, short-chain fatty acids, gut microbiota modulation, Lactobacillus, Bifidobacterium, molecular weight, marine algae
- MeSH terms
- Bifidobacterium, Feces, Humans, Lactobacillus, Laminaria, Polysaccharides, Microbiota
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