Cited by 337Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPhysical Activity and Health

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Exercise benefits on Alzheimer’s disease: State-of-the-science

Valenzuela, Pedro L., Castillo-García, Adrián, Morales, Javier S., de la Villa, Pedro, Hampel, Harald, Emanuele, Enzo, Lista, Simone, Lucia, Alejandro·2020·Ageing Research Reviews

DOI 10.1016/j.arr.2020.101108

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Abstract

Although there is no unanimity, growing evidence supports the value of regular physical exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients. Together with an introductory summary on epidemiological evidence, the aim of this review is to summarize the current knowledge on the potential biological mechanisms underlying exercise benefits in this condition. Regular physical exercise has proven to be beneficial for traditional cardiovascular risk factors (e.g., reduced vascular flow, diabetes) involved in the pathogenesis of Alzheimer's disease. Exercise also promotes neurogenesis via increases in exercise-induced metabolic factors (e.g., ketone bodies, lactate) and muscle-derived myokines (cathepsin-B, irisin), which in turn stimulate the production of neurotrophins such as brain-derived neurotrophic factor. Finally, regular exercise exerts anti-inflammatory effects and improves the brain redox status, thereby ameliorating the pathophysiological hallmarks of Alzheimer's disease (e.g., amyloid-β deposition). In summary, physical exercise might provide numerous benefits through different pathways that might, in turn, help prevent risk and progression of Alzheimer's disease. More evidence is needed, however, based on human studies.

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Authors: Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A.
Affiliations: Universidad de Alcalá (ES)
Universidad Europea de Madrid (ES)
Sorbonne Université (FR)
Centre National de la Recherche Scientifique (FR)
ORCID: Valenzuela, Pedro L.
Morales, Javier S.
Hampel, Harald
Emanuele, Enzo
Lista, Simone
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2020-09
Volume: 62
Pages: 101108
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2020.101108
OpenAlex: W3036541872
Cited by: 337
References: 215
Citations by year: 2026: 41 · 2025: 64 · 2024: 67 · 2023: 68 · 2022: 51 · 2021: 37 · 2020: 9
FWCI: 6.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
Funders: Ministerio de Educación, Cultura y Deporte (FPU14/03435)
Fondation pour la Recherche sur Alzheimer
Ministerio de Economía y Competitividad
Association Sorbonne Université
Eisai
Universidad de Alcalá (FPI2016)
European Regional Development Fund (PI18/00139)
AXA Research Fund
Sorbonne Université
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: Alzheimer's disease, physical activity, cognitive decline, neurogenesis, myokines, irisin, cathepsin B, brain-derived neurotrophic factor, neuroinflammation, oxidative stress, amyloid-beta, ketone bodies, lactate, cardiovascular risk factors, diabetes mellitus
MeSH terms: Alzheimer Disease, Brain, Exercise Therapy, Humans, Exercise, Neurogenesis

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