Cited by 291Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementTissue Engineering and Regenerative Medicine

Chronic wound repair and healing in older adults: current status and future research

Open access
Gould, Lisa, Abadir, Peter, Brem, Harold, Carter, Marissa, Conner‐Kerr, Teresa, Davidson, Jeff, DiPietro, Luisa, Falanga, Vincent +21 more·2015·Wound Repair and Regeneration

Abstract

The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age‐associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi‐morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection, and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The A ssociation of S pecialty P rofessors, in conjunction with the N ational I nstitute on A ging and the W ound H ealing S ociety, held a workshop, summarized in this paper, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify key research questions to guide future study of age‐associated changes in chronic wound healing.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/wrr.12245

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • GHK-treated aged mice find the escape hole significantly faster in trials 4 and 5 than saline-treated mice in a Box Maze spatial navigation task.

    “Mice treated with GHK were able to find the escape hole significantly faster in trials 4 and 5 compared to mice treated with saline (Figure 2) as assessed by a Box Maze spatial navigation learning task [27] at the end of the treatment period.”

    From The potential of GHK as an anti-aging peptide (2020) · cites this paper as [27]

    The cited paper’s Basic Science sections discuss wound healing in older mice, not a Box Maze spatial-navigation task. Searches for the Box Maze and for GHK-treated versus saline-treated mice found no passage addressing the task or the reported results for trials 4 and 5. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gould, L., Abadir, P., Brem, H., Carter, M., Conner‐Kerr, T., Davidson, J., DiPietro, L., Falanga, V., Fife, C., Gardner, S., Grice, E., Harmon, J., Hazzard, W. R., High, K. P., Houghton, P., Jacobson, N., Kirsner, R. S., Kovacs, E. J., Margolis, D., McFarland Horne, F., Reed, M. J., Sullivan, D. H., Thom, S., Tomic‐Canic, M., Walston, J., Whitney, J., Williams, J., Zieman, S., & Schmader, K.
Affiliations
  • Kent Hospital (US)
  • Johns Hopkins University (US)
  • Winthrop-University Hospital (US)
  • Strategic Solutions, Inc. Cody Wyoming
  • Winston-Salem State University (US)
  • Vanderbilt University (US)
  • University of Illinois Chicago (US)
  • Boston University (US)
  • Baylor College of Medicine (US)
  • University of Iowa (US)
  • University of Pennsylvania (US)
  • Wake Forest University Health Sciences (US)
  • Western University (CA)
  • Smith & Nephew Fort Worth Texas
  • University of Miami (US)
  • Loyola University Chicago (US)
  • Association of Specialty Professors Alexandria Virginia
  • University of Washington (US)
  • University of Arkansas for Medical Sciences (US)
  • University of Maryland, Baltimore (US)
  • National Institutes of Health (US)
  • Duke Medical Center (US)
Corresponding author
Gould, Lisa
Venue
Wound Repair and Regeneration
Publisher
Wiley
Published
2015-01
Volume
23
Issue
1
Pages
1-13
ISSN
  • 1067-1927 (ISSN-L)
  • 1524-475X
OpenAlex
W1791493718
Cited by
291
References
138
Citations by year
2026: 28 · 2025: 31 · 2024: 40 · 2023: 32 · 2022: 21 · 2021: 33 · 2020: 25 · 2019: 20 · 2018: 24 · 2017: 16 · 2016: 8 · 2015: 10 · 2014: 2
FWCI
11.65
Type
journal article
Language
en
Open access
Locations
  • Wound Repair and Regeneration (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • John A. Hartford Foundation
  • National Institute on Aging
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
chronic wounds, wound healing, aging, older adults, age-related changes, multimorbidity, quality of life, translational research, animal models, research priorities
MeSH terms
Administration, Topical, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Anti-Infective Agents, Canada, Chronic Disease, Electric Stimulation Therapy, Female, Humans, Male, Quality of Life, Skin Ulcer, United States, Wound Healing, Comorbidity, Disease Progression, Tissue Engineering, Mice, Negative-Pressure Wound Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review