The DOI matches its Crossref record; 142 of the 147 references it cites were found in a registry or an index; 48 of the 132 sources its claims cite were checked for support.
5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)
Open accessAbstract
For the purpose of advanced breast cancer (ABC) guidelines, ABC comprises both inoperable locally advanced breast cancer (LABC) and metastatic breast cancer (MBC).1,2 Advanced/metastatic breast cancer remains a virtually incurable disease, with a median overall survival (OS) of about 3 years and a 5-year survival rate of around 25%,3,4 even in countries without major accessibility problems. Survival is strongly related to breast cancer subtype, with the major advances seen in human epidermal growth factor receptor 2 (HER2)-positive ABC.
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Claims the paper makes
34 No full text of the sources · 18 Partly supported · 9 Supported · 5 Supported so far · 3 Own method · 1 Not checked yet · accuracy not yet measured
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“The last 2 years have seen the establishment of cyclin-dependent kinase (CDK)4/6 inhibitors combined with endocrine therapy (ET) as the standard of care for ER-positive/HER2-negative ABC”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [36] Im, 2019, Overall survival with ribociclib plus endocrine therapy in breast cancer, N Engl J Med source
- Partly supportedcites [37] Slamon, 2020, Overall survival with ribociclib plus fulvestrant in advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
The paper’s Abstract (page not supplied) says CDK4/6 inhibitors have improved outcomes in advanced breast cancer and that three are approved for hormone-receptor-positive, HER2-negative disease. The Discussion (page not supplied) says its findings may support considering ribociclib plus fulvestrant as initial therapy. These passages support the clinical role of the combination, but do not establish that CDK4/6 inhibitors plus endocrine therapy became the standard of care in the stated two-year period. (LLM, conf=0.82)
- Not checked — no full text of the sourcecites [38] Slamon, 2018, Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3, J Clin Oncol source
- Supportedcites [39] Sledge, 2019, The effect of abemaciclib plus fulvestrant on overall survival in hormone receptor-positive, erbb2-negative breast cancer that progressed on endocrine therapy-MONARCH 2: a randomized clinical trial, JAMA Oncol sourceExperimental — accuracy not yet measured
The paper’s introductory passage (labeled Abstract in our copy) says CDK4/6 inhibitors combined with endocrine therapy have emerged as standard-of-care treatment for HR-positive, HER2-negative advanced breast cancer. This supports the attributed standard-of-care claim. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [40] Sledge, 2017, MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2- advanced breast cancer who had progressed while receiving endocrine therapy, J Clin Oncol source
- Not checked — no full text of the sourcecites [41] Tripathy, 2018, Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial, Lancet Oncol source
- Not matchedcites [42] Tripathy, 2018, Cancer Res
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [43] Finn, 2016, Palbociclib and letrozole in advanced breast cancer, N Engl J Med source
- Partly supportedcites [44] Hortobagyi, 2016, Ribociclib as first-line therapy for HR-positive, advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
The Discussion reports longer progression-free survival with ribociclib plus letrozole than with letrozole alone in postmenopausal women receiving first-line treatment for HR-positive, HER2-negative advanced breast cancer. The paper supports the combination’s efficacy, but does not establish that CDK4/6 inhibitors as a class combined with endocrine therapy had become the standard of care. Its introduction instead identifies endocrine therapy as the standard of care at the time. (LLM, conf=0.87)
- Supportedcites [45] Rugo, 2019, Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up, Breast Cancer Res Treat sourceExperimental — accuracy not yet measured
The Discussion states that international guidelines recommend CDK4/6 inhibitors with endocrine therapy as first-line standard therapy for women with HR-positive/HER2-negative advanced breast cancer. The Introduction also describes this as a recent expansion of treatment guidelines. (LLM, conf=0.92)
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Ranges for survival scenarios are also more accurate than a single point estimate of expected survival.16 , 32 , 33”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [16] Smith-Uffen, 2020, Estimating survival in advanced cancer: a comparison of estimates made by oncologists and patients, Support Care Cancer source
- Supportedcites [32] Stockler, 2006, Disarming the guarded prognosis: predicting survival in newly referred patients with incurable cancer, Br J Cancer source
The Discussion recommends talking about survival in ranges rather than single point estimates because predictions were imprecise. The Results show that few patients’ actual survival times were close to their point predictions, supporting that recommendation for newly referred patients with incurable cancer. (LLM, conf=0.87)
- Supportedcites [33] Kiely, 2013, The median informs the message: accuracy of individualized scenarios for survival time based on oncologists' estimates, J Clin Oncol source
The Discussion states that point estimates of survival time were rarely accurate, whereas simple multiples of those estimates accurately described worst-case, typical, and best-case scenarios for patients with advanced cancer. It also explicitly says that providing three scenarios is more accurate than a single point estimate. (LLM, conf=0.94)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“in view of the OS benefit seen in several trials,36, 37, 38, 39, 40, 41, 42 both in the first- and second-line settings”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [36] Im, 2019, Overall survival with ribociclib plus endocrine therapy in breast cancer, N Engl J Med source
- Supportedcites [37] Slamon, 2020, Overall survival with ribociclib plus fulvestrant in advanced breast cancer, N Engl J Med source
The Overall Survival section reports favorable survival estimates with ribociclib plus fulvestrant in both the first-line subgroup and the subgroup receiving second-line therapy or experiencing early relapse. The Discussion says these findings support consideration as initial therapy and suggest benefit in the second-line or early-relapse subgroup. The subgroup estimates were not reported as independently statistically significant. (LLM, conf=0.86)
- Not checked — no full text of the sourcecites [38] Slamon, 2018, Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3, J Clin Oncol source
- Supportedcites [39] Sledge, 2019, The effect of abemaciclib plus fulvestrant on overall survival in hormone receptor-positive, erbb2-negative breast cancer that progressed on endocrine therapy-MONARCH 2: a randomized clinical trial, JAMA Oncol sourceExperimental — accuracy not yet measured
The Overall Survival section reports a statistically significant survival benefit with abemaciclib plus fulvestrant in HR-positive, ERBB2-negative advanced breast cancer. The Patients section includes women whose disease progressed after adjuvant endocrine therapy or during first-line endocrine therapy for advanced disease. This paper therefore supports its role as one of the trials cited for the broader statement; the sentence does not require every cited trial to establish a benefit in both settings individually. (LLM, conf=0.90)
- Not checked — no full text of the sourcecites [40] Sledge, 2017, MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2- advanced breast cancer who had progressed while receiving endocrine therapy, J Clin Oncol source
- Not checked — no full text of the sourcecites [41] Tripathy, 2018, Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial, Lancet Oncol source
- Not matchedcites [42] Tripathy, 2018, Cancer Res
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Most patients want considerably more information than many healthcare professionals expect, but the type and amount of information sought should be clarified.23”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [23] Jenkins, 2001, Information needs of patients with cancer: results from a large study in UK cancer centres, Br J Cancer source
The Discussion (page not provided) reports that 95% of surveyed patients wanted to know their chances of cure and says prognosis information should not be avoided. The paper also states that clinicians tend to underestimate patients’ information needs and recommends checking each patient’s preferences directly. (LLM, conf=0.90)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The study demonstrated a PFS benefit favouring the veliparib arm, with a median PFS of 14.5 versus 12.6 months (HR 0.71; 95% CI 0.57-0.88, P = 0.002)”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [79] Dieras, 2019, Phase 3 study of veliparib with carboplatin and paclitaxel in HER2-negative advanced/metastatic gBRCA-associated breast cancer, Ann Oncol source
The efficacy table in the Abstract (p. v857) reports investigator-assessed median PFS of 14.5 months with veliparib plus carboplatin/paclitaxel versus 12.6 months with placebo plus carboplatin/paclitaxel, with HR 0.71 (95% CI 0.57–0.88; P=0.002). The Conclusions also describe a significant PFS improvement. (LLM, conf=0.95)
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“an analysis was conducted and presented, and showed an OS of 25 months versus 15.1 months favouring the atezolizumab arm.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [68] Schmid, 2018, Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
