Tau protein kinases: Involvement in Alzheimer's disease

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Items 301–400 of 646

1. Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
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2. Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice
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3. From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis
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4. Design, synthesis and biological evaluation of furan based α-aminophosphonate derivatives as anti-Alzheimer agent
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5. Function and regulation of cis P‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies
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6. The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein
   Haoling Qi, Clément Despres, Sudhakaran Prabakaran, François‐Xavier Cantrelle, Béatrice Chambraud, Jeremy Gunawardena, Guy M. Lippens, Caroline Smet‐Nocca, Isabelle Landrieu · 2016 · Methods in molecular biology
7. Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
   Yuta Takaichi, James Kenn CHAMBERS, Hiroyuki Inoue, Yasuhisa Ano, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida · 2020 · Acta Neuropathologica Communications
8. Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
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9. Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons
   Daniel Li, Veronica Musante, Wen‐Liang Zhou, Marina R. Picciotto, Angus Clark Nairn · 2018 · Journal of Biological Chemistry
10. Targeting tau in Alzheimer’s and beyond: Insights into pathology and therapeutic strategies
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11. Recent advances in molecularly imprinted polymers toward biomedical healthcare devices
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12. Tau acetylation at K280 regulates tau phosphorylation
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13. Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer’s Disease-Related Biomarkers
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14. Discovery of effective GSK-3β inhibitors as therapeutic potential against Alzheimer's disease: A computational drug design insight
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15. Contributive Role of Hyperglycemia and Hypoglycemia Towards the Development of Alzheimer’s Disease
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16. Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors
    Digambar Kumar Waiker, Chandrabose Karthikeyan, Vasanthanathan Poongavanam, Jacob Kongsted, Olivier Lozach, Laurent Meijer, Piyush Trivedi · 2014 · Bioorganic & Medicinal Chemistry
17. Natural products against tau hyperphosphorylation‐induced aggregates: Potential therapies for Alzheimer's disease
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18. Plexin-A4 mediates amyloid-β–induced tau pathology in Alzheimer’s disease animal model
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19. A Review: Meridianins and Meridianins Derivatives
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20. Aspergillus in Biomedical Research
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21. Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease
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22. Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer’s Disease
    Yuewen Chen, Jinying Xu, Xiaopu Zhou, Saijuan Liu, Yulin Zhang, Shuangshuang Ma, Amy K.Y. Fu, Nancy Y. Ip, Yu Chen · 2019 · ACS Chemical Neuroscience
23. Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer’s disease
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24. Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases
    Laura Llorach-Parés, Alfons Nonell‐Canals, Conxita Àvila, Melchor Sánchez-Martínez · 2022 · Marine Drugs
25. Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases
    Damien Hédou, Julien Godeau, Nadège Loaëc, Laurent Meijer, Corinne Fruit, Thierry Besson · 2016 · Molecules
26. Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies
    Yoori Choi, Seunggyun Ha, Yun‐Sang Lee, Yun Kyung Kim, Dong Soo Lee, Dong Jin Kim · 2017 · Nuclear Medicine and Molecular Imaging
27. Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
    Mohammad Amir Mishan, Mozhgan Rezaei Kanavi, Koorosh Shahpasand, Hamid Ahmadieh · 2019 · Journal of Ophthalmic and Vision Research
28. Beneficial Effects of Sideritis scardica and Cichorium spinosum against Amyloidogenic Pathway and Tau Misprocessing in Alzheimer’s Disease Neuronal Cell Culture Models
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29. Phosphorylation and Dephosphorylation of Tau Protein by the Catalytic Subunit of PKA, as Probed by Electrophoretic Mobility Retard
    María José Benítez, Raquel Cuadros, Juan S. Jiménez · 2020 · Journal of Alzheimer s Disease
30. Flavonoids as Promising Multitarget Agents in Alzheimer’s Disease Therapy
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31. Effect of arctigenin on neurological diseases: A review
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32. Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease
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33. Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices
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34. Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3β Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
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35. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons
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36. Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling
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37. Lithium in Medicine: Mechanisms of Action
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38. A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease
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39. Abnormal phosphorylation of protein tyrosine in neurodegenerative diseases
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40. A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer’s disease (AD)
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41. Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors
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42. Drugs for Targeted Therapies of Alzheimer’s Disease
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43. Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model
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44. Sulfotransferase 2B1b, Sterol Sulfonation, and Disease
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45. Three-way interaction model to trace the mechanisms involved in Alzheimer’s disease transgenic mice
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46. Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer’s disease model mice
    Katherine R. Sadleir, Karen Gómez, Abigail E. Edwards, Armana J. Patel, Makenna L. Ley, Ammaarah W. Khatri, Joanna Guo, Shreya Mahesh, Elyse A. Watkins, Jelena Popović et al. · 2025 · Acta Neuropathologica
47. American Ginseng for the Treatment of Alzheimer’s Disease: A Review
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48. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure
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49. Influence of Tau on Neurotoxicity and Cerebral Vasculature Impairment Associated with Alzheimer’s Disease
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50. Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer's disease
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51. Unravelling the potency of 4,5-diamino-4 H -1,2,4 triazole-3-thiol derivatives for kinase inhibition using a rational approach
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52. Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia
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53. Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity
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54. Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy
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55. Arsenic and Tau Phosphorylation: A Mechanistic Review
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56. Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease
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57. HMGCS2-Induced Autophagic Degradation of Tau Involves Ketone Body and ANKRD24
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58. Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer’s Disease–Related Epitopes and Increases Intraneuronal Tau Levels
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59. Glaucocalyxin A as a natural product increases amyloid β clearance and decreases tau phosphorylation involving the mammalian target of rapamycin signaling pathway
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60. Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo
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61. Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats
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62. Effects of altered tau expression on dentate granule cell excitability in mice
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63. cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus
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65. Long‐term exposure to excessive norepinephrine in the brain induces tau aggregation, neuronal death, and cognitive deficits in early tau transgenic mice
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66. Uptake of Polyelectrolyte Functionalized Upconversion Nanoparticles by Tau-Aggregated Neuron Cells
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67. DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model
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68. Thirty years of SET/TAF1β/I2PP2A: from the identification of the biological functions to its implications in cancer and Alzheimer’s disease
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69. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties
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70. Effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of Tau in the hippocampus of rats exposed to ozone
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71. A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease
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72. 9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model
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73. Acetaldehyde induces tau phosphorylation via activation of p38 MAPK/JNK and ROS production
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74. Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review
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75. A buried glutamate in the cross-β core renders β-endorphin fibrils reversible
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76. Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis of Preclinical Studies
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78. Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease
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80. NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease‐like pathology in mice by targeting protein phosphatase magnesium‐dependent 1A phosphatase
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82. Molecular Docking Studies, Bioactivity Score Prediction, Drug Likeness Analysis of GSK-3 β Inhibitors: A Target Protein Involved in Alzheimer’s Disease
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91. Cognitive erosion and its implications in Alzheimer’s disease
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93. Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis
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95. Development of tau-directed Small Molecule Modulators for Alzheimer’s Disease: a Recent Patent Review (2014–2018)
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96. Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster
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97. Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease
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99. Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking
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100. Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer’s disease
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