Tau protein kinases: Involvement in Alzheimer's disease

The protein kinase complement of the human genome

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Amyloid plaque core protein in Alzheimer disease and Down syndrome.

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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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The selectivity of protein kinase inhibitors: a further update

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The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

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Diabetic Ketoacidosis Induces Tau Hyperphosphorylation in Rat Brain

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Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice

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Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment

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Enzymes and Alzheimer's Disease: Pioneering Drug Development Strategies

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Glucose starvation induces tau phosphorylation leading to cellular stress response in fission yeast

Yılmazer, M., Şengelen, A., Aksüt, Y., Palabıyık, B., Uçar, E. Ö., & Uzuner, S. K. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04350-y · Cited by 3

Protein-protein interactions in the systems of cytochromes P450 3A4 and 3A5

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Discovery of small molecules for the treatment of Alzheimer’s disease

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Glucose Starvation Causes ptauS409 Increase in N2a Cells Through ATF3/PKAcα Signaling Pathway

Zuo, Z., Li, L., Yan, X., & Zhang, L. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03686-x · Cited by 3

Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk

Lv, J., Shen, X., Shen, X.-Y., Li, X., Jin, Z.-Y., Ouyang, X., Lu, J., Zhu, D., Wang, J., & Shen, X. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100546 · Cited by 3

Computational Modeling of Kinase Inhibitors as Anti-Alzheimer Agents

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Insights to develop tau‐directed therapeutics to protect the synaptic integrity for tauopathies

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The Insight into the Role of Protein Misfolding and Tau Oligomers in Alzheimer’s Disease

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Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP

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Endogenous tau released from human ReNCell VM cultures by neuronal activity is phosphorylated at multiple sitesPreprint

Sindi, G., Ismael, S., Uddin, R., Slepchenko, K. G., Colvin, R. A., & Lee, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.02.597022 · Cited by 3

The Association of Brain Insulin Resistance with Anesthesia/Surgery-Induced Cognitive Deterioration Is Female-Specific in 5XFAD Transgenic Mice

Zhang, J., Zhang, Y., Zhang, Y., & Yao, J. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231444 · Cited by 2

Synaptic and synchronic impairments in subcortical brain regions associated with early non-cognitive dysfunction in Alzheimer’s disease

Riffo-Lepe, N., González-Sanmiguel, J., Armijo‐Weingart, L., Saavedra, P., Hernandez, D., Ramos, G., Martín, L. S., & Aguayo, L. G. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01052 · Cited by 2

Going beyond ATP binding site as a novel inhibitor design strategy for tau protein kinases in the treatment of Alzheimer's disease: A review

Zaater, M. A., Kerdawy, A. M. E., Mahmoud, W. R., & Abou‐Seri, S. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142141 · Cited by 2

Leveraging Adaptive Evolutionary Optimization for Drug Molecular Design Involving Many Properties

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RNA-based therapeutics for Alzheimer’s disease and related tauopathies: challenges and opportunities

Rajbanshi, B., Brentari, I., Denti, M. A., Cummings, J. L., & Guruacharya, A. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100585 · Cited by 2

Neurochemical Aspects of Alzheimer Disease

Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_1 · Cited by 2

Nanomedical drug delivery for neurodegenerative disease

Kaur, N., Kumar, V., Mahender, T., Maji, I., Mahajan, S., Aalhate, M., Singh, P. K., & Sahu, S. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85544-0.00016-2 · Cited by 2

GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations

Shen, H., Zhang, T., Ji, Y., Zhang, Y., Wang, Y., Jiang, Y., Chen, X., Liang, Q., Wu, K., Lu, X., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03151-4 · Cited by 2

Medicinal chemistry-based novel herapeutics for Tauopathies in Alzheimer’s disease

Chinnathambi, S., Malik, S., Chandrashekar, M., & Kumurappan, M. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.09.001 · Cited by 2

Exploring the Anti-Alzheimer’s Disease Potential of Aspergillus terreus C23-3 Through Genomic Insights, Metabolomic Analysis, and Molecular Docking

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MosGraphFlow: a novel integrative graph AI model mining signaling targets from multi-omic data

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Immunomodulatory Methods

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Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau

Seneci, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801944-3.00001-1 · Cited by 2

Inhibitors of Tau-Phosphorylating Kinases

Fallacara, A. L., Trist, I. M. L., Schenone, S., & Botta, M. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_17 · Cited by 2

Comprehensive binary interaction mapping of τ phosphotyrosine sites with SH2 domains in the human genome: Implications for the rational design of self-inhibitory phosphopeptides to target τ hyperphosphorylation signaling in Alzheimer’s Disease

Bao, Z., Liu, J., & Fu, J. (2022) · Amino Acids · doi:10.1007/s00726-022-03171-3 · Cited by 2

