The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Exercise benefits on Alzheimer’s disease: State-of-the-science
Abstract
Although there is no unanimity, growing evidence supports the value of regular physical exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients. Together with an introductory summary on epidemiological evidence, the aim of this review is to summarize the current knowledge on the potential biological mechanisms underlying exercise benefits in this condition. Regular physical exercise has proven to be beneficial for traditional cardiovascular risk factors (e.g., reduced vascular flow, diabetes) involved in the pathogenesis of Alzheimer's disease. Exercise also promotes neurogenesis via increases in exercise-induced metabolic factors (e.g., ketone bodies, lactate) and muscle-derived myokines (cathepsin-B, irisin), which in turn stimulate the production of neurotrophins such as brain-derived neurotrophic factor. Finally, regular exercise exerts anti-inflammatory effects and improves the brain redox status, thereby ameliorating the pathophysiological hallmarks of Alzheimer's disease (e.g., amyloid-β deposition). In summary, physical exercise might provide numerous benefits through different pathways that might, in turn, help prevent risk and progression of Alzheimer's disease. More evidence is needed, however, based on human studies.
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“These beneficial changes underscore the importance of exercise in preventing and slowing the progression of ageing as well as neurodegenerative diseases.504–508”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [506]
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“Moreover, accumulating evidence suggests that physical activity, as shown in preclinical, observational and interventional studies in humans, can prevent or delay the onset of neurodegenerative conditions138.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [138]
Citations
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López-Ortiz, S., Valenzuela, P. L., Seisdedos, M. M., Morales, J. S., Vega, T., Castillo-García, A., Nisticò, R., Mercuri, N. B., Lista, S., Lucia, A., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101479 · Cited by 152
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Metadata
- Authors
- Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A.
- Affiliations
- Universidad de Alcalá (ES)
- Universidad Europea de Madrid (ES)
- Sorbonne Université (FR)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 62
- Pages
- 101108
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W3036541872
- Cited by
- 337
- References
- 215
- Citations by year
- 2026: 41 · 2025: 64 · 2024: 67 · 2023: 68 · 2022: 51 · 2021: 37 · 2020: 9
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
- Funders
- Ministerio de Educación, Cultura y Deporte (FPU14/03435)
- Fondation pour la Recherche sur Alzheimer
- Ministerio de Economía y Competitividad
- Association Sorbonne Université
- Eisai
- Universidad de Alcalá (FPI2016)
- European Regional Development Fund (PI18/00139)
- AXA Research Fund
- Sorbonne Université
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- Alzheimer's disease, physical activity, cognitive decline, neurogenesis, myokines, irisin, cathepsin B, brain-derived neurotrophic factor, neuroinflammation, oxidative stress, amyloid-beta, ketone bodies, lactate, cardiovascular risk factors, diabetes mellitus
- MeSH terms
- Alzheimer Disease, Brain, Exercise Therapy, Humans, Exercise, Neurogenesis
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