The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Current understanding of klotho
Open accessAbstract
Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress. Klotho functions as a cofactor/coreceptor regulating fibroblast growth factor (FGF) 23 signaling. Klotho acts as a glucuronidase and activates ion channel TRPV5. Klotho protects against endothelial dysfunction and regulates the production of nitric oxide. Klotho also influences intracellular signaling pathways including p53/p21, cAMP, protein kinase C (PKC) and Wnt signaling pathways. The discovery of klotho has a great impact on aging research. The purpose of this review is to provide the recent progress and future directions of klotho research. Specifically, this review will cover: klotho and aging, structure and expression of the klotho gene, localization of klotho expression, source of circulating klotho, current understanding of klotho functions, and signaling pathways of klotho.
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Cites
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“Vascular endothelium has been known to play a crucial role in the control of vascular tone; endothelial cells release nitric oxide (NO) in response to specific agonists such as acetylcholine (Griffith et al., 1984; Palmer et al., 1987).”
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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“Transient or irreversible p53-mediated cell cycle arrest in the transition from the G1 to S phase of cell replication is mediated by the transcriptional activation of the cyclin dependent kinase (CDK) inhibitors such as p16 and p21 (Campisi, 2005).”
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
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Suppression of Aging in Mice by the Hormone Klotho
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Augmented Wnt signaling in a mammalian model of accelerated aging
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Cited by
Aging, Arterial Stiffness, and Hypertension
Sun, Z. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.03617 · Cited by 594
Self-citationMolecular Basis of Klotho: From Gene to Function in Aging
Xu, Y., & Sun, Z. (2015) · Endocrine Reviews · doi:10.1210/er.2013-1079 · Cited by 549
Self-citationRole of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders
Workgroup, O. B. O. T. E. R. O. (., Carrillo-López, N., Martínez-Arias, L., Fernández-Villabrille, S., Ruiz-Torres, M. P., Dusso, A., Cannata-Andía, J. B., Naves-Díaz, M., & Panizo, S. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00803-2 · Cited by 91
Klotho: An Elephant in Aging Research
Cheikhi, A., Barchowsky, A., Sahu, A., Shinde, S. N., Pius, A., Clemens, Z. J., Li, H., Kennedy, C. A., Hoeck, J. D., Franti, M., et al. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz061 · Cited by 92
Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity
Ullah, M., & Sun, Z. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly261 · Cited by 77
Self-citation
Metadata
- Authors
- Wang, Y., & Sun, Z.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 8
- Issue
- 1
- Pages
- 43-51
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2085105325
- Cited by
- 327
- References
- 12
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- green
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