The Interim Overall Survival Analysis reports median overall survival of 25.0 months with atezolizumab plus nab-paclitaxel versus 15.5 months with placebo plus nab-paclitaxel in the PD-L1-positive subgroup—not 15.1 months. It also says formal testing of overall survival in that subgroup was not conducted at this interim analysis. (LLM, conf=0.91)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“SP263 (Ventana) and 22-C3 (Dako), both of which are widely used in pathology laboratories for other tumour types, have been evaluated for their clinical validity in the context of the IMpassion-130 trial but failed to reproduce SP142 clinical validity.90”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [90] Rugo, 2019, Performance of PD-L1 immunohistochemistry (IHC) assays in unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC): post-hoc analysis of IMpassion130, Ann Oncol source
The Results and Conclusions (Annals of Oncology, p. v859) show that, at the evaluated cutoffs, 22C3 and SP263 identified more PD-L1-positive patients than SP142, while the SP142-positive population derived the greatest clinical benefit. This supports the claim that the other assays did not reproduce SP142’s clinical patient selection in the IMpassion130 analysis. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“these can be discontinued after 4 weeks as the risk of rash is primarily in the first 2 weeks of therapy.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [59] Nunnery, 2019, Management of toxicity to isoform α-specific PI3K inhibitors, Ann Oncol sourceExperimental — accuracy not yet measured
The Rash section (page unavailable) says alpelisib rash typically begins within the first two months of treatment. It does not establish that the risk is primarily confined to the first two weeks or recommend stopping prophylaxis after four weeks. (LLM, conf=0.82)
- Not checked — no full text of the sourcecites [60] Rugo, 2020, J Clin Oncol source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In the PIK3CA-mutated cohort, alpelisib provided a PFS benefit of 11.0 months versus 5.7 months [hazard ratio (HR) for progression or death: 0.65; 95% confidence interval (CI) 0.50-0.85, P < 0.001].”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [58] André, 2019, Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer, N Engl J Med source
The ‘Efficacy of Alpelisib-Fulvestrant in the Cohort with PIK3CA-Mutated Cancer’ section reports median progression-free survival of 11.0 months with alpelisib–fulvestrant versus 5.7 months with placebo–fulvestrant. It also gives the cited hazard ratio, confidence interval, and P value. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Only 20 patients (6%) in SOLAR-1 had been previously exposed to a CDK4/6 inhibitor.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [58] André, 2019, Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
Table 1 (Characteristics of the Patients at Baseline) reports prior CDK4/6 inhibitor treatment in 9 and 11 patients in the two PIK3CA-mutated groups: 20 of 341 patients, or about 6%. The claim omits that cohort restriction; across all four SOLAR-1 groups, the table reports 35 previously treated patients. (LLM, conf=0.88)
plainn = 20- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
- It may state two separate claims as one. 29
- Probably not a substantial claim. 8
- The quote only partly states this claim. 1
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Misunderstandings about prognosis are common16, 17, 18 and are associated with increased exposure to futile treatments.19, 20, 21, 22”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [16] Smith-Uffen, 2020, Estimating survival in advanced cancer: a comparison of estimates made by oncologists and patients, Support Care Cancer source
- Not checked — no full text of the sourcecites [17] Hagerty, 2005, Communicating prognosis in cancer care: a systematic review of the literature, Ann Oncol source
- Not checked — no full text of the sourcecites [18] Fried, 2003, Prognosis communication in serious illness: perceptions of older patients, caregivers, and clinicians, J Am Geriatr Soc source
- Partly supportedcites [19] Mack, 2012, Associations between end-of-life discussion characteristics and care received near death: a prospective cohort study, J Clin Oncol sourceExperimental — accuracy not yet measured
The Abstract reports that earlier end-of-life discussions were associated with less aggressive care in patients with stage IV lung or colorectal cancer. But the Discussion says the study did not assess discussion content, and its care measures could not distinguish beneficial from ineffective treatment. It therefore does not establish that misunderstandings about prognosis were associated with futile treatment. (LLM, conf=0.85)
- Partly supportedcites [20] Wright, 2008, Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment, JAMA sourceExperimental — accuracy not yet measured
The Discussion (page unavailable) says cancer patients frequently misunderstand or fail to recall prognostic discussions. The Results (Medical care at the end-of-life; page unavailable) associate reported end-of-life discussions with fewer aggressive interventions near death, but the study does not establish that prognostic misunderstandings themselves are associated with greater exposure to treatment, or characterize those treatments as futile. (LLM, conf=0.85)
- Not checked — no full text of the sourcecites [21] Weeks, 1998, Relationship between cancer patients' predictions of prognosis and their treatment preferences, JAMA source
- Not checked — no full text of the sourcecites [22] Pronzato, 1994, What do advanced cancer patients know of their disease? A report from Italy, Support Care Cancer source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“substantial PFS benefit and good toxicity profile.36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [36] Im, 2019, Overall survival with ribociclib plus endocrine therapy in breast cancer, N Engl J Med source
- Partly supportedcites [37] Slamon, 2020, Overall survival with ribociclib plus fulvestrant in advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
The Progression-free Survival section reports a substantial benefit for ribociclib plus fulvestrant over placebo plus fulvestrant in patients with advanced breast cancer. The Adverse Events section reports no new safety signals, but adverse events were more frequent with ribociclib, including grade 3 or 4 neutropenia in 57.1% versus 0.8%; it does not establish the claimed good toxicity profile. The trial also addresses this specific combination, not CDK4/6 inhibitors as a class. (LLM, conf=0.87)
- Not checked — no full text of the sourcecites [38] Slamon, 2018, Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3, J Clin Oncol source
- Partly supportedcites [39] Sledge, 2019, The effect of abemaciclib plus fulvestrant on overall survival in hormone receptor-positive, erbb2-negative breast cancer that progressed on endocrine therapy-MONARCH 2: a randomized clinical trial, JAMA Oncol sourceExperimental — accuracy not yet measured
In Other Exploratory End Points (page not provided), abemaciclib plus fulvestrant improved median PFS to 16.9 months versus 9.3 months with placebo plus fulvestrant. The Discussion (page not provided) describes its safety profile as generally tolerable and manageable. The paper supports these points for abemaciclib plus fulvestrant in the studied patients, but not for CDK4/6 inhibitors plus endocrine therapy as a class. (LLM, conf=0.85)
- Not checked — no full text of the sourcecites [40] Sledge, 2017, MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2- advanced breast cancer who had progressed while receiving endocrine therapy, J Clin Oncol source
- Not checked — no full text of the sourcecites [41] Tripathy, 2018, Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial, Lancet Oncol source
- Not matchedcites [42] Tripathy, 2018, Cancer Res
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [43] Finn, 2016, Palbociclib and letrozole in advanced breast cancer, N Engl J Med source
- Partly supportedcites [44] Hortobagyi, 2016, Ribociclib as first-line therapy for HR-positive, advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
The Discussion reports significantly longer progression-free survival with ribociclib plus letrozole and describes its adverse-event profile as acceptable for most patients. But this trial studied one CDK4/6 inhibitor with one endocrine therapy in postmenopausal women with HR-positive, HER2-negative advanced breast cancer; it does not establish the same benefit and toxicity profile for all CDK4/6 inhibitor–endocrine therapy combinations. (LLM, conf=0.86)
- Supportedcites [45] Rugo, 2019, Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up, Breast Cancer Res Treat source
The Discussion reports substantial PFS benefit from adding palbociclib to letrozole, and the Conclusions report improved PFS across clinically relevant subgroups. The Safety section reports no new safety signals with extended follow-up, although adverse events were more frequent than with placebo-letrozole. This paper supports the claim for palbociclib plus endocrine therapy in the studied breast-cancer setting. (LLM, conf=0.89)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Importantly, a reduction in the risk of CNS progression or death by 69% was observed in patients with stable brain metastases, while a confirmed objective response rate of 47% and a reduced risk of death by 51% were observed in patients with active brain metastases.63”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [63] Lin, 2020, Intracranial efficacy and survival with tucatinib plus trastuzumab and capecitabine for previously treated HER2-positive breast cancer with brain metastases in the HER2CLIMB trial, J Clin Oncol sourceExperimental — accuracy not yet measured
The Results sections for stable and active brain metastases report the 69% reduction in CNS progression or death and the 51% reduction in death, respectively. The Results also report a 47.3% confirmed intracranial response rate, but only among patients with active brain metastases who had measurable intracranial disease at baseline; the claim omits that restriction. (LLM, conf=0.86)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In the ITT population, there was no significant benefit in OS with the addition of atezolizumab; median OS was 21.3 months versus 17.6 months (HR 0.84; 95% CI 0.69-1.02, P = 0.08).”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [68] Schmid, 2018, Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer, N Engl J Med source
