Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer’s Disease in a Chinese Population
Abstract
Background and aims The association of polymorphism of circadian locomotor output cycle kaput (CLOCK) gene rs 4580704 C/G with susceptibility of Alzheimer's disease (AD) was examined in the present study.Methods This was a case/control study and investigated the association of polymorphism of CLOCK gene rs 4580704 C/G with susceptibility of AD. Genotypes of apolipoprotein E (APOE) and CLOCK gene rs 4580704 C/G were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) detection method.Results This study was comprised of 296 unrelated AD patients and 423 controls. We performed an analysis the association of polymorphism of CLOCK gene rs 4580704 C/G with susceptibility of AD. In the whole sample or APOEε4 noncarriers, prevalence of C carriers in CLOCK gene rs 4580704 in AD patients was significantly higher than in controls (in the whole sample: χ(2) = 13.773, p <0.0001; in APOEε4 noncarriers: χ(2) = 51.588, p <0.0001). However, among APOEε4 carriers, prevalence of C carriers in CLOCK gene rs 4580704 between patients and controls was not statistically significant (χ(2) = 0.753, p = 0.386).Conclusions Among APOEε4 noncarriers, C carriers in CLOCK gene rs 4580704 were associated with a high susceptibility of AD; however, among APOEε4 carriers the functional polymorphism of clock gene rs 4580704 C/G was not associated with AD susceptibility.
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SNPs in CLOCK and BMAL1, and in BMAL1 and PER1, are associated with increased risk of Alzheimer disease and Parkinson disease, respectively.
“the incidence of single-nucleotide polymorphisms (SNPs) in CLOCK and BMAL1, and in BMAL1 and PER1, are associated with increased risk of Alzheimer disease (AD) and Parkinson disease (PD), respectively251–253”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [251]
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- Authors
- Chen, H.-F., Huang, C.-Q., You, C., Wang, Z.-R., & Si-qing, H.
- Affiliations
- Sichuan University (CN)
- Mianyang Third People's Hospital (CN)
- ORCID
- You, Chao
- Venue
- Archives of Medical Research
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 44
- Issue
- 3
- Pages
- 203-207
- ISSN
- 0066-6769 (ISSN-L)
- 0188-4409
- OpenAlex
- W2023097326
- Cited by
- 48
- References
- 29
- Citations by year
- 2025: 4 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 3
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sichuan Province Science and Technology Support Program
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- Alzheimer's disease, clock genes, single nucleotide polymorphisms, genetic susceptibility, APOE ε4 carriers, circadian rhythm, Chinese population
- MeSH terms
- Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Female, Genotype, Humans, Male, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Case-Control Studies, Polymerase Chain Reaction, Genetic Predisposition to Disease, Asian People, CLOCK Proteins
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