Potential targeting sites in brain and brain tumors

Kaur, A., Sharma, S., Noor, A., Dang, S., & Talegaonkar, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90773-6.00017-8 · Cited by 2

Tau-Centric Therapies for Treating Alzheimer’s Disease

Quraishe, S., Cowan, C. M., & Mudher, A. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00005-3 · Cited by 1

Novel Effective Small-Molecule Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer's Disease

Opitz, A., Seitz, L.-M., Kryštof, V., Baselious, F., Holzer, M., Sippl, W., & Hilgeroth, A. (2022) · Future Medicinal Chemistry · doi:10.4155/fmc-2022-0061 · Cited by 1

Prospective role of Citicoline and nanotechnology as drug delivery approaches for Alzheimer’s disease: Review of the literature

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Tau Protein: Targets And Development Against Alzheimer’s Disease

Dubey, S., & Mahesh, A. R. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815136142123010010 · Cited by 1

Enzymatic Targets for Drug Discovery Against Alzheimer's Disease

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Traditional Herbal Medicine for Dementia Therapy

Sosa, A. E., & Hassan, Z. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-4117-5_12 · Cited by 1

Phospho-Tau Signature During Mitosis: AT8, p-T217 and p-S422 as Key Phospho-Epitopes

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Progestogens reduce tau phosphorylation via ERK 1/2 in a tau overexpression cell model

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Stabilizing microtubules increases acute cellular injury at high strain rates

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G-protein coupled receptor regulates cytoskeletal remodelling of extracellular Tau in Alzheimer’s disease

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Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review

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Chronobiology and Neurodegeneration: The Role of Melatonin in Alzheimer's Disease

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Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

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Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease

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Cellular senescence in neurodegenerative diseases: A bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications

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Peripheral biomarkers of neuroinflammation in Alzheimer’s disease and vascular dementia

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PIAS1-mediated GSK3β SUMOylation exacerbates tauopathy and cognitive deficits in Alzheimer’s disease models

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Role of cyclin-dependent kinase 5 in neurodegenerative disorders

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Pathology of different tau protein species in neurodegenerative diseases: Alzheimer’s disease, corticobasal degeneration, and progressive supranuclear palsy

Majidi, M., Rajabi, A., & Ahmadi, S. (2021) · Scientific Journal of Kurdistan University of Medical Sciences · doi:10.52547/sjku.26.3.129 · Cited by 1

PROTEÍNA TAU E AS DOENÇAS NEURODEGENERATIVAS

Rodrigues, F. D. A. A., & Oh, H. (2021) · COGNITIONIS Scientific Journal · doi:10.38087/2595.8801.90 · Cited by 1

Structural and molecular insights into tacrine-benzofuran hybrid induced inhibition of amyloid-β peptide aggregation and BACE1 activity

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Computer-Assisted Drug Design: A Toolbox for Novel Tau Kinase Inhibitors and Its Implications in Alzheimer’s Disease

Jain, A. K., Karthikeyan, C., Trivedi, P., & Konar, A. D. (2023) · Neuromethods · doi:10.1007/978-1-0716-3311-3_6 · Cited by 1

Protein–Protein Interactions in Neurodegenerative Diseases

Poluri, K. M., Gulati, K., Tripathi, D. K., & Nagar, N. (2023) · Springer eBooks · doi:10.1007/978-981-99-2423-3_3 · Cited by 2

Noise and Alzheimer's disease

Belojević, G. (2023) · Annals of Nursing · doi:10.58424/annnurs.y9e.cdx.n73 · Cited by 1

Serotonin receptors - a potential target for the treatment of Alzheimer’s disease

Eremin, D. V., Kondaurova, E. M., Rodnyy, A. Y., Molobekova, K. A., Kudlay, D. A., & Naumenko, V. S. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523120059 · Cited by 1

TEMPO

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Tau Aggregation, Conformational Selection, and Inhibition

Holden, M. R. (2018) · Digital Commons - DU (University of Denver) · Cited by 1

Proteína tau e as doenças neurodegenerativas

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Veldwerk in het onderwijs

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Karbohidrat Dalam Ekstrak Tanin Kulit Kayu Akasia (Acacia Mangium Willd)

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Functional insights from targeted imaging BACE1 : The first near-infrared fluorescent probe for Alzheimer's disease diagnosisPreprint

Bi, A., Wu, J., Huang, S., Li, Y., Zheng, F., Ding, J., Dong, J., Xiang, D.-X., & Zeng, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1642706/v2 · Cited by 1

Catestatin ameliorates tauopathy and amyloidogenesis via adrenergic inhibitionPreprint

Jati, S., Kal, S., Muñoz-Mayorga, D., Tang, K., Sahoo, D., Chen, X., & Mahata, S. K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.04.697519 · Cited by 1