The Interim Overall Survival Analysis reports the first interim analysis in the intention-to-treat population: median overall survival was 21.3 months with atezolizumab plus nab-paclitaxel versus 17.6 months with placebo plus nab-paclitaxel, with HR 0.84, 95% CI 0.69–1.02, and P=0.08, explicitly marked not significant. The claim accurately describes that interim result. (LLM, conf=0.95)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“These agents can be combined with an aromatase inhibitor (AI) or fulvestrant, and are effective in de novo or recurrent ABC, in first or second line, in cases of primary or secondary resistance, in postmenopausal and premenopausal women (the latter with ovarian function suppression/ablation), and in men (preferably with a luteinising hormone-releasing hormone agonist).”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [36] Im, 2019, Overall survival with ribociclib plus endocrine therapy in breast cancer, N Engl J Med source
- Partly supportedcites [37] Slamon, 2020, Overall survival with ribociclib plus fulvestrant in advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
- Not checked — no full text of the sourcecites [38] Slamon, 2018, Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3, J Clin Oncol source
- Partly supportedcites [39] Sledge, 2019, The effect of abemaciclib plus fulvestrant on overall survival in hormone receptor-positive, erbb2-negative breast cancer that progressed on endocrine therapy-MONARCH 2: a randomized clinical trial, JAMA Oncol sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
- Not checked — no full text of the sourcecites [40] Sledge, 2017, MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2- advanced breast cancer who had progressed while receiving endocrine therapy, J Clin Oncol source
- Not checked — no full text of the sourcecites [41] Tripathy, 2018, Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial, Lancet Oncol source
- Not matchedcites [42] Tripathy, 2018, Cancer Res
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [43] Finn, 2016, Palbociclib and letrozole in advanced breast cancer, N Engl J Med source
- Partly supportedcites [44] Hortobagyi, 2016, Ribociclib as first-line therapy for HR-positive, advanced breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
- Partly supportedcites [45] Rugo, 2019, Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up, Breast Cancer Res Treat sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Trastuzumab deruxtecan was associated with a 13.6% risk of interstitial lung disease (ILD)/pneumonitis, fatal in 2.2% of cases, which needed appropriate and rapid diagnosis and treatment.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [64] Modi, 2020, Trastuzumab deruxtecan in previously treated HER2-positive breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
The Results > Safety passage reports ILD in 25 patients (13.6%) and four ILD-attributed deaths (2.2% of all treated patients). The claim's “fatal in 2.2% of cases” is imprecise: if “cases” means patients who developed ILD, the fatal proportion was four of 25, not 2.2%. The Discussion supports early detection and prompt intervention. (LLM, conf=0.86)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Thus, PD-L1 status by SP142 is the companion test for the use of atezolizumab in combination with a taxane for first-line therapy in triple-negative ABC, with a cut-off of 1% positive staining on immune cells.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [68] Schmid, 2018, Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
Trial Design and Procedures (page not provided) defines PD-L1 positivity as expression on tumor-infiltrating immune cells covering at least 1% of tumor area, and the Discussion reports first-line benefit with atezolizumab plus nab-paclitaxel. The paper does not establish SP142 as a companion test in its trial description; SP142 appears in a reference to a *complementary* diagnostic assay. The claim also broadens nab-paclitaxel to taxanes generally and describes the cutoff as 1% of immune cells staining positive rather than 1% of tumor area. (LLM, conf=0.88)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Trastuzumab deruxtecan (DS-8201), an ADC composed of trastuzumab, a cleavable tetrapeptide-based linker and a cytotoxic topoisomerase I inhibitor, demonstrated a response rate of 60.6% (95% CI 53.4-68.0) and an unprecedented median PFS of 16.4 months (95% CI 12.7—not reached) in a phase II study of heavily pretreated patients (median six lines, range 2-27 lines, including trastuzumab and T-DM1).64”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Partly supportedcites [64] Modi, 2020, Trastuzumab deruxtecan in previously treated HER2-positive breast cancer, N Engl J Med sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Toxicity was substantially increased in the alpelisib arm, especially hyperglycaemia, rash, gastrointestinal (GI) complaints (nausea, vomiting, loss of appetite, mucositis, diarrhoea) and fatigue, which lead to dose reductions/interruptions in around 70% of patients and discontinuations in 25%.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [58] André, 2019, Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer, N Engl J Med source
The Safety section reports higher rates of hyperglycemia, rash, diarrhea, nausea, and decreased appetite with alpelisib–fulvestrant, and 25.0% discontinued alpelisib because of adverse events. The adverse-event table also reports more vomiting, mucosal inflammation, and fatigue; the treatment passage reports dose interruptions in 74.0% and reductions in 63.9% of patients in the PIK3CA-mutated cohort. Page numbers were not provided in our copy. (LLM, conf=0.91)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Sleep disturbances may be treated with melatonin.122 , 123”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Supportedcites [122] Chen, 2014, A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes, Breast Cancer Res Treat source
The Discussion reports that melatonin improved sleep in a randomized trial of breast cancer survivors. It also describes evidence of efficacy for insomnia and other sleep problems, supporting the broader, hedged claim that melatonin may treat sleep disturbances. Page numbers were not provided in the supplied passages. (LLM, conf=0.94)
- Not checked — no full text of the sourcecites [123] Innominato, 2016, The effect of melatonin on sleep and quality of life in patients with advanced breast cancer, Support Care Cancer source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“For menopausal symptoms in general, mind-body interventions, physical training and cognitive behavioural therapy should be recommended as effective non-pharmacological treatment options.113, 114, 115, 116, 117”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [113] Duijts, 2012, Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial, J Clin Oncol source
- Partly supportedcites [114] Mann, 2012, Cognitive behavioural treatment for women who have menopausal symptoms after breast cancer treatment (MENOS 1): a randomised controlled trial, Lancet Oncol sourceExperimental — accuracy not yet measured
The Discussion (page unavailable) reports sustained benefits from CBT for hot flushes and night sweats in women after breast cancer treatment and calls it an effective treatment option for that group. It mentions only preliminary findings from a separate CBT-and-exercise trial; it does not establish physical training or mind-body interventions as independently effective, or extend its recommendation to menopausal symptoms in general. (LLM, conf=0.88)
- Partly supportedcites [115] Stefanopoulou, 2017, Mind-body interventions for vasomotor symptoms in healthy menopausal women and breast cancer survivors. A systematic review, J Psychosom Obstet Gynaecol sourceExperimental — accuracy not yet measured
The Conclusion (p. 15) supports recommending CBT for vasomotor symptoms and reports more consistent evidence for relaxation therapies. It also says evidence is insufficient to treat several other mind-body interventions as evidence-based options. The review does not establish physical training as effective, and its findings concern vasomotor symptoms rather than menopausal symptoms in general. (LLM, conf=0.90)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“there is evidence that some oncologists are overly optimistic about survival benefits from anticancer treatments while others are unduly nihilistic about the benefits of good quality supportive care.34”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [34] Fallowfield, 2017, Therapeutic aims of drugs offering only progression-free survival are misunderstood by patients, and oncologists may be overly optimistic about likely benefits, Support Care Cancer source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“For patients wanting quantitative information on life expectancy, providing ranges for worst-case, typical and best-case scenarios is more helpful and conveys more hope than providing a single point estimate of median survival.31”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [31] Kiely, 2013, Using scenarios to explain life expectancy in advanced cancer: attitudes of people with a cancer experience, Support Care Cancer source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“The available data show that bevacizumab combined with ChT as first-line therapy for ABC provides a moderate benefit in progression-free survival (PFS) and no benefit in OS.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [35] Hey, 2020, A systematic review and meta-analysis of bevacizumab in first-line metastatic breast cancer: lessons for research and regulatory enterprises, J Natl Cancer Inst source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The ESMO-MCBS v1.1 score for bevacizumab is two.35”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [35] Hey, 2020, A systematic review and meta-analysis of bevacizumab in first-line metastatic breast cancer: lessons for research and regulatory enterprises, J Natl Cancer Inst source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The quote only partly states this claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Although some physicians may avoid discussing prognosis for fear of upsetting the patient or destroying hope, there is no evidence that increased information about prognosis with sensitive communication is harmful to patients, or that it increases anxiety or distress.25, 26, 27, 28, 29, 30”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [25] Fallowfield, 2002, Truth may hurt but deceit hurts more: communication in palliative care, Palliat Med source
