Chronic wound repair and healing in older adults: current status and future research
Open accessAbstract
The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age‐associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi‐morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection, and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The A ssociation of S pecialty P rofessors, in conjunction with the N ational I nstitute on A ging and the W ound H ealing S ociety, held a workshop, summarized in this paper, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify key research questions to guide future study of age‐associated changes in chronic wound healing.
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GHK-treated aged mice find the escape hole significantly faster in trials 4 and 5 than saline-treated mice in a Box Maze spatial navigation task.
“Mice treated with GHK were able to find the escape hole significantly faster in trials 4 and 5 compared to mice treated with saline (Figure 2) as assessed by a Box Maze spatial navigation learning task [27] at the end of the treatment period.”
From The potential of GHK as an anti-aging peptide (2020) · cites this paper as [27]
The cited paper’s Basic Science sections discuss wound healing in older mice, not a Box Maze spatial-navigation task. Searches for the Box Maze and for GHK-treated versus saline-treated mice found no passage addressing the task or the reported results for trials 4 and 5. (LLM, conf=0.75)
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Age-associated skin conditions and diseases: Current perspectives and future options
Blume-Peytavi, U., Kottner, J., Sterry, W., Hodin, M. W., Griffiths, T. W., Watson, R. E. B., Hay, R. J., & Griffiths, C. E. M. (2016) · The Gerontologist · doi:10.1093/geront/gnw003 · Cited by 221 · see citing works
Wlaschek, M., Singh, K., Sindrilaru, A., Crisan, D., & Scharffetter-Kochanek, K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.036 · Cited by 76 · see citing works
“The incidence of chronic wounds increases with age [3] mainly due to a compromised immune system [61] and aging of the connective tissue including – among other cells [62–64] – a significant accumulation of senescent dermal fibroblasts [65].”
The potential of GHK as an anti-aging peptide
Department of Comparative Medicine, S. O. M., Dou, Y., Lee, A., Zhu, L., Morton, J., & Ladiges, W. (2020) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2020.03.014 · Cited by 33 · see citing works
“The ability of GHK and its Cu chelate to promote skin remodeling, wound healing and regeneration, and its prominent antioxidant and anti-inflammatory effects are qualities that will help enhance healthy aging [28-31].”
Background
- Authors
- Gould, L., Abadir, P., Brem, H., Carter, M., Conner‐Kerr, T., Davidson, J., DiPietro, L., Falanga, V., Fife, C., Gardner, S., Grice, E., Harmon, J., Hazzard, W. R., High, K. P., Houghton, P., Jacobson, N., Kirsner, R. S., Kovacs, E. J., Margolis, D., McFarland Horne, F., Reed, M. J., Sullivan, D. H., Thom, S., Tomic‐Canic, M., Walston, J., Whitney, J., Williams, J., Zieman, S., & Schmader, K.
- Affiliations
- Kent Hospital (US)
- Johns Hopkins University (US)
- Winthrop-University Hospital (US)
- Strategic Solutions, Inc. Cody Wyoming
- Winston-Salem State University (US)
- Vanderbilt University (US)
- University of Illinois Chicago (US)
- Boston University (US)
- Baylor College of Medicine (US)
- University of Iowa (US)
- University of Pennsylvania (US)
- Wake Forest University Health Sciences (US)
- Western University (CA)
- Smith & Nephew Fort Worth Texas
- University of Miami (US)
- Loyola University Chicago (US)
- Association of Specialty Professors Alexandria Virginia
- University of Washington (US)
- University of Arkansas for Medical Sciences (US)
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- Duke Medical Center (US)
- Corresponding author
- Gould, Lisa
- ORCID
- Gould, Lisa
- Abadir, Peter
- Carter, Marissa
- DiPietro, Luisa
- Falanga, Vincent
- Fife, Caroline
- Gardner, Sue
- Grice, Elizabeth
- Harmon, John
- Kirsner, Robert S.
- Kovacs, Elizabeth J.
- Margolis, David
- Reed, May J.
- Sullivan, Dennis H.
- Thom, Stephen
- Tomic‐Canic, Marjana
- Walston, Jeremy
- Whitney, JoAnne
- Williams, John
- Schmader, Kenneth
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 23
- Issue
- 1
- Pages
- 1-13
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- PMC
- PMC4414710
- OpenAlex
- W1791493718
- Cited by
- 291
- References
- 138
- Citations by year
- 2026: 28 · 2025: 31 · 2024: 40 · 2023: 32 · 2022: 21 · 2021: 33 · 2020: 25 · 2019: 20 · 2018: 24 · 2017: 16 · 2016: 8 · 2015: 10 · 2014: 2
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- John A. Hartford Foundation
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- chronic wounds, wound healing, aging, older adults, age-related changes, multimorbidity, quality of life, translational research, animal models, research priorities
- MeSH terms
- Administration, Topical, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Anti-Infective Agents, Canada, Chronic Disease, Electric Stimulation Therapy, Female, Humans, Male, Quality of Life, Skin Ulcer, United States, Wound Healing, Comorbidity, Disease Progression, Tissue Engineering, Mice, Negative-Pressure Wound Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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