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Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies
Abstract
Purpose Chronic wounds are a major public health challenge, but little is known about the true burden with studies reporting different estimates because of disparities in study designs and measurement methods. This hampers efficient resource allocation, planning, and improvement of wound care. Methods Our study aimed to pool prevalence estimates from a global perspective by systematically carrying out searches in MEDLINE, EMBASE, Cochrane, CINAHL, Global Health, and PsycINFO databases for articles reporting the prevalence of chronic wounds in adults, from January 2000 to June 2018. The included publications had to define wound chronicity by duration (≥3 weeks), and/or labeling the wounds as chronic, complex, or hard-to-heal. Results Seventeen studies met the inclusion criteria, and 11 studies analyzing chronic wounds in the general population were included in random effects meta-analyses to calculate pooled prevalence. Chronic wounds of mixed etiologies (n = 3) showed a pooled prevalence of 2.21 per 1000 population, and for chronic leg ulcers (n = 9), the prevalence was estimated at 1.51 per 1000 population. Conclusions Our findings, aligned to previous studies reporting point prevalence of chronic wounds identified within the healthcare system, showed that the vast majority of chronic wounds in epidemiological studies are made up by chronic leg ulcers.
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“The lower extremity, which bears the body's weight and contains dense muscular tissue for this purpose, is the most common site of chronic wounds (1).”
From Multifactorial Insights into Chronic Leg Ulcers: Experience from a Tertiary Wound Care Center (2025) · cites this paper as [1]
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Klein, T. M., Andrees, V., Kirsten, N., Protz, K., Augustin, M., & Blome, C. (2021) · International Wound Journal · doi:10.1111/iwj.13533 · Cited by 73
The profile of patients with venous leg ulcers: a systematic review and global perspective
Gethin, G., Vellinga, A., Tawfick, W., O'Loughlin, A., McIntosh, C., Mac Gilchrist, C., Murphy, L., Ejiugwo, M., O'Regan, M., Cameron, A., et al. (2021) · Journal of Tissue Viability · doi:10.1016/j.jtv.2020.08.003 · Cited by 33
Borkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24
Multifactorial Insights into Chronic Leg Ulcers: Experience from a Tertiary Wound Care Center
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Metadata
- Authors
- Martinengo, L., Olsson, M., Bajpai, R., Soljak, M., Upton, Z., Schmidtchen, A., Car, J., & Järbrink, K.
- Venue
- Annals of Epidemiology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 29
- Pages
- 8-15
- ISSN
- 1047-2797
- Cited by
- 686
- References
- 8
- Language
- en
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- Martinengo, L., Olsson, M., Bajpai, R., Soljak, M., Upton, Z., Schmidtchen, A., Car, J., & Järbrink, K. (2019). Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies. Annals of Epidemiology. https://doi.org/10.1016/j.annepidem.2018.10.005