- Not checked — no full text of the sourcecites [26] Barnett, 2006, Does it hurt to know the worst?–psychological morbidity, information preferences and understanding of prognosis in patients with advanced cancer, Psychooncology source
- Not checked — no full text of the sourcecites [27] Enzinger, 2015, Outcomes of prognostic disclosure: associations with prognostic understanding, distress, and relationship with physician among patients with advanced cancer, J Clin Oncol source
- Not checked — no full text of the sourcecites [28] Gattellari, 2002, When the treatment goal is not cure: are cancer patients equipped to make informed decisions?, J Clin Oncol source
- Not checked — no full text of the sourcecites [29] Hagerty, 2005, Communicating with realism and hope: incurable cancer patients' views on the disclosure of prognosis, J Clin Oncol source
- Not checked — no full text of the sourcecites [30] Smith, 2010, Giving honest information to patients with advanced cancer maintains hope, Oncology (Williston Park)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Previous ABC recommendations that did not require update or only minor changes were not re-voted but were reviewed by all panel members by e-mail and remain valid.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Tucatinib, a highly selective inhibitor of the HER2 tyrosine kinase, used in combination with capecitabine and trastuzumab in a population of ABC patients pretreated with trastuzumab, pertuzumab and trastuzumab emtansine (T-DM1), demonstrated improvement of PFS (median 7.8 months versus 5.6 months, HR 0.54; 95% CI 0.42-0.71, P < 0.001) and OS (median 21.9 months versus 17.4 months, HR 0.66; 95% CI”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [62] Murthy, 2020, Tucatinib, trastuzumab, and capecitabine for HER2-positive metastatic breast cancer, N Engl J Med source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Furthermore, the NALA study has a severe limitation of not having a comparator arm with trastuzumab plus capecitabine, which was previously shown to provide superior OS to lapatinib plus capecitabine in the first- and second-line settings.67”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [67] Pivot, 2015, CEREBEL (EGF111438): a phase III, randomized, open-label study of lapatinib plus capecitabine versus trastuzumab plus capecitabine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer, J Clin Oncol source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Neratinib provided a small reduction in the risk of disease progression of 24% (95% CI 0.63-0.93; P = 0.006, medians not provided), a marginal difference in PFS and no impact on OS (co-primary end point) compared with lapatinib (both in combination with capecitabine), at the cost of increased toxicity.66”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [66] Saura, 2019, Neratinib + capecitabine versus lapatinib + capecitabine in patients with HER2+ metastatic breast cancer previously treated with ≥ 2 HER2-directed regimens: findings from the multinational, randomized, phase III NALA trial, J Clin Oncol source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“They may share morphological (high grade, poor differentiation)92 and biological features93 , 94 with TNBC and experience a similarly poor survival.95 , 96”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [92] Gloyeske, 2014, Low ER+ breast cancer: is this a distinct group?, Am J Clin Pathol source
- Not checked — no full text of the sourcecites [93] Deyarmin, 2013, Effect of ASCO/CAP guidelines for determining ER status on molecular subtype, Ann Surg Oncol source
- Not checked — no full text of the sourcecites [94] Iwamoto, 2012, Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry, J Clin Oncol source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All panel members were instructed to vote on all questions, and any members with a potential conflict of interest or who did not feel comfortable answering the question (e.g. due to lack of expertise in a particular field) were instructed to vote ‘abstain’.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Statements related to the management of side-effects and difficult symptoms, included under the supportive and palliative care section, were not voted on during the consensus session, but were discussed and unanimously agreed by e-mail, and are therefore considered to have 100% consensus agreement.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“This was achieved at the expense of increased toxicity, mostly diarrhoea and elevated aminotransferase levels of grade ≥3, but did not lead to frequent treatment discontinuation.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [62] Murthy, 2020, Tucatinib, trastuzumab, and capecitabine for HER2-positive metastatic breast cancer, N Engl J Med source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Margetuximab resulted in only a 0.9-month PFS prolongation (HR 0.76; 95% CI 0.59-0.98, P = 0.033) compared with trastuzumab (both combined with ChT of physician's choice), no OS benefit and a good toxicity profile.65”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [65] Rugo, 2019, SOPHIA primary analysis: a phase 3 (P3) study of margetuximab (M) + chemotherapy (C) versus trastuzumab (T) + C in patients (pts) with HER2+ metastatic (met) breast cancer (MBC) after prior anti-HER2 therapies (Tx), J Clin Oncol source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The overall response rate was 33.3% (95% CI 24.6-43.1), with a median duration of response of 7.7 months (95% CI 4.9-10.8).”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [72] Bardia, 2019, Sacituzumab govitecan-hziy in refractory metastatic triple-negative breast cancer, N Engl J Med source
plainn = 108- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Of the patients with a response to sacituzumab govitecan-hziy, 55.6% maintained their response for ≥6 months and 16.7% maintained their response for ≥12 months.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [72] Bardia, 2019, Sacituzumab govitecan-hziy in refractory metastatic triple-negative breast cancer, N Engl J Med source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Recently, these data were updated showing a PFS difference of 2.5 months and an OS difference of 7 months in the PD-L1-positive population.69”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [69] Schmid, 2020, Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial, Lancet Oncol source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“LMD carries a poor prognosis, with a median OS of approximately 4 weeks which can be prolonged to a few months in some patients with aggressive multimodal treatment.100”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [100] Franzoi, 2019, Leptomeningeal carcinomatosis in patients with breast cancer, Crit Rev Oncol Hematol source
plainconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Recently, the ASCO-College of American Pathologists (CAP) guidelines acknowledged that patients with tumours between 1% and 10% of ER staining represent a new reporting category, stipulating the lack of data concerning benefit from ET and the proximity to ER-negative breast cancer of this patient group.98”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [98] Allison, 2020, Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP Guideline update, J Clin Oncol source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“decreased or no interest in sexual activity was frequently reported with a significant association to less satisfaction and more discomfort (dyspareunia)”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [124] Mayer, 2019, Sexual activity and quality of life in patients after treatment for breast and ovarian cancer, Arch Gynecol Obstet source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“however, the lack of desire was not associated with global health status, QoL or the ability to experience orgasms”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [124] Mayer, 2019, Sexual activity and quality of life in patients after treatment for breast and ovarian cancer, Arch Gynecol Obstet source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Several organisations, such as ASCO,108 have been calling for measures to ensure adequate protection of cancer patients.”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [108] Page, 2019, Opioids and cancer pain: patients' needs and access challenges, J Oncol Pract source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Yet, in Europe and all over the world, there is inadequate and very unequal access to pain control,105”
§ 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) > Methodology
What the sources say
- Not checked — no full text of the sourcecites [105] Knaul, 2018, Alleviating the access abyss in palliative care and pain relief—an imperative of universal health coverage: the Lancet Commission report, Lancet source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The authors state this as an assumption.
The ABC 5 guidelines assume accessibility to all available therapies.
“assuming accessibility to all available therapies”
The paper relies on this without support.
Visceral crisis occurs in about 10-15% of first-line ABC cases.
“This situation is estimated to occur in only around 10%-15% of first-line ABC cases”
The paper relies on this without support.
No biomarkers currently enable accurate identification of patients who can be treated with endocrine therapy alone.
