Cited by 474Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

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A systematic review of leukocyte telomere length and age in adults

Müezzinler, Aysel, Zaineddin, Aida Karina, Brenner, Hermann·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2013.01.003

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Abstract

Objective To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults.Methods Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients.Results Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r=-0.338, p<0.0001) and relative LTL (r=-0.295, p=0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91 BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5 BP/year).Conclusion While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.

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Additional file 4 of Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China
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Additional file 5 of Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China
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Additional file 5 of Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
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Additional file 4 of Interrelationships and determinants of aging biomarkers in cord blood
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Additional file 3 of Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China
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Additional file 2 of Interrelationships and determinants of aging biomarkers in cord blood
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Additional file 2 of Exploration of the causal effects of leukocyte telomere length and four gastrointestinal diseases: a two-sample bidirectional Mendelian randomization study
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Additional file 4 of Exploration of the causal effects of leukocyte telomere length and four gastrointestinal diseases: a two-sample bidirectional Mendelian randomization study
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Additional file 1 of Interrelationships and determinants of aging biomarkers in cord blood
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Additional file 4 of Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
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Additional file 1 of Exploration of the causal effects of leukocyte telomere length and four gastrointestinal diseases: a two-sample bidirectional Mendelian randomization study
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Additional file 3 of Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
Clarity, C., Trowbridge, J., Gerona, R. R. L., Ona, K., McMaster, M., Bessonneau, V., Rudel, R. A., Buren, H., & Morello-Frosch, R. A. (2021) · Figshare · doi:10.6084/m9.figshare.16530200
Additional file 2 of Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
Clarity, C., Trowbridge, J., Gerona, R., Ona, K., McMaster, M., Bessonneau, V., Rudel, R. A., Buren, H., & Morello-Frosch, R. A. (2021) · Figshare · doi:10.6084/m9.figshare.16530197
Additional file 2 of Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China
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Additional file 5 of Interrelationships and determinants of aging biomarkers in cord blood
Reimann, B., Martens, D. S., Wang, C., Ghantous, A., Herceg, Z., Plusquin, M., & Nawrot, T. S. (2022) · Figshare · doi:10.6084/m9.figshare.20462323
Additional file 1 of Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China
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Additional file 1 of Association of pregnancy complications and postpartum maternal leukocyte telomeres in two diverse cohorts: a nested case-control study
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Authors: Müezzinler, A., Zaineddin, A. K., & Brenner, H.
Affiliations: German Cancer Research Center (DE)
Corresponding author: Müezzinler, Aysel
ORCID: Brenner, Hermann
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-03
Volume: 12
Issue: 2
Pages: 509-519
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2013.01.003
OpenAlex: W2000059391
Cited by: 474
References: 165
Citations by year: 2026: 14 · 2025: 19 · 2024: 34 · 2023: 31 · 2022: 49 · 2021: 41 · 2020: 46 · 2019: 60 · 2018: 36 · 2017: 49 · 2016: 38 · 2015: 28 · 2014: 23 · 2013: 5
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Klaus Tschira Stiftung
Hellenic Health Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: leukocyte telomere length, aging, telomere shortening, age-related telomere shortening, adults, sex differences
MeSH terms: Age Factors, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Humans, Leukocytes, Longitudinal Studies, Middle Aged, Linear Models, Telomere Homeostasis, Telomere Shortening

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A systematic review of leukocyte telomere length and age in adults

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