Cited by 110Clostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders

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Detection of Clostridium perfringens toxin genes in the gut microbiota of autistic children

Finegold, Sydney M., Summanen, Paula H., Downes, Julia, Corbett, Karen, Komoriya, Tomoe·2017·Anaerobe

DOI 10.1016/j.anaerobe.2017.02.008

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Abstract

We studied stool specimens from 33 autistic children aged 2-9 years with gastrointestinal (GI) abnormalities and 13 control children without autism and without GI symptoms. We performed quantitative comparison of all Clostridium species and Clostridium perfringens strains from the fecal microbiota by conventional, selective anaerobic culture methods. We isolated C. perfringens strains and performed PCR analysis for the main C. perfringens toxin genes, alpha, beta, beta2, epsilon, iota and C. perfringens enterotoxin gene. Our results indicate that autistic subjects with gastrointestinal disease harbor statistically significantly (p = 0.031) higher counts of C. perfringens in their gut compared to control children. Autistic subjects also harbor statistically significantly (p = 0.015) higher counts of beta2-toxin gene-producing C. perfringens in their gut compared to control children, and the incidence of beta2-toxin gene-producing C. perfringens is significantly higher in autistic subjects compared to control children (p = 0.014). Alpha toxin gene was detected in all C. perfringens strains studied. C. perfringens enterotoxin gene was detected from three autistic and one control subject. Beta, epsilon, and iota toxin genes were not detected from autistic or control subjects.

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PREVALENCE, MOLECULAR CHARACTERIZATION AND THERAPEUTIC CONTROL OF CLOSTRIDIUM PERFRINGENS IN DIARRHEIC SHEEP AND GOATS
Hussain, K. (2018)

Authors: Finegold, S. M., Summanen, P. H., Downes, J., Corbett, K., & Komoriya, T.
Affiliations: University of California, Los Angeles (US)
VA West Los Angeles Medical Center (US)
Nihon University (JP)
Corresponding author: Finegold, Sydney M.
ORCID: Summanen, Paula H.
Corbett, Karen
Venue: Anaerobe
Publisher: Elsevier BV
Published: 2017-06
Volume: 45
Pages: 133-137
ISSN: 1075-9964 (ISSN-L)
DOI: 10.1016/j.anaerobe.2017.02.008
OpenAlex: W2587897382
Cited by: 110
References: 26
Citations by year: 2026: 3 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 16 · 2021: 16 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 3
FWCI: 9.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Anaerobe (publishedVersion)
PubMed (publishedVersion)
Funders: Autism Research Institute
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Clostridium perfringens, autism spectrum disorder, gut microbiota, toxin genes, beta2 toxin, alpha-toxin, enterotoxin, gastrointestinal anomalies, fecal microbiota, children
MeSH terms: Autistic Disorder, Bacterial Toxins, Bacteriological Techniques, Child, Child, Preschool, Clostridium perfringens, Feces, Female, Humans, Male, Polymerase Chain Reaction, Gastrointestinal Tract

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Detection of Clostridium perfringens toxin genes in the gut microbiota of autistic children

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