“There are currently no biomarkers to enable accurate identification of these patients.”
The paper relies on this without support.
There are no comparative data between the four new anti-HER2 agents (tucatinib, trastuzumab deruxtecan, margetuximab, neratinib).
“there are no comparative data between these four new anti-HER2 agents”
The paper relies on this without support.
The optimal sequence of treatments after trastuzumab, pertuzumab and T-DM1 is currently unknown.
“the question regarding the optimal sequence of treatments after trastuzumab, pertuzumab and T-DM1 is currently unknown.”
The paper relies on this without support.
Triple-negative advanced breast cancer is clinically and molecularly not one but many diseases.
“with the recognition that both clinically and molecularly this is not one but many diseases.”
The paper relies on this without support.
For most patients, chemotherapy remains the only available non-investigational systemic treatment option for non-BRCA-mutated triple-negative advanced breast cancer.
“For most patients, ChT remains the only available non-investigational systemic treatment option for non-BRCA-mutated triple-negative ABC”
The paper relies on this without support.
At present, only germline mutations in BRCA1/2 have clinical utility and therapeutic impact.
“However, at present, only germline mutations in BRCA1/2 have any clinical utility and therapeutic impact.”
The paper relies on this without support.
A mutation in another moderate- to high-penetrance gene has limited clinical implications in advanced breast cancer.
“a mutation in another moderate- to high-penetrance gene has limited clinical implications in the setting of ABC”
The paper relies on this without support.
The majority of PIK3CA mutations affect hot spots in exons 9 and 20.
“The majority of PIK3CA mutations affect hot spots i.e. the three most frequent in exons 9 and 20”
The paper relies on this without support.
PIK3CA mutations are present in up to 40% of metastatic luminal breast cancer.
“They are present in up to 40% of metastatic luminal breast cancer.”
The paper relies on this without support.
PIK3CA mutations activate the alpha isoform of PI3K and drive oncogenicity.
“The mutations activate the alpha isoform of PI3K and drive oncogenicity.”
The paper relies on this without support.
Acquisition of ESR1 mutations is frequent in advanced breast cancer patients previously treated with aromatase inhibitors (20%-40%) and is one mechanism of resistance to hormonal therapies.
“Acquisition of ESR1 mutations, frequent in ABC patients previously treated by AIs (20%-40%), is one of the mechanisms of resistance to hormonal therapies.”
The paper relies on this without support.
ESR1 mutations cause ligand-independent, constitutive activity of the estrogen receptor.
“The consequence is a ligand-independent, constitutive activity of ER.”
The paper relies on this without support.
Leptomeningeal disease is a rare complication of breast cancer with a 5% incidence rate.
“Leptomeningeal disease (LMD) is a rare complication of breast cancer with a 5% incidence rate.”
The paper relies on this without support.
Currently, there is no accepted standard of care for breast cancer leptomeningeal disease.
“Currently, there is no accepted standard of care for breast cancer LMD and recommendations are essentially expert opinion-based.”
The paper relies on this without support.
Many therapies for advanced breast cancer are associated with estrogen deprivation and patients often suffer from menopausal symptoms.
“Many therapies for ABC are associated with estrogen deprivation and patients often suffer from menopausal symptoms”
The paper relies on this without support.
Hormone replacement therapy is contraindicated due to the endocrine character of the disease.
“Hormone replacement therapy is contraindicated due to the endocrine character of the disease”
The paper relies on this without support.
Dyspareunia is often caused by vaginal dryness.
“Dyspareunia is often caused by vaginal dryness.”
The paper relies on this without support.
At first recurrence, one out of four patients is younger than 50 years old and premenopausal.
“At first recurrence, one out of four patients is younger than 50 years old and premenopausal.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The use of CDK4/6 inhibitors (ribociclib, abemaciclib, and palbociclib) improved progression-free survival in this patient population, leading to regulatory approvals. 9-13”
From Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer. (2022) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In patients with HR–positive and HER2–negative recurrent or metastatic breast cancer, endocrine therapy combined with CDK4/6 inhibitors has been established as the current standard of care.2)”
From Liver Resection after Disease Control with Abemaciclib for Solitary Liver Metastasis from Breast Cancer: A Case Report (2026) · cites this paper as [2]
The cited source says what the claim attributes to it.
In the citing paper
“As CDK4/6 inhibitor (CDK4/6i) + endocrine therapy (ET) is now a preferred option for 1L HR+/HER2− ABC”
In the citing paper
“Endocrine therapy is the backbone of systemic treatment for advanced hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer.1”
Citations
Cites
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · cited 25×
“Therefore, all ChT recommendations for HER2-negative disease also apply for triple-negative ABC.”
BackgroundInfluentialAtezolizumab and nab-paclitaxel in advanced triple-negative breast cancer
Schmid, P., Adams, S., Rugo, H. S., Schneeweiss, A., Barrios, C. H., Iwata, H., Diéras, V., Hegg, R., Im, S.-A., Shaw Wright, G., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1809615 · Cited by 4,350 · cited 2×
“Based on these data, atezolizumab in combination with nabpaclitaxel was approved and may be considered an option in the first-line setting for de novo advanced/metastatic disease or disease that has developed at least 12 months after completion of (neo)adjuvant ChT in tumours that have PD-L1 expression 1% based on sta…”
MethodSelf-citationOlaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation
Robson, M., Im, S.-A., Senkus, E., Xu, B., Domchek, S. M., Masuda, N., Delaloge, S., Li, W., Tung, N., Armstrong, A., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706450 · Cited by 3,294 · cited 1×
“02) in a subgroup analysis of predefined stratification subgroups,(75) lending further support to existing data for a PFS benefit with olaparib in the ITT population of the study.(76) The EMBRACA study(77) had a similar design to the OlympiAD study, comparing talazoparib with ChT monotherapy per physician’s choice (ca…”
ResultSelf-citationHarbeck, N., Penault-Llorca, F., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., Ruddy, K., Tsang, J., & Cardoso, F. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0111-2 · Cited by 3,024 · cited 2×
“Few (88) of these patients were treated in the CLEOPATRA trial and all with a trastuzumabfree interval >12 months.”
BackgroundSelf-citationPalbociclib and letrozole in advanced breast cancer
Finn, R. S., Martin, M., Rugo, H. S., Jones, S., Im, S.-A., Gelmon, K., Harbeck, N., Lipatov, O. N., Walshe, J. M., Moulder, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1607303 · Cited by 3,007 · cited 1×
“The last 2 years have seen the establishment of cyclindependent kinase (CDK)4/6 inhibitors combined with endocrine therapy (ET) as the standard of care for ER-positive/HER2-negative ABC in view of the OS benefit seen in several trials,(36-42) both in the first- and second-line settings, substantial PFS benefit and goo…”
BackgroundSelf-citationWright, A. A. (2008) · JAMA · doi:10.1001/jama.300.14.1665 · Cited by 2,788
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
André, F., Ciruelos, E., Rubovszky, G., Campone, M., Loibl, S., Rugo, H. S., Iwata, H., Conte, P., Mayer, I. A., Kaufman, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813904 · Cited by 2,622 · cited 2×
“The SOLAR-1 phase III, randomised, placebo-controlled trial evaluated the role of alpelisib, an oral inhibitor of the phosphoinositide 3-kinase alpha (PI3Ka) isoform, in combination with fulvestrant, for postmenopausal women andmenwhohad previously been treated with an AI.(58) In the PIK3CA-mutated cohort, alpelisib p…”
MethodInfluentialSelf-citationWolff, A. C., Hammond, M. E. H., Allison, K. H., Harvey, B. E., Mangu, P. B., Bartlett, J. M. S., Bilous, M., Ellis, I. O., Fitzgibbons, P. L., Hanna, W. M., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.77.8738 · Cited by 2,449 · cited 2×
“Tumours with staining of ER <1% and progesterone receptor (PgR)<1%andwithHER2-negative results by IHC and/ or in situ hybridisation are defined as TNBC.(91) Patients with a low (1%-10%) expression of hormone receptors and HER2negative account for 2%-3% of breast cancers.”
