The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Antiviral activities of type I interferons to SARS-CoV-2 infection
Open accessAbstract
There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces viral titers by 3.4 log or over 4 log, respectively, in Vero cells. The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. These results suggest that SARS-CoV-2 is more sensitive than many other human pathogenic viruses, including SARS-CoV. Overall, our results demonstrate the potential efficacy of human Type I IFN in suppressing SARS-CoV-2 infection, a finding which could inform future treatment options for COVID-19.
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Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19
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Cited by
Characteristics of SARS-CoV-2 and COVID-19
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Immunology of COVID-19: Current State of the Science
Vabret, N., Britton, G. J., Gruber, C., Hegde, S., Kim, J., Kuksin, M., Levantovsky, R., Malle, L., Moreira, A., Park, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.002 · Cited by 1,623
Activation and evasion of type I interferon responses by SARS-CoV-2
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Evasion of Type I Interferon by SARS-CoV-2
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Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19
Park, A., & Iwasaki, A. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.008 · Cited by 909
Metadata
- Authors
- Mantlo, E., Bukreyeva, N., Maruyama, J., Paessler, S., & Huang, C.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 179
- Pages
- 104811
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W3018221920
- Cited by
- 426
- References
- 31
- FWCI
- 27.10
- Type
- journal article
- Language
- en
- Open access
- green
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