Global Approaches to Understanding Protein Kinase Functions

Gorman, J. L., & Woodgett, J. R. (2015) · Wiley eBooks · doi:10.1002/9783527683031.ch1

Elucidating and Pharmacologically Targeting Secondary Injury Cascades following Neural Injury

Lucke-Wold, B. P. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6120

Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts

Stan, D. M. (2018) · University of Salford Institutional Repository (University of Salford)

Single Molecule Imaging Reveals Tau Structure And Function On The Microtubule Surface

Stern, J. L. (2018) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)

The Synthesis of 3-Vinylindolines by the Palladium-Catalyzed Intramolecular Allylic Alkylation of Cinnamyl Acetates and the Synthesis of Polyphenolic 4-Aryl-3,4-dihydrocoumarins by Domino Friedel-Crafts Reactions

Rydzik, J. (2018) · UWSpace (University of Waterloo)

Depotentiation of long-term potentiation is associated with epitope specific tau hyper/hypo phosphorylation in the hippocampus of adult rats

Delibaş, S., Tan, B., & Süer, C. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.896

Docking molecular, síntese e estudo biológico de potenciais inibidores da beta-secretase (BACE-1) e da acetilcolinesterase (AChE)

Sakata, R. P. (2018) · doi:10.47749/t/unicamp.2018.1059514

PERFLUOROOCTANESULFONIC ACID (PFOS) AS A POTENTIAL RISK FACTOR FOR LATE-ONSET ALZHEIMER’S DISEASE

Basaly, V. (2020) · doi:10.23860/thesis-basaly-veronia-2020

Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau

Savastano, A. (2020) · doi:10.53846/goediss-8370

The Association Between Single Nucleotide Polymorphisms of GSK 3b Gene and Sporadic Alzheimer's Disease in a Cohort of Southern Chinese Han Population

LiFan, J., DengJie, Z., Li, Z., & ZhangJuan, T. (2014)

Applications of nose-to-brain delivery in nanodiagnosis and nanotherapy of neurodegenerative disorders

Kulkarni, A. D., Shinde, M. N., Sonawane, G. A., Raotole, H., Pande, R., & Pardeshi, C. V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00016-3

THE ROLE OF MICROTUBULE-ASSOCIATED PROTEIN TAU IN NEURONAL EXCITABILITY AND EPILEPTOGENESIS

Cloyd, R. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.271

Ferroptosis Promotes Microtubule-Associated Protein Tau Aggregation via GSK-3β Activition and Proteasome InhibitionPreprint

Wang, S., Jiang, Y. X., Liu, Y., Liu, Q., Sun, H., Mei, M., & Liao, X. (2021) · Research Square · doi:10.21203/rs.3.rs-1062929/v1

Molecular insights into the Tau-actin interaction

Fontela, Y. C. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6842

Alzheimer’s Disease Drug Discovery in Academia: From High-Throughput Screening to In Vivo Testing

Brunden, K. R., Nzou, G., & Ballatore, C. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108975759.004

Turgut Ozal University Faculty of Medicine 6th International Student Congress

Turgut Ozal University Faculty of Medicine 6th International Student Congress (2015) · Clinical and investigative medicine · doi:10.25011/cim.v38i4.24263

Faculty Opinions recommendation of Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons.

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Alzheimer’s disease as a syndrome of overloaded amyloidic synaptic tagging in memory networksPreprint

Murphy, N. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/7gsaz

Functional insights from targeted imaging BACE1: The first near-infrared fluorescent probe for Alzheimer’s disease diagnosisPreprint

Bi, A., Wu, J., Huang, S., Li, Y., Zheng, F., Ding, J., Dong, J., Xiang, D.-X., & Zeng, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1642706/v1

Multi‐omics analysis reveals expression complexity and functional diversity of mouse kinome

Huang, X., Li, L., Zhou, S., Kong, D., Luo, J., Lu, L., Xu, H., & Wang, X. (2022) · PROTEOMICS · doi:10.1002/pmic.202200120

Synthesis and Evaluation of 1,3-Dimethylbarbituric Acid Based Enamine Derivatives as Anti-Alzheimer Agent

Shaikh, S., Uparkar, J. J., Pavale, G., & Ramana, M. M. V. (2022) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162022050193

GRK5 deficiency in the hippocampus leads to Alzheimer’s Disease-like phenotypes via the abnormal microglia alterationsPreprint

Shen, H., Zhang, T., Ji, Y., Zhang, Y., Wang, Y., Jiang, Y., Chen, X., Wu, K., Li, Y., Lu, X., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1927604/v1

Research Progress on Non-Pharmacological Interventions to Prevent Alzheimer’s Disease

翁, 湄. (2023) · Open Journal of Natural Science · doi:10.12677/ojns.2023.113042

Alzheimer’s disease beyond the amyloid accumulation

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