Liquid Biopsies: Genotyping Circulating Tumor DNA
Diaz, L. A., & Bardelli, A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2011 · Cited by 2,210 · cited 1×
“Different technologies are available from single-gene assay by quantitative polymerase chain reaction (qPCR) to whole genome sequencing by next-generation sequencing (NGS).(80,81) Standardisation is a critical point, especially for NGS-based analysis.”
MethodTalazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation
Litton, J. K., Rugo, H. S., Ettl, J., Hurvitz, S. A., Gonçalves, A., Lee, K.-H., Fehrenbacher, L., Yerushalmi, R., Mina, L. A., Martin, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1802905 · Cited by 2,175
Self-citation
Research works printed but not linked: 3
- Tripathy, 2018, Cancer Res, 78
- Juric, 2020, Cancer Res, 80
- 2019, Cannabis and cannabinoids, Med Lett Drugs Ther, 61, 179
Cited by
Sorted by citations
Items 301–400 of 1,367
Corti, C., & Criscitiello, C. (2021) · ESMO Open · doi:10.1016/j.esmoop.2021.100063 · Cited by 18
“Although the lack of comparative studies did not allow for recommendations about any specific sequencing, the development of novel anti-HER2 agents rapidly affected the field and shaped recent guidelines.(19) In this regard, the recently FDA-approved tucatinib-based combination represents a further valid choice, with…”
BackgroundStovgaard, E. S., Asleh, K., Riaz, N., Leung, S. C. Y., Gao, D., Nielsen, L. B., Lænkholm, A., Balslev, E., Jensen, M., Nielsen, D. L., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1924492 · Cited by 17
“CD8 sTILs count ≤30 vs >30 51 (22) 178 (78) 13 (18) 58 (82) 21 (26) 61 (74) 9 (27) 24 (73) 8 (19) 35 (81) 0.”
Pandey, K., Katuwal, N. B., Park, N., Hur, J., Cho, Y. B., Kim, S., Lee, S. A., Kim, I., Lee, S. R., & Moon, Y. W. (2022) · Cancers · doi:10.3390/cancers14010210 · Cited by 17
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“A prespecified sensitivity analysis was conducted to assess the impact on rwPFS and rwOS of the inclusion of patients for whom prior endocrine therapy for advanced disease was not undertaken neither had disease recurrence while on adjuvant endocrine therapy or within 12 months of its completion, initial palbociclib do…”
MethodRaheem, F., Ofori, H., Simpson, L., & Shah, V. S. (2022) · Annals of Pharmacotherapy · doi:10.1177/10600280211073322 · Cited by 18
Campone, M., Laurentiis, M. D., Zamagni, C., Kudryavcev, I., Agterof, M. J., Brown-Glaberman, U. A., Palácová, M., Chatterjee, S., Menon-Singh, L., Wu, J., et al. (2022) · Breast Cancer Research and Treatment · doi:10.1007/s10549-022-06543-1 · Cited by 17
Delineation of Pathogenomic Insights of Breast Cancer in Young Women
Paul, A. M., George, B., Saini, S., Pillai, M. R., Toi, M., Costa, L., & Kumar, R. (2022) · Cells · doi:10.3390/cells11121927 · Cited by 17
BAP18 facilitates CTCF-mediated chromatin accessible to regulate enhancer activity in breast cancer
Sun, G., Wei, Y., Zhou, B., Wang, M., Luan, R., Bai, Y., Li, H., Wang, S., Zheng, D., Wang, C., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01135-y · Cited by 18
“More than two-thirds of all breast cancers possess estrogen receptor alpha (ERα) positive and frequently respond to endocrine treatment, including tamoxifen, fulvestrant, and aromatase inhibitors (AI), which interfere with E2/ERα signaling [4, 5].”
BackgroundCardoso, F., McCartney, A., Ponti, A., Marotti, L., Vrieling, C., Eniu, A. E., Sousa, B., Ripamonti, C. I., Travado, L., Spitz, S., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2023.03.028 · Cited by 19
Self-citationEvolving perspectives on the treatment of HR+/HER2+ metastatic breast cancer
Pegram, M. D., Pietras, R. J., Dang, C. T., Murthy, R. K., Bachelot, T., Janni, W., Sharma, P., Hamilton, E. P., & Saura, C. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359231187201 · Cited by 20
Schmidt, G., Findeklee, S., Martinez, G. D. S., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13172811 · Cited by 17
Masiero, M. A., Spada, G. E., Sanchini, V., Munzone, E., Pietrobon, R. S., Teixeira, L., Valencia, M., Machiavelli, A., Fragale, E., Pezzolato, M., et al. (2023) · JMIR Research Protocols · doi:10.2196/48852 · Cited by 17
“The information contained in TREAT was constructed using the international guidelines for patients with MBC (eg, European School of Oncology-European Society for Medical Oncology 2nd international consensus guidelines for advanced breast cancer) [1,46].”
BackgroundMethodPalbociclib in Older Patients with Advanced/Metastatic Breast Cancer: A Systematic Review
Brain, E. G. C., Chen, C., Simon, S., Pasupuleti, V., Pfitzer, K. V., & Gelmon, K. A. (2024) · Targeted Oncology · doi:10.1007/s11523-024-01046-z · Cited by 20
Self-citationRugo, H. S., Schmid, P. E., Tolaney, S. M., Dalenc, F., Marmé, F., Shi, L., Verret, W. J., Shah, A., Gharaibeh, M., Bardia, A., et al. (2024) · The Oncologist · doi:10.1093/oncolo/oyae088 · Cited by 17
Self-citationLabrosse, J., Lecourt, A., Hours, A., Sebbag, C., Toussaint, A., Laas, E., Coussy, F., Grandal, B., Dumas, É., Daoud, E., et al. (2021) · Cancers · doi:10.3390/cancers13051070 · Cited by 16
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Olivier, T., & Prasad, V. K. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101248 · Cited by 17
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Ligorio, F., Zambelli, L., Fucà, G., Lobefaro, R., Santamaria, M., Zattarin, E., de Braud, F., & Vernieri, C. (2022) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221079123 · Cited by 20
Iwata, H., Nakamura, R., Masuda, N., Yamashita, T., Yamamoto, Y., Kobayashi, K., Tsurutani, J., Iwasa, T., Yonemori, K., Tamura, K., et al. (2022) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyac166 · Cited by 16
Cavalieri, S., Nuzzolese, I., Ottini, A., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1096068 · Cited by 16
“In fact, despite compelling evidence, in HER2 breast cancer, the upfront screening for CNS disease is currently not recommended, due to a lack of data supporting its benefit in terms of overall survival (25).”
BackgroundNagpal, A., Needham, K. A., Lane, D. J. R., Ayton, S., Redvers, R. P., John, M., Selistre-de-Araújo, H. S., Denoyer, D., & Pouliot, N. (2023) · Cancers · doi:10.3390/cancers15041216 · Cited by 16
Efficacy of CDK 4/6 Inhibitors and Radiotherapy in Breast Cancer Patients with Brain Metastases
Kubeczko, M., Jarząb, M., Krzywon, A., Gräupner, D., Polakiewicz-Gilowska, A., & Gabryś, D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12052044 · Cited by 18
“Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in combination with endocrine therapy are the standard of care approach in the first- or second-line setting for HR+/HER2− advanced breast cancer [5].”
BackgroundZhang, D., Lü, W., Zhuo, Z., Wang, Y., Zhang, W., & Zhang, M. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01511-0 · Cited by 17
Ionescu, A.-I., Atasiei, D.-I., Ionescu, R. T., Ultimescu, F., Barnonschi, A.-A., Anghel, A.-V., Anghel, C.-A., Antone-Iordache, I.-L., Mitre, R., Bobolocu, A. M., et al. (2024) · Cancers · doi:10.3390/cancers16020381 · Cited by 17
Rodon, J. A., Demanse, D., Rugo, H. S., Burris, H. A., Simó, R., Farooki, A., Wellons, M., André, F., Hu, H., Vuina, D., et al. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01773-1 · Cited by 17
“PIK3CA mutations are associated with poorer outcomes in metastatic breast cancer, promotion of tumor growth, and resistance to endocrine therapy (ET) [3, 5–7].”
BackgroundSelf-citationLiu, H., Zhang, J., Zhao, Y., et al. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23688 · Cited by 16
Yoshinami, T., Nagai, S. E., Hattori, M., Okamura, T., Watanabe, K., Nakayama, T., Masuda, H., Tsuneizumi, M., Takabatake, D., Harao, M., et al. (2024) · Breast Cancer · doi:10.1007/s12282-024-01575-5 · Cited by 17
Petit, T., Hajjaji, N., Antoine, É.-C., Benderra, M., Gozy, M., Foa, C., Mouysset, J., Grenier, J., Mousseau, M., Mailliez, A., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.7168 · Cited by 16
Observational Study of Men and Women with Breast Cancer in Terms of Overall Survival
Varzaru, V. B., Anastasiu-Popov, D. M., Eftenoiu, A.-E., Popescu, R., Vlad, D. C., Vlad, C. S., Moatar, A. E., Puscasiu, D. A., & Cobec, I. M. (2024) · Cancers · doi:10.3390/cancers16173049 · Cited by 16
“Some medical societies developed recommendations for the management of male breast cancer [2,20,21].”
BackgroundAdvances and challenges in the use of liquid biopsy in gynaecological oncology
Zhang, Y. X., & Tian, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39148 · Cited by 16
“These possibilities encompass the utilisation of targeted medicines in conjunction with other therapeutic approaches for patients who have advanced or recurring disease [332].”
BackgroundMolinelli, C., Bruzzone, M., Blondeaux, E., Ruelle, T., Lanzavecchia, C., Laurentiis, M. D., Russo, S., Riccardi, F., Sini, V., Cognetti, F., et al. (2024) · European Journal of Cancer · doi:10.1016/j.ejca.2024.115113 · Cited by 17
Harbeck, N., Brufsky, A., Rose, C. G., Korytowsky, B., Chen, C., Tantakoun, K., Jazexhi, E., Nguyen, D. H. V., Bartlett, M., Samjoo, I. A., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1530391 · Cited by 20
“Since their introduction, CDK4/6i plus ET have become the standard of care for fi rst-line treatment of HR+/HER2 − A/MBC, due to their ef fi cacy, safety, and maintenance of quality of life when used as fi rst-line treatment for patients with A/MBC (7 – 10).”
Self-citationLu, Y., Tong, Y., Chen, X., & Shen, K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638619 · Cited by 16
Tarantino, P., Antonarelli, G., Ascione, L., & Curigliano, G. (2021) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1972968 · Cited by 14
Self-citationShikanai, A., Horimoto, Y., Ishizuka, Y., Uomori, T., Nakai, K., Arakawa, A., & Saito, M. (2022) · Breast Cancer Basic and Clinical Research · doi:10.1177/11782234211065148 · Cited by 17
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Ji, Y., Schiller, H., Yang, S., Quinlan, M., Darstein, C., Huth, F., Winter, S., & Chakraborty, A. (2024) · Clinical Pharmacokinetics · doi:10.1007/s40262-023-01338-z · Cited by 17
“…as letrozole or anastro-zole, or selective estrogen receptor down-regulators such as fulvestrant) combined with an inhibitor of cyclin-dependent kinase 4 and/or 6 (CDK4/6), based on the National Comprehensive Cancer Network ® (NCCN ® ) and the European Society For Medical Oncology (ESMO) [8, 9].”
Czarnecka, A. M., Ostaszewski, K., Borkowska, A. M., Szumera‐Ciećkiewicz, A., Kozak, K., Świtaj, T., Rogala, P., Kalinowska, I., Koseła-Paterczyk, H., Zaborowski, K., et al. (2021) · Cancers · doi:10.3390/cancers14010110 · Cited by 15
Organ Manifestation and Systematic Organ Screening at the Onset of Inflammatory Rheumatic Diseases
Hoffmann, T., Oelzner, P., Busch, M., Franz, M., Teichgräber, U. K.-M., Kroegel, C., Schulze, P. C., Wolf, G., & Pfeil, A. (2021) · Diagnostics · doi:10.3390/diagnostics12010067 · Cited by 14
Hallermayr, A., Steinke‐Lange, V., Vogelsang, H., Rentsch, M., de Wit, M., Haberl, C., Holinski‐Feder, E., & Pickl, J. M. A. (2022) · Cancers · doi:10.3390/cancers14030851 · Cited by 15
“In certain clinical courses of patients with non-small cell lung cancer (NSCLC) and breast cancer, LB using ctDNA analysis is already recommended to guide therapeutic decisions [14,15], and is even covered by health insurance.”
BackgroundSurgical Management of Metastatic Breast Cancer: A Mini Review
Ueno, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.910544 · Cited by 15
Survival and prognostic factors in oligometastatic breast cancer
van Ommen‐Nijhof, A., Steenbruggen, T. G., Capel, L., et al. (2022) · The Breast · doi:10.1016/j.breast.2022.12.007 · Cited by 15
Ran, R., Ma, Y., Wang, H., Yang, J., & Jiao, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.975463 · Cited by 16
“Major guidelines recommend HER2-targeted therapy as the basis of treatment for HR+/HER2+ breast cancer in combination with chemotherapy or endocrine therapy, and the combination of drug regimens and how to select the appropriate population are the main concerns of clinical research (23).”
BackgroundKubeczko, M., Jarząb, M., Gabryś, D., et al. (2023) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2023.109839 · Cited by 15
Behrouzi, R., Armstrong, A. C., & Howell, S. J. (2023) · Breast Cancer Research and Treatment · doi:10.1007/s10549-023-07035-6 · Cited by 15
Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells
Heilala, M., Lehtonen, A. J., Arasalo, O., Peura, A., Pokki, J., Ikkala, O. T., Nonappa, N., Klefström, J. T., & Munne, P. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301137 · Cited by 17
Impact of cfDNA Reference Materials on Clinical Performance of Liquid Biopsy NGS Assays
Hallermayr, A., Keßler, T., Fujera, M., Liesfeld, B., Bernstein, S., von Ameln, S., Schanze, D., Steinke‐Lange, V., Pickl, J. M. A., Neuhann, T., et al. (2023) · Cancers · doi:10.3390/cancers15205024 · Cited by 15
Shao, Z., Cai, L., Wang, S., et al. (2024) · Discover Oncology · doi:10.1007/s12672-024-01027-8 · Cited by 15
Self-citationBrufsky, A., Kwan, M. L., Sandin, R., Stergiopoulos, S., Karanth, S. S., Cha-Silva, A. S., Makari, D., & Goyal, R. (2024) · Breast Cancer Research and Treatment · doi:10.1007/s10549-024-07469-6 · Cited by 15
“These regimens have now become the clinical guideline-recommended standard of care in patients with HR+/HER2− mBC [24–27].”
Kim, J., Oh, J. M., Park, Y. H., Ahn, J. S., & Im, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.759150 · Cited by 16
“The clinical values of these tumor markers are not well established but might be an aid to evaluate and monitor the response to treatment, particularly in patients with non-measurable metastatic disease with elevation of these markers (3).”
BackgroundInfluentialHer2-Positive Cancers and Antibody-Based Treatment: State of the Art and Future Developments
Morales, S. M., Gasol, A., & Guzman, D. R. S. (2021) · Cancers · doi:10.3390/cancers13225771 · Cited by 15
“With these data, the trastuzumab, pertuzumab, and taxane regimen were established as the standard first-line treatment in patients with HER2-positive MBC [49].”
MethodResultInfluentialΠαπαδάκος, Κ. Σ., Hagerling, C., Rydén, L., Larsson, A.-M., & Blom, A. M. (2021) · Cancers · doi:10.3390/cancers13235876 · Cited by 15
“These subgroups of advanced breast cancer patients (ER+ or HER2+) are treated nowadays with targeted systemic therapy as well as chemotherapy and have a better prognosis compared to patients with triple-negative disease [23].”
BackgroundMiglietta, F., Cinquini, M., Dieci, M. V., Cortesi, L., Criscitiello, C., Montemurro, F., Mastro, L. D., Zambelli, A., Biganzoli, L., Levaggi, A., et al. (2022) · The Breast · doi:10.1016/j.breast.2022.10.014 · Cited by 19
“[20] For patients with a germline BRCA mutation, single agent PARP”
BackgroundSelf-citationPyrotinib-based treatments in HER2-positive breast cancer patients with brain metastases
Ma, X., Li, Y., Li, L., Gao, C., Liu, D., Li, H., Zhao, Z., & Zhao, B. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2139411 · Cited by 15
Gastrointestinal Microbiota and Breast Cancer Chemotherapy Interactions: A Systematic Review
Csendes, D., Gutlapalli, S. D., Prakash, K., Swarnakari, K. M., Bai, M., Manoharan, M. P., Raja, R., Jamil, A., Desai, A., Desai, D. M., et al. (2022) · Cureus · doi:10.7759/cureus.31648 · Cited by 16
“Novel antibody-drug conjugates targeting ERBB2-low subtypes of advanced breast cancer, such as trastuzumab deruxtecan, have led to longer progression-free survival and overall survival compared to chemotherapy [3,6].”
BackgroundAmaral, C., Correia‐da‐Silva, G., Almeida, C. F., et al. (2023) · Molecules · doi:10.3390/molecules28020789 · Cited by 15
Management of vasomotor symptoms in cancer patients
Zhu, L., Hshieh, T. T., Iyer, T. K., Morgans, A. K., & Hamnvik, O. R. (2025) · The Oncologist · doi:10.1093/oncolo/oyaf002 · Cited by 19
Zebrafish Avatar testing preclinical study predicts chemotherapy response in breast cancer
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“In addition, European (ABC5) and American (NCCN) recommendations advise exhausting endocrine therapy lines before chemotherapy, again except in cases of rapid progression or endocrine resistance as defined by disease progression in the first 6 months of endocrine therapy for advanced disease [2,3].”
BackgroundPalmieri, C., Musson, A., Harper-Wynne, C. L., Wheatley, D. A., Bertelli, G., Macpherson, I. R., Nathan, M., McDowall, E., Bhojwani, A. A., Verrill, M. W., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02352-5 · Cited by 17
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“Endocrine therapy (ET) is highly effective in the treatment of hormone receptor-positive (HR + ), and human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) and currently is the preferred fi rst line treatment 1,2 .”
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“Despite advances in treatment, metastatic breast cancer (MBC) remains an incurable disease, with a 5-year survival rate of 25% and a median overall survival (OS) of 3 years (3).”
BackgroundDebbi, K., Benderra, M., Médioni, J., Durdux, C., To, N. H., Boukhobza, C., Grellier, N., Benmaziane, A., Monnier, L., Gligorov, J., et al. (2025) · The Breast · doi:10.1016/j.breast.2025.104421 · Cited by 15
“The standard treatment for newly diagnosed HER2-positive (HER2 + ) metastatic breast cancer is a combination of pertuzumab and trastuzumab (anti-HER2 antibodies) with taxanes [3 – 5].”
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“Although the use of antiandrogens is not recommended for routine clinical [11,12], some physicians nonetheless prescribe this treatment outside the context of a clinical trial.”
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Guideline for designing microbiome studies in neoplastic diseases
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“Hypertension 9 (15) 5 (8) 4 (7) 0 (0) 0 (0) Diarrhea 6 (10) 6 (10) 0 (0) 0 (0) 0 (0) Headache 8 (13) 7 (11) 1 (2) 0 (0) 0 (0) Peripheral sensory neuropathy 9 (15) 9 (15) 0 (0) 0 (0) 0 (0) Febrile neutropenia 5 (8) 1 (2) 4 (7) 0 (0) 0 (0) Cough 4 (7) 4 (7) 0 (0) 0 (0) 0 (0) Proteinuria 8 (13) 8 (13) 0 (0) 0 (0) 0 (0) T…”
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Metadata
- Authors
- Cardoso, F., Paluch-Shimon, S., Senkus, E., Curigliano, G., Aapro, M. S., André, F., Barrios, C. H., Bergh, J., Bhattacharyya, G. S., Biganzoli, L., Boyle, F., Cardoso, M.-J., Carey, L. A., Cortés, J., El Saghir, N. S., Elzayat, M., Eniu, A., Fallowfield, L., Francis, P. A., Gelmon, K., Gligorov, J., Haidinger, R., Harbeck, N., Hu, X., Kaufman, B., Kaur, R., Kiely, B. E., Kim, S.-B., Lin, N. U., Mertz, S. A., Neciosup, S., Offersen, B. V., Ohno, S., Pagani, O., Prat, A., Penault-Llorca, F., Rugo, H. S., Sledge, G. W., Thomssen, C., Vorobiof, D. A., Wiseman, T., Xu, B., Norton, L., Costa, A., & Winer, E. P.
- Affiliations
- Champalimaud Foundation (PT)
- Gdańsk Medical University (PL)
- University of Milan (IT)
- Clinique de Genolier (CH)
- Institut Gustave Roussy (FR)
- Latin American Cooperative Oncology Group (LACOG) (BR)
- Karolinska University Hospital (SE)
- Ospedale di Prato Santo Stefano (IT)
- Royal North Shore Hospital (AU)
- University of North Carolina at Chapel Hill (US)
- Vall d'Hebron Institute of Oncology (ES)
- Europa Donna (IT)
- Hôpital Riviera-Chablais (CH)
- Brighton and Sussex Medical School (GB)
- Peter MacCallum Cancer Centre (AU)
- BC Cancer Agency (CA)
- Sorbonne Université (FR)
- Ludwig-Maximilians-Universität München (DE)
- Fudan University (CN)
- Sheba Medical Center (IL)
- National Health and Medical Research Council (AU)
- Asan Medical Center (KR)
- Dana-Farber Cancer Institute (US)
- Metastatic Breast Cancer Network (US)
- Instituto Nacional de Enfermedades Neoplásicas (PE)
- Aarhus University Hospital (DK)
- The Cancer Institute Hospital (JP)
- University Hospital of Geneva (CH)
- Hospital Clínic de Barcelona (ES)
- Inserm (FR)
- University of California, San Francisco (US)
- Stanford Medicine (US)
- Martin Luther University Halle-Wittenberg (DE)
- Royal Marsden NHS Foundation Trust (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Memorial Sloan Kettering Cancer Center (US)
- European School of Oncology (CH)
- Corresponding author
- Cardoso, F.
- ORCID
- Cardoso, F.
- Senkus, E.
- Curigliano, G.
- Aapro, M.S.
- André, F.
- Bergh, J.
- Biganzoli, L.
- Boyle, F.
- Cardoso, M.-J.
- Carey, L.A.
- Cortés, J.
- Eniu, A.
- Fallowfield, L.
- Francis, P.A.
- Gelmon, K.
- Gligorov, J.
- Haidinger, R.
- Harbeck, N.
- Hu, X.
- Kaufman, B.
- Kiely, B.E.
- Lin, N.U.
- Neciosup, S.
- Ohno, S.
- Pagani, O.
- Prat, A.
- Penault-Llorca, F.
- Rugo, H.S.
- Sledge, G.W.
- Thomssen, C.
- Wiseman, T.
- Xu, B.
- Norton, L.
- Costa, A.
- Winer, E.P.
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 31
- Issue
- 12
- Pages
- 1623-1649
- ISSN
- 0923-7534 (ISSN-L)
- PMC
- PMC7510449
- OpenAlex
- W4206666777
- Cited by
- 1,369
- References
- 147
- Citations by year
- 2026: 151 · 2025: 182 · 2024: 238 · 2023: 276 · 2022: 293 · 2021: 210 · 2020: 18
- FWCI
- 68.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- HAL (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Minerva Access (University of Melbourne) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
- Funders
- ESMO
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Oncology › Advanced Breast Cancer Therapies
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Keywords
- advanced breast cancer, metastatic breast cancer, locally advanced breast cancer, treatment guidelines, HER2-positive breast cancer, breast cancer subtypes, overall survival
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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